Off-flavor of red sea bream Pagrus major reared in recirculating aquaculture systems with low salinity is caused by 2-methylisoborneol
We detected an earthy/musty off-flavor in the flesh of red sea bream Pagrus major cultured under low saline water conditions using two types of recirculating aquaculture systems (RAS). The compound causing the off-flavor was identified, and we investigated how the ultraviolet (UV) equipment of the R...
Gespeichert in:
| Veröffentlicht in: | Fisheries science 2019-05, Vol.85 (3), p.553-560 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 560 |
|---|---|
| container_issue | 3 |
| container_start_page | 553 |
| container_title | Fisheries science |
| container_volume | 85 |
| creator | Kawaguchi, Osamu Tanaka, Mao Yoshii, Minami Iwamoto, Yuji Midooka, Anise Toutani, Fukutarou Nagao, Norio Matsumoto, Takuya Mabuchi, Ryota Tanimoto, Shota |
| description | We detected an earthy/musty off-flavor in the flesh of red sea bream
Pagrus major
cultured under low saline water conditions using two types of recirculating aquaculture systems (RAS). The compound causing the off-flavor was identified, and we investigated how the ultraviolet (UV) equipment of the RAS affected the concentrations of off-flavor compounds in fish flesh and rearing water. Odor intensity was lower in the muscle of fish from RAS equipped with a UV device (UV+) compared to RAS with no UV device (UV−). In total, 107 volatiles were identified in the muscles of fish from each RAS and sea cage (control) by gas chromatography–mass spectrometry. The volatile compounds previously reported to be responsible for the off-flavor were not detected. The odorous compound that caused the off-flavor in red sea bream flesh from both of the RAS was identified by gas chromatography–olfactometry as 2-methylisoborneol (2-MIB). The concentrations of 2-MIB in the fish flesh and rearing water were lower in UV+ compared to UV−. In conclusion, the problem of an off-flavor in marine fish reared in RAS-type temporary rearing tanks with diluted seawater will likely increase as more marine fish species are reared under these conditions. |
| doi_str_mv | 10.1007/s12562-019-01307-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2199612570</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2199612570</sourcerecordid><originalsourceid>FETCH-LOGICAL-c319t-47ad3cdd17ecae01caf49c3f8d8e879087f5cb3081fe5df202849c0b876c41773</originalsourceid><addsrcrecordid>eNp9kMtOxCAUhonRxPHyAq5IXFcPtFNgaYy3xEQXuiaUwsikLSOn1fQFfG4Zx8SdC3Lg_BeSj5AzBhcMQFwi48uaF8BUPiWIgu2RBauqquAK6n2yAJUlxWt5SI4Q1wBQL0EuyNeT94XvzEdMNHqaXEvRGdokZ3r6bFZpQtqbdVbzZquGId9sSHbqzBiGFTXvk8mPcUqO4oyj65F-hvGNdvGTounCEMaZBqTWTJgLmpnyonfj29wFjE1Mg4vdCTnwpkN3-juPyevtzcv1ffH4dPdwffVY2JKpsaiEaUvbtkw4axwwa3ylbOllK50UCqTwS9uUIJl3y9Zz4DLr0EhR24oJUR6T813vJsX3yeGo13FKQ_5Sc6ZUnTEKyC6-c9kUEZPzepNCb9KsGegtb73jrTNv_cNbsxwqdyHM5mHl0l_1P6lvY12FyQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2199612570</pqid></control><display><type>article</type><title>Off-flavor of red sea bream Pagrus major reared in recirculating aquaculture systems with low salinity is caused by 2-methylisoborneol</title><source>SpringerLink Journals</source><creator>Kawaguchi, Osamu ; Tanaka, Mao ; Yoshii, Minami ; Iwamoto, Yuji ; Midooka, Anise ; Toutani, Fukutarou ; Nagao, Norio ; Matsumoto, Takuya ; Mabuchi, Ryota ; Tanimoto, Shota</creator><creatorcontrib>Kawaguchi, Osamu ; Tanaka, Mao ; Yoshii, Minami ; Iwamoto, Yuji ; Midooka, Anise ; Toutani, Fukutarou ; Nagao, Norio ; Matsumoto, Takuya ; Mabuchi, Ryota ; Tanimoto, Shota</creatorcontrib><description>We detected an earthy/musty off-flavor in the flesh of red sea bream
Pagrus major
cultured under low saline water conditions using two types of recirculating aquaculture systems (RAS). The compound causing the off-flavor was identified, and we investigated how the ultraviolet (UV) equipment of the RAS affected the concentrations of off-flavor compounds in fish flesh and rearing water. Odor intensity was lower in the muscle of fish from RAS equipped with a UV device (UV+) compared to RAS with no UV device (UV−). In total, 107 volatiles were identified in the muscles of fish from each RAS and sea cage (control) by gas chromatography–mass spectrometry. The volatile compounds previously reported to be responsible for the off-flavor were not detected. The odorous compound that caused the off-flavor in red sea bream flesh from both of the RAS was identified by gas chromatography–olfactometry as 2-methylisoborneol (2-MIB). The concentrations of 2-MIB in the fish flesh and rearing water were lower in UV+ compared to UV−. In conclusion, the problem of an off-flavor in marine fish reared in RAS-type temporary rearing tanks with diluted seawater will likely increase as more marine fish species are reared under these conditions.</description><identifier>ISSN: 0919-9268</identifier><identifier>EISSN: 1444-2906</identifier><identifier>DOI: 10.1007/s12562-019-01307-1</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>2-Methylisoborneol ; Aquaculture ; Aquaculture systems ; Aquaculture techniques ; Aroma compounds ; Biomedical and Life Sciences ; Bream ; Chemical analysis ; Chromatography ; Fish ; Fish & Wildlife Biology & Management ; Flavor compounds ; Flavors ; Flavour ; Food Science ; Freshwater & Marine Ecology ; Gas chromatography ; Identification ; Individual rearing ; Life Sciences ; Marine fish ; Marine fishes ; Mass spectrometry ; Mass spectroscopy ; Muscles ; Odor intensity ; Odour ; Off flavor ; Olfactometers ; Original Article ; Pagrus major ; Recirculating aquaculture systems ; Saline water ; Salinity ; Seawater ; Tanks ; Ultraviolet radiation ; Volatile compounds ; Volatiles ; Water analysis</subject><ispartof>Fisheries science, 2019-05, Vol.85 (3), p.553-560</ispartof><rights>Japanese Society of Fisheries Science 2019</rights><rights>Fisheries Science is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-47ad3cdd17ecae01caf49c3f8d8e879087f5cb3081fe5df202849c0b876c41773</citedby><cites>FETCH-LOGICAL-c319t-47ad3cdd17ecae01caf49c3f8d8e879087f5cb3081fe5df202849c0b876c41773</cites><orcidid>0000-0002-0963-390X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12562-019-01307-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12562-019-01307-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Kawaguchi, Osamu</creatorcontrib><creatorcontrib>Tanaka, Mao</creatorcontrib><creatorcontrib>Yoshii, Minami</creatorcontrib><creatorcontrib>Iwamoto, Yuji</creatorcontrib><creatorcontrib>Midooka, Anise</creatorcontrib><creatorcontrib>Toutani, Fukutarou</creatorcontrib><creatorcontrib>Nagao, Norio</creatorcontrib><creatorcontrib>Matsumoto, Takuya</creatorcontrib><creatorcontrib>Mabuchi, Ryota</creatorcontrib><creatorcontrib>Tanimoto, Shota</creatorcontrib><title>Off-flavor of red sea bream Pagrus major reared in recirculating aquaculture systems with low salinity is caused by 2-methylisoborneol</title><title>Fisheries science</title><addtitle>Fish Sci</addtitle><description>We detected an earthy/musty off-flavor in the flesh of red sea bream
Pagrus major
cultured under low saline water conditions using two types of recirculating aquaculture systems (RAS). The compound causing the off-flavor was identified, and we investigated how the ultraviolet (UV) equipment of the RAS affected the concentrations of off-flavor compounds in fish flesh and rearing water. Odor intensity was lower in the muscle of fish from RAS equipped with a UV device (UV+) compared to RAS with no UV device (UV−). In total, 107 volatiles were identified in the muscles of fish from each RAS and sea cage (control) by gas chromatography–mass spectrometry. The volatile compounds previously reported to be responsible for the off-flavor were not detected. The odorous compound that caused the off-flavor in red sea bream flesh from both of the RAS was identified by gas chromatography–olfactometry as 2-methylisoborneol (2-MIB). The concentrations of 2-MIB in the fish flesh and rearing water were lower in UV+ compared to UV−. In conclusion, the problem of an off-flavor in marine fish reared in RAS-type temporary rearing tanks with diluted seawater will likely increase as more marine fish species are reared under these conditions.</description><subject>2-Methylisoborneol</subject><subject>Aquaculture</subject><subject>Aquaculture systems</subject><subject>Aquaculture techniques</subject><subject>Aroma compounds</subject><subject>Biomedical and Life Sciences</subject><subject>Bream</subject><subject>Chemical analysis</subject><subject>Chromatography</subject><subject>Fish</subject><subject>Fish & Wildlife Biology & Management</subject><subject>Flavor compounds</subject><subject>Flavors</subject><subject>Flavour</subject><subject>Food Science</subject><subject>Freshwater & Marine Ecology</subject><subject>Gas chromatography</subject><subject>Identification</subject><subject>Individual rearing</subject><subject>Life Sciences</subject><subject>Marine fish</subject><subject>Marine fishes</subject><subject>Mass spectrometry</subject><subject>Mass spectroscopy</subject><subject>Muscles</subject><subject>Odor intensity</subject><subject>Odour</subject><subject>Off flavor</subject><subject>Olfactometers</subject><subject>Original Article</subject><subject>Pagrus major</subject><subject>Recirculating aquaculture systems</subject><subject>Saline water</subject><subject>Salinity</subject><subject>Seawater</subject><subject>Tanks</subject><subject>Ultraviolet radiation</subject><subject>Volatile compounds</subject><subject>Volatiles</subject><subject>Water analysis</subject><issn>0919-9268</issn><issn>1444-2906</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kMtOxCAUhonRxPHyAq5IXFcPtFNgaYy3xEQXuiaUwsikLSOn1fQFfG4Zx8SdC3Lg_BeSj5AzBhcMQFwi48uaF8BUPiWIgu2RBauqquAK6n2yAJUlxWt5SI4Q1wBQL0EuyNeT94XvzEdMNHqaXEvRGdokZ3r6bFZpQtqbdVbzZquGId9sSHbqzBiGFTXvk8mPcUqO4oyj65F-hvGNdvGTounCEMaZBqTWTJgLmpnyonfj29wFjE1Mg4vdCTnwpkN3-juPyevtzcv1ffH4dPdwffVY2JKpsaiEaUvbtkw4axwwa3ylbOllK50UCqTwS9uUIJl3y9Zz4DLr0EhR24oJUR6T813vJsX3yeGo13FKQ_5Sc6ZUnTEKyC6-c9kUEZPzepNCb9KsGegtb73jrTNv_cNbsxwqdyHM5mHl0l_1P6lvY12FyQ</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Kawaguchi, Osamu</creator><creator>Tanaka, Mao</creator><creator>Yoshii, Minami</creator><creator>Iwamoto, Yuji</creator><creator>Midooka, Anise</creator><creator>Toutani, Fukutarou</creator><creator>Nagao, Norio</creator><creator>Matsumoto, Takuya</creator><creator>Mabuchi, Ryota</creator><creator>Tanimoto, Shota</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TN</scope><scope>7U7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7XB</scope><scope>87Z</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8FL</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FRNLG</scope><scope>F~G</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H95</scope><scope>H98</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>L.-</scope><scope>L.G</scope><scope>LK8</scope><scope>M0C</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PCBAR</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><orcidid>https://orcid.org/0000-0002-0963-390X</orcidid></search><sort><creationdate>20190501</creationdate><title>Off-flavor of red sea bream Pagrus major reared in recirculating aquaculture systems with low salinity is caused by 2-methylisoborneol</title><author>Kawaguchi, Osamu ; Tanaka, Mao ; Yoshii, Minami ; Iwamoto, Yuji ; Midooka, Anise ; Toutani, Fukutarou ; Nagao, Norio ; Matsumoto, Takuya ; Mabuchi, Ryota ; Tanimoto, Shota</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-47ad3cdd17ecae01caf49c3f8d8e879087f5cb3081fe5df202849c0b876c41773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>2-Methylisoborneol</topic><topic>Aquaculture</topic><topic>Aquaculture systems</topic><topic>Aquaculture techniques</topic><topic>Aroma compounds</topic><topic>Biomedical and Life Sciences</topic><topic>Bream</topic><topic>Chemical analysis</topic><topic>Chromatography</topic><topic>Fish</topic><topic>Fish & Wildlife Biology & Management</topic><topic>Flavor compounds</topic><topic>Flavors</topic><topic>Flavour</topic><topic>Food Science</topic><topic>Freshwater & Marine Ecology</topic><topic>Gas chromatography</topic><topic>Identification</topic><topic>Individual rearing</topic><topic>Life Sciences</topic><topic>Marine fish</topic><topic>Marine fishes</topic><topic>Mass spectrometry</topic><topic>Mass spectroscopy</topic><topic>Muscles</topic><topic>Odor intensity</topic><topic>Odour</topic><topic>Off flavor</topic><topic>Olfactometers</topic><topic>Original Article</topic><topic>Pagrus major</topic><topic>Recirculating aquaculture systems</topic><topic>Saline water</topic><topic>Salinity</topic><topic>Seawater</topic><topic>Tanks</topic><topic>Ultraviolet radiation</topic><topic>Volatile compounds</topic><topic>Volatiles</topic><topic>Water analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawaguchi, Osamu</creatorcontrib><creatorcontrib>Tanaka, Mao</creatorcontrib><creatorcontrib>Yoshii, Minami</creatorcontrib><creatorcontrib>Iwamoto, Yuji</creatorcontrib><creatorcontrib>Midooka, Anise</creatorcontrib><creatorcontrib>Toutani, Fukutarou</creatorcontrib><creatorcontrib>Nagao, Norio</creatorcontrib><creatorcontrib>Matsumoto, Takuya</creatorcontrib><creatorcontrib>Mabuchi, Ryota</creatorcontrib><creatorcontrib>Tanimoto, Shota</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Access via ABI/INFORM (ProQuest)</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Global (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Business Premium Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Business Premium Collection (Alumni)</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Aquaculture Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ABI/INFORM Professional Advanced</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>ABI/INFORM Global</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Business</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Fisheries science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawaguchi, Osamu</au><au>Tanaka, Mao</au><au>Yoshii, Minami</au><au>Iwamoto, Yuji</au><au>Midooka, Anise</au><au>Toutani, Fukutarou</au><au>Nagao, Norio</au><au>Matsumoto, Takuya</au><au>Mabuchi, Ryota</au><au>Tanimoto, Shota</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Off-flavor of red sea bream Pagrus major reared in recirculating aquaculture systems with low salinity is caused by 2-methylisoborneol</atitle><jtitle>Fisheries science</jtitle><stitle>Fish Sci</stitle><date>2019-05-01</date><risdate>2019</risdate><volume>85</volume><issue>3</issue><spage>553</spage><epage>560</epage><pages>553-560</pages><issn>0919-9268</issn><eissn>1444-2906</eissn><abstract>We detected an earthy/musty off-flavor in the flesh of red sea bream
Pagrus major
cultured under low saline water conditions using two types of recirculating aquaculture systems (RAS). The compound causing the off-flavor was identified, and we investigated how the ultraviolet (UV) equipment of the RAS affected the concentrations of off-flavor compounds in fish flesh and rearing water. Odor intensity was lower in the muscle of fish from RAS equipped with a UV device (UV+) compared to RAS with no UV device (UV−). In total, 107 volatiles were identified in the muscles of fish from each RAS and sea cage (control) by gas chromatography–mass spectrometry. The volatile compounds previously reported to be responsible for the off-flavor were not detected. The odorous compound that caused the off-flavor in red sea bream flesh from both of the RAS was identified by gas chromatography–olfactometry as 2-methylisoborneol (2-MIB). The concentrations of 2-MIB in the fish flesh and rearing water were lower in UV+ compared to UV−. In conclusion, the problem of an off-flavor in marine fish reared in RAS-type temporary rearing tanks with diluted seawater will likely increase as more marine fish species are reared under these conditions.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><doi>10.1007/s12562-019-01307-1</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-0963-390X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0919-9268 |
| ispartof | Fisheries science, 2019-05, Vol.85 (3), p.553-560 |
| issn | 0919-9268 1444-2906 |
| language | eng |
| recordid | cdi_proquest_journals_2199612570 |
| source | SpringerLink Journals |
| subjects | 2-Methylisoborneol Aquaculture Aquaculture systems Aquaculture techniques Aroma compounds Biomedical and Life Sciences Bream Chemical analysis Chromatography Fish Fish & Wildlife Biology & Management Flavor compounds Flavors Flavour Food Science Freshwater & Marine Ecology Gas chromatography Identification Individual rearing Life Sciences Marine fish Marine fishes Mass spectrometry Mass spectroscopy Muscles Odor intensity Odour Off flavor Olfactometers Original Article Pagrus major Recirculating aquaculture systems Saline water Salinity Seawater Tanks Ultraviolet radiation Volatile compounds Volatiles Water analysis |
| title | Off-flavor of red sea bream Pagrus major reared in recirculating aquaculture systems with low salinity is caused by 2-methylisoborneol |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T09%3A47%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Off-flavor%20of%20red%20sea%20bream%20Pagrus%20major%20reared%20in%20recirculating%20aquaculture%20systems%20with%20low%20salinity%20is%20caused%20by%202-methylisoborneol&rft.jtitle=Fisheries%20science&rft.au=Kawaguchi,%20Osamu&rft.date=2019-05-01&rft.volume=85&rft.issue=3&rft.spage=553&rft.epage=560&rft.pages=553-560&rft.issn=0919-9268&rft.eissn=1444-2906&rft_id=info:doi/10.1007/s12562-019-01307-1&rft_dat=%3Cproquest_cross%3E2199612570%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2199612570&rft_id=info:pmid/&rfr_iscdi=true |