Comet assay and its use for evaluating oxidative DNA damage in some pathological states

The comet assay, or single-cell gel electrophoresis (SCGE), is a sensitive, rapid, relatively simple and inexpensive method for detecting DNA strand breaks in individual cells. It is used in a broad variety of applications and as a tool to investigate DNA damage and repair. The sensitivity and speci...

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Veröffentlicht in:	Physiological research 2019-01, Vol.68 (1), p.1-15
Hauptverfasser:	Kuchařová, M, Hronek, M, Rybáková, K, Zadák, Z, Štětina, R, Josková, V, Patková, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Bibliometrics Breast cancer Chemotherapy Clinical medicine Comet assay Coronary artery disease Deoxyribonucleic acid Disease DNA DNA damage DNA repair Gel electrophoresis Heart diseases Kinases Laboratories Lymphocytes Metabolism Methods Neurodegenerative diseases Oxidation Oxidative stress Radiation therapy Statistical analysis Studies Toxicology
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