Biofunctionalization of Ceramic Implant Surfaces to Improve their Bone Ingrowth Behavior

Surface biofunctionalization is a common strategy to improve the material-tissue interface of inert implant surfaces. In this context we coated alumina-toughened zirconia (ATZ) ceramics after titanium plasma spraying with two different porous calcium phosphate layers and subsequently functionalized...

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Veröffentlicht in:Materials science forum 2018-12, Vol.941, p.2483-2488
Hauptverfasser: Dubs, Manuela, Kautz, Armin R., Witt, Carolin, Nebe, J. Barbara, Rebl, Henrike, Weisser, Juergen, Schnabelrauch, Matthias, Bergemann, Claudia, Oberbach, Thomas, Imhof, Diana, Schmidt, Jürgen
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Sprache:eng
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Zusammenfassung:Surface biofunctionalization is a common strategy to improve the material-tissue interface of inert implant surfaces. In this context we coated alumina-toughened zirconia (ATZ) ceramics after titanium plasma spraying with two different porous calcium phosphate layers and subsequently functionalized the obtained surfaces either with an RGD containing cell adhesion peptide sequence or a bone morphogenetic protein (BMP)-glycosaminoglycan complex. We studied initial cell adhesion densities, integrin expression, and alkaline phosphatase activity as an osteogenic marker of the coatings in vitro in comparison to the non-functionalized ATZ ceramics to evaluate the bone ingrowth potential of these biofunctionalized implant coatings.
ISSN:0255-5476
1662-9752
1662-9752
DOI:10.4028/www.scientific.net/MSF.941.2483