Microfluidic device fabricated by three‐dimensional lithography for observation of cancer cell invasion process
This paper describes a microfluidic device for observation of cancer cell invasion induced by chemotaxis. The developed device has two main channels, the channel filled with cell suspension and the channel filled with solution containing chemotactic factor. These channels are connected via tapered o...
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| Veröffentlicht in: | Electrical engineering in Japan 2019-04, Vol.207 (1), p.55-61 |
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| container_title | Electrical engineering in Japan |
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| creator | Tachikawa, Saeko Kaneda, Shohei Kumemura, Momoko Sato, Rui Tsukamoto, Takuya Fujii, Teruo Suzuki, Takaaki Fujita, Hiroyuki |
| description | This paper describes a microfluidic device for observation of cancer cell invasion induced by chemotaxis. The developed device has two main channels, the channel filled with cell suspension and the channel filled with solution containing chemotactic factor. These channels are connected via tapered orifice structures to capture multiple cancer cells in it to form cell clusters. Observation of cell invasions affected by cell adhesions is possible with this device. The devices were fabricated by using three‐dimensional lithography and PDMS (polydimethylsiloxane) molding. Invasion cells leaving the cell clusters and moving to the channel containing chemotactic factors through the orifices were successfully observed on the device. |
| doi_str_mv | 10.1002/eej.23190 |
| format | Article |
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The developed device has two main channels, the channel filled with cell suspension and the channel filled with solution containing chemotactic factor. These channels are connected via tapered orifice structures to capture multiple cancer cells in it to form cell clusters. Observation of cell invasions affected by cell adhesions is possible with this device. The devices were fabricated by using three‐dimensional lithography and PDMS (polydimethylsiloxane) molding. Invasion cells leaving the cell clusters and moving to the channel containing chemotactic factors through the orifices were successfully observed on the device.</description><identifier>ISSN: 0424-7760</identifier><identifier>EISSN: 1520-6416</identifier><identifier>DOI: 10.1002/eej.23190</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc</publisher><subject>Cancer ; cancer cell clusters ; cancer cell invasion ; Channels ; Clusters ; Lithography ; microfluidic device ; Microfluidic devices ; Molding (process) ; Orifices ; Polydimethylsiloxane ; Silicone resins ; soft lithography ; three‐dimensional lithography</subject><ispartof>Electrical engineering in Japan, 2019-04, Vol.207 (1), p.55-61</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><rights>2019 by Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3980-a3304fb739fc1a1ba3620691fef92548ed58176bf427bcc94cbf3fd4fca5d9663</citedby><cites>FETCH-LOGICAL-c3980-a3304fb739fc1a1ba3620691fef92548ed58176bf427bcc94cbf3fd4fca5d9663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Feej.23190$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Feej.23190$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Tachikawa, Saeko</creatorcontrib><creatorcontrib>Kaneda, Shohei</creatorcontrib><creatorcontrib>Kumemura, Momoko</creatorcontrib><creatorcontrib>Sato, Rui</creatorcontrib><creatorcontrib>Tsukamoto, Takuya</creatorcontrib><creatorcontrib>Fujii, Teruo</creatorcontrib><creatorcontrib>Suzuki, Takaaki</creatorcontrib><creatorcontrib>Fujita, Hiroyuki</creatorcontrib><title>Microfluidic device fabricated by three‐dimensional lithography for observation of cancer cell invasion process</title><title>Electrical engineering in Japan</title><description>This paper describes a microfluidic device for observation of cancer cell invasion induced by chemotaxis. The developed device has two main channels, the channel filled with cell suspension and the channel filled with solution containing chemotactic factor. These channels are connected via tapered orifice structures to capture multiple cancer cells in it to form cell clusters. Observation of cell invasions affected by cell adhesions is possible with this device. The devices were fabricated by using three‐dimensional lithography and PDMS (polydimethylsiloxane) molding. Invasion cells leaving the cell clusters and moving to the channel containing chemotactic factors through the orifices were successfully observed on the device.</description><subject>Cancer</subject><subject>cancer cell clusters</subject><subject>cancer cell invasion</subject><subject>Channels</subject><subject>Clusters</subject><subject>Lithography</subject><subject>microfluidic device</subject><subject>Microfluidic devices</subject><subject>Molding (process)</subject><subject>Orifices</subject><subject>Polydimethylsiloxane</subject><subject>Silicone resins</subject><subject>soft lithography</subject><subject>three‐dimensional lithography</subject><issn>0424-7760</issn><issn>1520-6416</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kLtOwzAUhi0EEqUw8AaWmBhSfEscj6gqNxWxwGzZzjF1lTatnRZl4xF4Rp6ElLAyneF8_3-OPoQuKZlQQtgNwHLCOFXkCI1ozkhWCFocoxERTGRSFuQUnaW0JIRIKssR2j4HFxtf70IVHK5gHxxgb2wMzrRQYdvhdhEBvj-_qrCCdQrN2tS4Du2ieY9ms-iwbyJubIK4N22_xY3HzqwdROygrnFY780hhTexcZDSOTrxpk5w8TfH6O1u9jp9yOYv94_T23nmuCpJZjgnwlvJlXfUUGt4wUihqAevWC5KqPKSysJ6waR1TglnPfeV8M7klSoKPkZXQ29_d7uD1Opls4v980kzqkqhJJe0p64HqreQUgSvNzGsTOw0JfpgVPdG9a_Rnr0Z2I9QQ_c_qGezpyHxA0OtewU</recordid><startdate>201904</startdate><enddate>201904</enddate><creator>Tachikawa, Saeko</creator><creator>Kaneda, Shohei</creator><creator>Kumemura, Momoko</creator><creator>Sato, Rui</creator><creator>Tsukamoto, Takuya</creator><creator>Fujii, Teruo</creator><creator>Suzuki, Takaaki</creator><creator>Fujita, Hiroyuki</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>L7M</scope></search><sort><creationdate>201904</creationdate><title>Microfluidic device fabricated by three‐dimensional lithography for observation of cancer cell invasion process</title><author>Tachikawa, Saeko ; Kaneda, Shohei ; Kumemura, Momoko ; Sato, Rui ; Tsukamoto, Takuya ; Fujii, Teruo ; Suzuki, Takaaki ; Fujita, Hiroyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3980-a3304fb739fc1a1ba3620691fef92548ed58176bf427bcc94cbf3fd4fca5d9663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Cancer</topic><topic>cancer cell clusters</topic><topic>cancer cell invasion</topic><topic>Channels</topic><topic>Clusters</topic><topic>Lithography</topic><topic>microfluidic device</topic><topic>Microfluidic devices</topic><topic>Molding (process)</topic><topic>Orifices</topic><topic>Polydimethylsiloxane</topic><topic>Silicone resins</topic><topic>soft lithography</topic><topic>three‐dimensional lithography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tachikawa, Saeko</creatorcontrib><creatorcontrib>Kaneda, Shohei</creatorcontrib><creatorcontrib>Kumemura, Momoko</creatorcontrib><creatorcontrib>Sato, Rui</creatorcontrib><creatorcontrib>Tsukamoto, Takuya</creatorcontrib><creatorcontrib>Fujii, Teruo</creatorcontrib><creatorcontrib>Suzuki, Takaaki</creatorcontrib><creatorcontrib>Fujita, Hiroyuki</creatorcontrib><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Electrical engineering in Japan</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tachikawa, Saeko</au><au>Kaneda, Shohei</au><au>Kumemura, Momoko</au><au>Sato, Rui</au><au>Tsukamoto, Takuya</au><au>Fujii, Teruo</au><au>Suzuki, Takaaki</au><au>Fujita, Hiroyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microfluidic device fabricated by three‐dimensional lithography for observation of cancer cell invasion process</atitle><jtitle>Electrical engineering in Japan</jtitle><date>2019-04</date><risdate>2019</risdate><volume>207</volume><issue>1</issue><spage>55</spage><epage>61</epage><pages>55-61</pages><issn>0424-7760</issn><eissn>1520-6416</eissn><abstract>This paper describes a microfluidic device for observation of cancer cell invasion induced by chemotaxis. The developed device has two main channels, the channel filled with cell suspension and the channel filled with solution containing chemotactic factor. These channels are connected via tapered orifice structures to capture multiple cancer cells in it to form cell clusters. Observation of cell invasions affected by cell adhesions is possible with this device. The devices were fabricated by using three‐dimensional lithography and PDMS (polydimethylsiloxane) molding. Invasion cells leaving the cell clusters and moving to the channel containing chemotactic factors through the orifices were successfully observed on the device.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/eej.23190</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Cancer cancer cell clusters cancer cell invasion Channels Clusters Lithography microfluidic device Microfluidic devices Molding (process) Orifices Polydimethylsiloxane Silicone resins soft lithography three‐dimensional lithography |
| title | Microfluidic device fabricated by three‐dimensional lithography for observation of cancer cell invasion process |
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