Melatonin Enhances Proliferation and Modulates Differentiation of Neural Stem Cells Via Autophagy in Hyperglycemia

Dysfunction of neural stem cells (NSCs) has been linked to fetal neuropathy, one of the most devastating complications of gestational diabetes. Several studies have demonstrated that melatonin (Mel) exerted neuroprotective actions in various stresses. However, the role of autophagy and the involveme...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2019-04, Vol.37 (4), p.504-515
Hauptverfasser:	Li, Haoyuan, Zhang, Yanmin, Liu, Shangming, Li, Fengpeng, Wang, Benlin, Wang, Jianjie, Cao, Lanfang, Xia, Tongliang, Yao, Qingyu, Chen, Haijun, Zhang, Yulin, Zhu, Xiaodong, Li, Yang, Li, Gang, Wang, Jian, Li, Xingang, Ni, Shilei
Format:	Artikel
Sprache:	eng
Schlagworte:	Astrocytes Autophagy Autophagy - drug effects Cell Differentiation - drug effects Cell proliferation Cell Proliferation - drug effects Cell self-renewal Central nervous system Complications Diabetes Diabetes mellitus Diabetic neuropathy Differentiation Fetuses Glial fibrillary acidic protein Hyperglycemia Hyperglycemia - drug therapy Melatonin Mimicry Neural stem cells Neural Stem Cells - cytology Neural Stem Cells - metabolism Neuroprotection Phagocytosis Phagosomes Proliferation Rapamycin Signal Transduction Stem cells Supplements TOR protein
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