A Phase II Randomized Trial of Amphotericin B Alone or Combined with Fluconazole in the Treatment of HIV-Associated Cryptococcal Meningitis

Background. Cryptococcosis is a life-threatening infection among patients with human immunodeficientcy virus (HIV) infection. Therapeutic options for the treatment of central nervous system cryptococcosis are limited, especially in resource-limited settings. Methods. We conducted a randomized, open-...

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Veröffentlicht in:	Clinical infectious diseases 2009-06, Vol.48 (12), p.1775-1783
Hauptverfasser:	Pappas, Peter G., Chetchotisakd, Ploenchan, Larsen, Robert A., Manosuthi, Weerawat, Morris, Michele I., Anekthananon, Thomansak, Sungkanuparph, Somnuek, Supparatpinyo, Khauncahi, Nolen, Tracy L., Zimmer, Louise O., Kendrick, Amy S., Johnson, Phillip, Sobel, Jack D., Filler, Scott G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amphotericin B - administration & dosage Amphotericin B - adverse effects Amphotericin B - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - administration & dosage Antifungal Agents - adverse effects Antifungal Agents - therapeutic use Antiretroviral drugs Biological and medical sciences Cerebrospinal Fluid - microbiology Clinical trials Comparative analysis Female Fluconazole - administration & dosage Fluconazole - adverse effects Fluconazole - therapeutic use HIV HIV Infections - complications Human immunodeficiency virus Human mycoses Human viral diseases Humans Infectious diseases Male Medical sciences Medical treatment Meningitis Meningitis, Cryptococcal - drug therapy Middle Aged Miscellaneous mycoses Mycoses Nervous system Pharmacology. Drug treatments Survival Analysis Thailand Treatment Outcome United States Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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