A pharmacokinetic model for voriconazole in a highly diversified population of children and adolescents with cancer

Summary Background The wide pharmacokinetic variability of voriconazole leads to uncertainty regarding adequate exposure. Objectives To create a pharmacokinetic model that could help to explain the variability. Methods Retrospective review of paediatric patients with cancer. Models were built using...

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Veröffentlicht in:	Mycoses 2019-04, Vol.62 (4), p.399-404
Hauptverfasser:	Carlesse, Fabianne Altruda de Moraes Costa, Araujo, Orlei Ribeiro, Marques, Leticia Maria Acioli, Silva, Dafne Cardoso Bourguignon da, Senerchia, Andreza Almeida, Petrilli, Antonio Sergio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adolescents Antifungal Agents - administration & dosage Antifungal Agents - pharmacokinetics Bioavailability Cancer Child children Dosage Female Humans Invasiveness Male Mycoses - drug therapy Neoplasms - complications Pharmacokinetics Retrospective Studies Serum levels Voriconazole Voriconazole - administration & dosage Voriconazole - pharmacokinetics
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