Genetic variants in RPA1 associated with the response to oxaliplatin-based chemotherapy in colorectal cancer

Background Oxaliplatin (L-OHP) is a commonly used first-line chemotherapy for colorectal cancer. Genetic variants in nucleotide excision repair (NER) pathway genes may alter genomic integrity and the efficacy of oxaliplatin-based chemotherapy in colorectal cancer. Methods We investigated the associa...

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Veröffentlicht in:	Journal of gastroenterology 2019-11, Vol.54 (11), p.939-949
Hauptverfasser:	Li, Shuwei, Xu, Kaili, Gu, Dongying, He, Lei, Xie, Lisheng, Chen, Zhengxin, Fan, Zhimin, Zhu, Lingjun, Du, Mulong, Chu, Haiyan, Zhang, Zhengdong, Wu, Yuan, Ni, Min, Wang, Meilin
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Abdominal Surgery Alleles Analysis Antimitotic agents Antineoplastic agents Apoptosis Cancer Cell proliferation Chemotherapy Colon cancer Colorectal cancer Colorectal carcinoma Colorectal Surgery Development and progression Disease control DNA repair Gastroenterology Gene expression Genes Genetic aspects Genetic diversity Genotypes Hepatology Medicine Medicine & Public Health Nucleotide excision repair Original Article—Alimentary Tract Oxaliplatin Patients Phenotypes Quantitative genetics Quantitative trait loci RNA Single nucleotide polymorphisms Single-nucleotide polymorphism Surgical Oncology Tumorigenesis
Online-Zugang:	Volltext
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