Androgen signaling is essential for development of prostate cancer initiated from prostatic basal cells

Emerging evidence has shown that both prostatic basal and luminal cells are able to initiate oncogenic transformation. However, despite the diversity of tumor-initiating cells, most prostate cancer cells express the androgen receptor (AR) and depend on androgens for their growth and expansion, impli...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2019-03, Vol.38 (13), p.2337-2350
Hauptverfasser:	He, Yongfeng, Hooker, Erika, Yu, Eun-Jeong, Cunha, Gerald R., Liao, Lan, Xu, Jianming, Earl, Andrew, Wu, Huiqing, Gonzalgo, Michael L., Sun, Zijie
Format:	Artikel
Sprache:	eng
Schlagworte:	42/41 42/70 631/67/589/466 631/67/70 64/110 64/60 96 96/100 96/35 Androgen receptors Androgens Androgens - metabolism Androgens - physiology Animal models Animals Apoptosis Basal cell carcinoma Basal cells Cancer cells Cancer research Castration Cell Biology Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - pathology Development and progression Disease Progression Embryo, Mammalian Genetic transformation Human Genetics Humans Internal Medicine Male Medicine Medicine & Public Health Mice Mice, Inbred NOD Mice, SCID Mice, Transgenic Neoplastic Stem Cells - pathology Neoplastic Stem Cells - physiology Novels Oncology Patient outcomes Phenotypes Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Receptors, Androgen - physiology Sex hormones Signal Transduction - drug effects Signal Transduction - physiology Stromal Cells - pathology Stromal Cells - physiology Tumor cells Tumorigenesis Tumors β-Catenin
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!