Sphincter-Preserving Operations Following Preoperative Chemoradiation: An Alternative to Abdominoperineal Resection for Lower Rectal Cancer?
Background Sphincter-preserving operations (SPO) for lower rectal cancer are on the rise. In the study reported here, we compared the oncologic outcomes of patients who underwent sphincter-preserving operations following preoperative chemoradiation for lower rectal cancer with the outcome for patien...
Gespeichert in:
| Veröffentlicht in: | World journal of surgery 2008-06, Vol.32 (6), p.1116-1123 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1123 |
|---|---|
| container_issue | 6 |
| container_start_page | 1116 |
| container_title | World journal of surgery |
| container_volume | 32 |
| creator | Huh, Jung Wook Jung, Eun Joo Park, Yoon Ah Lee, Kang Young Sohn, Seung-Kook |
| description | Background
Sphincter-preserving operations (SPO) for lower rectal cancer are on the rise. In the study reported here, we compared the oncologic outcomes of patients who underwent sphincter-preserving operations following preoperative chemoradiation for lower rectal cancer with the outcome for patients who underwent abdominoperineal resection (APR).
Methods
This prospective study included 87 patients who underwent proctectomy with curative intent for locally advanced rectal cancer that was located less than 6 cm from the anal verge. Forty-four patients had APR with no preoperative treatment. Forty-three patients underwent concurrent chemoradiation therapy (CCRT) consisting of preoperative 5-fluorouracil–based chemotherapy and pelvic radiation (4500–5040 cGy); this was followed 6 weeks later by surgery (SPO/CCRT). The oncologic outcomes between the two groups were compared, and factors affecting survival were evaluated.
Results
The median follow-up period was 56.2 months. The overall postoperative complication rates did not significantly differ between SPO/CCRT and APR (32.6% versus 34.2%;
p
= 0.879). Also, there were no significant differences in the overall recurrence rate (20.9% versus 20.5%;
p
= 0.956) and 5-year overall survival rate (70.8% versus 62.9%;
p
= 0.189) between the two groups. By multivariate analysis, only the pathologic N stage was significantly associated with overall survival (
p
|
| doi_str_mv | 10.1007/s00268-008-9520-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_219948430</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1484772521</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4498-5f5c5b1f35c7be2f6318dc2278e09d3b6a6df6cde437b4e382e0e65bd44a078a3</originalsourceid><addsrcrecordid>eNqFkN2O0zAQhS0EYkvhAbhBFhKXgfFPHIcbVCrKjyotYkFcWo4z2fUqjbt2utW-Aw-NQyr2CnFla-Y7Z2YOIc8ZvGYA1ZsEwJUuAHRRlxwK9oAsmBS84IKLh2QBQsn8Z-KMPEnpGoBVCtRjcsa0EKB4tSC_LvZXfnAjxuJrxITx1g-X9HyP0Y4-DIluQt-H41TM_TDXb5Gur3AXom39H-wtXQ101WeXYW6Pga6aNuz8MEn8gLan37K9m2jahUi34Ygx19yYW2s7OIzvnpJHne0TPju9S_Jj8-H7-lOxPf_4eb3aFk7KWhdlV7qyYZ0oXdUg75RgunWcVxqhbkWjrGo75VqUomokCs0RUJVNK6WFSluxJC9n330MNwdMo7kOh7x6nwxndS21FJAhNkMuhpQidmYf_c7GO8PATPGbOX6T4zdT_IZlzYuT8aHZYXuvOOWdgVcnwCZn-y7mw336y3GQjCk2Da9n7uh7vPv_ZPPzy8X7DYg6T1oSPmtTlg2XGO-v-_fmvwFz5LBm</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>219948430</pqid></control><display><type>article</type><title>Sphincter-Preserving Operations Following Preoperative Chemoradiation: An Alternative to Abdominoperineal Resection for Lower Rectal Cancer?</title><source>MEDLINE</source><source>Wiley Online Library Journals</source><source>SpringerLink Journals - AutoHoldings</source><creator>Huh, Jung Wook ; Jung, Eun Joo ; Park, Yoon Ah ; Lee, Kang Young ; Sohn, Seung-Kook</creator><creatorcontrib>Huh, Jung Wook ; Jung, Eun Joo ; Park, Yoon Ah ; Lee, Kang Young ; Sohn, Seung-Kook</creatorcontrib><description>Background
Sphincter-preserving operations (SPO) for lower rectal cancer are on the rise. In the study reported here, we compared the oncologic outcomes of patients who underwent sphincter-preserving operations following preoperative chemoradiation for lower rectal cancer with the outcome for patients who underwent abdominoperineal resection (APR).
Methods
This prospective study included 87 patients who underwent proctectomy with curative intent for locally advanced rectal cancer that was located less than 6 cm from the anal verge. Forty-four patients had APR with no preoperative treatment. Forty-three patients underwent concurrent chemoradiation therapy (CCRT) consisting of preoperative 5-fluorouracil–based chemotherapy and pelvic radiation (4500–5040 cGy); this was followed 6 weeks later by surgery (SPO/CCRT). The oncologic outcomes between the two groups were compared, and factors affecting survival were evaluated.
Results
The median follow-up period was 56.2 months. The overall postoperative complication rates did not significantly differ between SPO/CCRT and APR (32.6% versus 34.2%;
p
= 0.879). Also, there were no significant differences in the overall recurrence rate (20.9% versus 20.5%;
p
= 0.956) and 5-year overall survival rate (70.8% versus 62.9%;
p
= 0.189) between the two groups. By multivariate analysis, only the pathologic N stage was significantly associated with overall survival (
p
< 0.001).
Conclusions
Sphincter-preserving operation with CCRT could be another option for the treatment of locally advanced lower rectal cancer in patients who are clinically considered for APR, with no deterioration of oncologic outcomes. For patients undergoing curative resection for lower rectal cancer, the pathologic N stage can provide valuable prognostic information about survival.</description><identifier>ISSN: 0364-2313</identifier><identifier>EISSN: 1432-2323</identifier><identifier>DOI: 10.1007/s00268-008-9520-1</identifier><identifier>PMID: 18330627</identifier><identifier>CODEN: WJSUDI</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Abdominal Surgery ; Adenocarcinoma - drug therapy ; Adenocarcinoma - radiotherapy ; Adenocarcinoma - surgery ; Adult ; Advanced Rectal Cancer ; Aged ; Aged, 80 and over ; Anal Canal - surgery ; Anterior Resection ; Antineoplastic Agents - administration & dosage ; Biological and medical sciences ; Cardiac Surgery ; Colectomy - methods ; Female ; Fluorouracil - administration & dosage ; Gastroenterology. Liver. Pancreas. Abdomen ; General aspects ; General Surgery ; Humans ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoadjuvant Therapy ; Oncologic Outcome ; Prospective Studies ; Rectal Cancer ; Rectal Neoplasms - drug therapy ; Rectal Neoplasms - radiotherapy ; Rectal Neoplasms - surgery ; Rectum - surgery ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Surgery ; Survival Analysis ; Thoracic Surgery ; Total Mesorectal Excision ; Treatment Outcome ; Tumors ; Vascular Surgery</subject><ispartof>World journal of surgery, 2008-06, Vol.32 (6), p.1116-1123</ispartof><rights>Société Internationale de Chirurgie 2008</rights><rights>2008 The Author(s) under exclusive licence to Société Internationale de Chirurgie</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4498-5f5c5b1f35c7be2f6318dc2278e09d3b6a6df6cde437b4e382e0e65bd44a078a3</citedby><cites>FETCH-LOGICAL-c4498-5f5c5b1f35c7be2f6318dc2278e09d3b6a6df6cde437b4e382e0e65bd44a078a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00268-008-9520-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00268-008-9520-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,41488,42557,45574,45575,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20411610$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18330627$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huh, Jung Wook</creatorcontrib><creatorcontrib>Jung, Eun Joo</creatorcontrib><creatorcontrib>Park, Yoon Ah</creatorcontrib><creatorcontrib>Lee, Kang Young</creatorcontrib><creatorcontrib>Sohn, Seung-Kook</creatorcontrib><title>Sphincter-Preserving Operations Following Preoperative Chemoradiation: An Alternative to Abdominoperineal Resection for Lower Rectal Cancer?</title><title>World journal of surgery</title><addtitle>World J Surg</addtitle><addtitle>World J Surg</addtitle><description>Background
Sphincter-preserving operations (SPO) for lower rectal cancer are on the rise. In the study reported here, we compared the oncologic outcomes of patients who underwent sphincter-preserving operations following preoperative chemoradiation for lower rectal cancer with the outcome for patients who underwent abdominoperineal resection (APR).
Methods
This prospective study included 87 patients who underwent proctectomy with curative intent for locally advanced rectal cancer that was located less than 6 cm from the anal verge. Forty-four patients had APR with no preoperative treatment. Forty-three patients underwent concurrent chemoradiation therapy (CCRT) consisting of preoperative 5-fluorouracil–based chemotherapy and pelvic radiation (4500–5040 cGy); this was followed 6 weeks later by surgery (SPO/CCRT). The oncologic outcomes between the two groups were compared, and factors affecting survival were evaluated.
Results
The median follow-up period was 56.2 months. The overall postoperative complication rates did not significantly differ between SPO/CCRT and APR (32.6% versus 34.2%;
p
= 0.879). Also, there were no significant differences in the overall recurrence rate (20.9% versus 20.5%;
p
= 0.956) and 5-year overall survival rate (70.8% versus 62.9%;
p
= 0.189) between the two groups. By multivariate analysis, only the pathologic N stage was significantly associated with overall survival (
p
< 0.001).
Conclusions
Sphincter-preserving operation with CCRT could be another option for the treatment of locally advanced lower rectal cancer in patients who are clinically considered for APR, with no deterioration of oncologic outcomes. For patients undergoing curative resection for lower rectal cancer, the pathologic N stage can provide valuable prognostic information about survival.</description><subject>Abdominal Surgery</subject><subject>Adenocarcinoma - drug therapy</subject><subject>Adenocarcinoma - radiotherapy</subject><subject>Adenocarcinoma - surgery</subject><subject>Adult</subject><subject>Advanced Rectal Cancer</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anal Canal - surgery</subject><subject>Anterior Resection</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Cardiac Surgery</subject><subject>Colectomy - methods</subject><subject>Female</subject><subject>Fluorouracil - administration & dosage</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>General aspects</subject><subject>General Surgery</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoadjuvant Therapy</subject><subject>Oncologic Outcome</subject><subject>Prospective Studies</subject><subject>Rectal Cancer</subject><subject>Rectal Neoplasms - drug therapy</subject><subject>Rectal Neoplasms - radiotherapy</subject><subject>Rectal Neoplasms - surgery</subject><subject>Rectum - surgery</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Surgery</subject><subject>Survival Analysis</subject><subject>Thoracic Surgery</subject><subject>Total Mesorectal Excision</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><subject>Vascular Surgery</subject><issn>0364-2313</issn><issn>1432-2323</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkN2O0zAQhS0EYkvhAbhBFhKXgfFPHIcbVCrKjyotYkFcWo4z2fUqjbt2utW-Aw-NQyr2CnFla-Y7Z2YOIc8ZvGYA1ZsEwJUuAHRRlxwK9oAsmBS84IKLh2QBQsn8Z-KMPEnpGoBVCtRjcsa0EKB4tSC_LvZXfnAjxuJrxITx1g-X9HyP0Y4-DIluQt-H41TM_TDXb5Gur3AXom39H-wtXQ101WeXYW6Pga6aNuz8MEn8gLan37K9m2jahUi34Ygx19yYW2s7OIzvnpJHne0TPju9S_Jj8-H7-lOxPf_4eb3aFk7KWhdlV7qyYZ0oXdUg75RgunWcVxqhbkWjrGo75VqUomokCs0RUJVNK6WFSluxJC9n330MNwdMo7kOh7x6nwxndS21FJAhNkMuhpQidmYf_c7GO8PATPGbOX6T4zdT_IZlzYuT8aHZYXuvOOWdgVcnwCZn-y7mw336y3GQjCk2Da9n7uh7vPv_ZPPzy8X7DYg6T1oSPmtTlg2XGO-v-_fmvwFz5LBm</recordid><startdate>200806</startdate><enddate>200806</enddate><creator>Huh, Jung Wook</creator><creator>Jung, Eun Joo</creator><creator>Park, Yoon Ah</creator><creator>Lee, Kang Young</creator><creator>Sohn, Seung-Kook</creator><general>Springer-Verlag</general><general>Springer‐Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>200806</creationdate><title>Sphincter-Preserving Operations Following Preoperative Chemoradiation: An Alternative to Abdominoperineal Resection for Lower Rectal Cancer?</title><author>Huh, Jung Wook ; Jung, Eun Joo ; Park, Yoon Ah ; Lee, Kang Young ; Sohn, Seung-Kook</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4498-5f5c5b1f35c7be2f6318dc2278e09d3b6a6df6cde437b4e382e0e65bd44a078a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Abdominal Surgery</topic><topic>Adenocarcinoma - drug therapy</topic><topic>Adenocarcinoma - radiotherapy</topic><topic>Adenocarcinoma - surgery</topic><topic>Adult</topic><topic>Advanced Rectal Cancer</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anal Canal - surgery</topic><topic>Anterior Resection</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Cardiac Surgery</topic><topic>Colectomy - methods</topic><topic>Female</topic><topic>Fluorouracil - administration & dosage</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>General aspects</topic><topic>General Surgery</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoadjuvant Therapy</topic><topic>Oncologic Outcome</topic><topic>Prospective Studies</topic><topic>Rectal Cancer</topic><topic>Rectal Neoplasms - drug therapy</topic><topic>Rectal Neoplasms - radiotherapy</topic><topic>Rectal Neoplasms - surgery</topic><topic>Rectum - surgery</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Surgery</topic><topic>Survival Analysis</topic><topic>Thoracic Surgery</topic><topic>Total Mesorectal Excision</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huh, Jung Wook</creatorcontrib><creatorcontrib>Jung, Eun Joo</creatorcontrib><creatorcontrib>Park, Yoon Ah</creatorcontrib><creatorcontrib>Lee, Kang Young</creatorcontrib><creatorcontrib>Sohn, Seung-Kook</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>World journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huh, Jung Wook</au><au>Jung, Eun Joo</au><au>Park, Yoon Ah</au><au>Lee, Kang Young</au><au>Sohn, Seung-Kook</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sphincter-Preserving Operations Following Preoperative Chemoradiation: An Alternative to Abdominoperineal Resection for Lower Rectal Cancer?</atitle><jtitle>World journal of surgery</jtitle><stitle>World J Surg</stitle><addtitle>World J Surg</addtitle><date>2008-06</date><risdate>2008</risdate><volume>32</volume><issue>6</issue><spage>1116</spage><epage>1123</epage><pages>1116-1123</pages><issn>0364-2313</issn><eissn>1432-2323</eissn><coden>WJSUDI</coden><abstract>Background
Sphincter-preserving operations (SPO) for lower rectal cancer are on the rise. In the study reported here, we compared the oncologic outcomes of patients who underwent sphincter-preserving operations following preoperative chemoradiation for lower rectal cancer with the outcome for patients who underwent abdominoperineal resection (APR).
Methods
This prospective study included 87 patients who underwent proctectomy with curative intent for locally advanced rectal cancer that was located less than 6 cm from the anal verge. Forty-four patients had APR with no preoperative treatment. Forty-three patients underwent concurrent chemoradiation therapy (CCRT) consisting of preoperative 5-fluorouracil–based chemotherapy and pelvic radiation (4500–5040 cGy); this was followed 6 weeks later by surgery (SPO/CCRT). The oncologic outcomes between the two groups were compared, and factors affecting survival were evaluated.
Results
The median follow-up period was 56.2 months. The overall postoperative complication rates did not significantly differ between SPO/CCRT and APR (32.6% versus 34.2%;
p
= 0.879). Also, there were no significant differences in the overall recurrence rate (20.9% versus 20.5%;
p
= 0.956) and 5-year overall survival rate (70.8% versus 62.9%;
p
= 0.189) between the two groups. By multivariate analysis, only the pathologic N stage was significantly associated with overall survival (
p
< 0.001).
Conclusions
Sphincter-preserving operation with CCRT could be another option for the treatment of locally advanced lower rectal cancer in patients who are clinically considered for APR, with no deterioration of oncologic outcomes. For patients undergoing curative resection for lower rectal cancer, the pathologic N stage can provide valuable prognostic information about survival.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>18330627</pmid><doi>10.1007/s00268-008-9520-1</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0364-2313 |
| ispartof | World journal of surgery, 2008-06, Vol.32 (6), p.1116-1123 |
| issn | 0364-2313 1432-2323 |
| language | eng |
| recordid | cdi_proquest_journals_219948430 |
| source | MEDLINE; Wiley Online Library Journals; SpringerLink Journals - AutoHoldings |
| subjects | Abdominal Surgery Adenocarcinoma - drug therapy Adenocarcinoma - radiotherapy Adenocarcinoma - surgery Adult Advanced Rectal Cancer Aged Aged, 80 and over Anal Canal - surgery Anterior Resection Antineoplastic Agents - administration & dosage Biological and medical sciences Cardiac Surgery Colectomy - methods Female Fluorouracil - administration & dosage Gastroenterology. Liver. Pancreas. Abdomen General aspects General Surgery Humans Male Medical sciences Medicine Medicine & Public Health Middle Aged Neoadjuvant Therapy Oncologic Outcome Prospective Studies Rectal Cancer Rectal Neoplasms - drug therapy Rectal Neoplasms - radiotherapy Rectal Neoplasms - surgery Rectum - surgery Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Surgery Survival Analysis Thoracic Surgery Total Mesorectal Excision Treatment Outcome Tumors Vascular Surgery |
| title | Sphincter-Preserving Operations Following Preoperative Chemoradiation: An Alternative to Abdominoperineal Resection for Lower Rectal Cancer? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T15%3A15%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sphincter-Preserving%20Operations%20Following%20Preoperative%20Chemoradiation:%20An%20Alternative%20to%20Abdominoperineal%20Resection%20for%20Lower%20Rectal%20Cancer?&rft.jtitle=World%20journal%20of%20surgery&rft.au=Huh,%20Jung%20Wook&rft.date=2008-06&rft.volume=32&rft.issue=6&rft.spage=1116&rft.epage=1123&rft.pages=1116-1123&rft.issn=0364-2313&rft.eissn=1432-2323&rft.coden=WJSUDI&rft_id=info:doi/10.1007/s00268-008-9520-1&rft_dat=%3Cproquest_cross%3E1484772521%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=219948430&rft_id=info:pmid/18330627&rfr_iscdi=true |