Porous polyurethane film fabricated via the breath figure approach for sustained drug release
ABSTRACT The breath figure (BF) method is an effective process for fabricating porous polymeric films. In this study, we fabricated porous polymer films from thermoplastic polyurethane (PU) through static BF with CHCl3 as a solvent under 55–80% relative humidity. The porous PU films were prepared wi...
Gespeichert in:
| Veröffentlicht in: | Journal of applied polymer science 2019-07, Vol.136 (25), p.n/a |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | n/a |
|---|---|
| container_issue | 25 |
| container_start_page | |
| container_title | Journal of applied polymer science |
| container_volume | 136 |
| creator | Daban, Gizem Bayram, Cem Bozdoğan, Betül Denkbaş, Emir Baki |
| description | ABSTRACT
The breath figure (BF) method is an effective process for fabricating porous polymeric films. In this study, we fabricated porous polymer films from thermoplastic polyurethane (PU) through static BF with CHCl3 as a solvent under 55–80% relative humidity. The porous PU films were prepared within various pore structures and sizes, which were adjustable, depending on the fabrication conditions. The humidity and exposure time were examined as variable parameters affecting the surface morphology, wettability, and cytotoxicity. Atorvastatin calcium, a hyperlipidemic agent, was loaded into the porous films during the casting process, and the drug‐loading and drug‐releasing behaviors of the porous PU membranes were evaluated. Approximately 60–80% of the drug was released in 14 days. The films exhibited sustained drug‐release performances because of the hydrophobicity and nonbiodegradable nature of PU for perivascular drug administration. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47658. |
| doi_str_mv | 10.1002/app.47658 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2195911717</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2195911717</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4008-37684c314c79929fde6b5de36a27064711c5b1f32dc65877042dc37f9e1b01cd3</originalsourceid><addsrcrecordid>eNp1kMFOwzAMhiMEEmNw4A0iceLQLW7TpDlOEwykSewARxSlqbN16taStKC9PYFy5WRb_uzfvwm5BTYDxtK56boZlyIvzsgEmJIJF2lxTiaxB0mhVH5JrkLYMwaQMzEh75vWt0OgXducBo_9zhyRuro5UGdKX1vTY0U_a0P7HdLSo-l3sb2NKI1SvjU21q2nYQi9qY8RrvywpR4bNAGvyYUzTcCbvzglb48Pr8unZP2yel4u1onljBVJJkXBbQbcSqVS5SoUZV5hJkwqmeASwOYluCytbHQmJeMxy6RTCCUDW2VTcjfujRd9DBh6vW8Hf4ySOgWVKwAJMlL3I2V9G4JHpztfH4w_aWD653s6WtK_34vsfGS_6gZP_4N6sdmME982SXFP</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2195911717</pqid></control><display><type>article</type><title>Porous polyurethane film fabricated via the breath figure approach for sustained drug release</title><source>Wiley Online Library All Journals</source><creator>Daban, Gizem ; Bayram, Cem ; Bozdoğan, Betül ; Denkbaş, Emir Baki</creator><creatorcontrib>Daban, Gizem ; Bayram, Cem ; Bozdoğan, Betül ; Denkbaş, Emir Baki</creatorcontrib><description>ABSTRACT
The breath figure (BF) method is an effective process for fabricating porous polymeric films. In this study, we fabricated porous polymer films from thermoplastic polyurethane (PU) through static BF with CHCl3 as a solvent under 55–80% relative humidity. The porous PU films were prepared within various pore structures and sizes, which were adjustable, depending on the fabrication conditions. The humidity and exposure time were examined as variable parameters affecting the surface morphology, wettability, and cytotoxicity. Atorvastatin calcium, a hyperlipidemic agent, was loaded into the porous films during the casting process, and the drug‐loading and drug‐releasing behaviors of the porous PU membranes were evaluated. Approximately 60–80% of the drug was released in 14 days. The films exhibited sustained drug‐release performances because of the hydrophobicity and nonbiodegradable nature of PU for perivascular drug administration. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47658.</description><identifier>ISSN: 0021-8995</identifier><identifier>EISSN: 1097-4628</identifier><identifier>DOI: 10.1002/app.47658</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Chloroform ; Drug delivery systems ; Humidity ; Hydrophobicity ; Materials science ; Morphology ; Polymer films ; Polymers ; polyurethane ; Polyurethane resins ; porous materials ; Relative humidity ; self‐assembly ; Toxicity ; Wettability</subject><ispartof>Journal of applied polymer science, 2019-07, Vol.136 (25), p.n/a</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4008-37684c314c79929fde6b5de36a27064711c5b1f32dc65877042dc37f9e1b01cd3</citedby><cites>FETCH-LOGICAL-c4008-37684c314c79929fde6b5de36a27064711c5b1f32dc65877042dc37f9e1b01cd3</cites><orcidid>0000-0003-1546-3895 ; 0000-0002-2190-774X ; 0000-0001-9651-8645 ; 0000-0001-8717-4668</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fapp.47658$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fapp.47658$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Daban, Gizem</creatorcontrib><creatorcontrib>Bayram, Cem</creatorcontrib><creatorcontrib>Bozdoğan, Betül</creatorcontrib><creatorcontrib>Denkbaş, Emir Baki</creatorcontrib><title>Porous polyurethane film fabricated via the breath figure approach for sustained drug release</title><title>Journal of applied polymer science</title><description>ABSTRACT
The breath figure (BF) method is an effective process for fabricating porous polymeric films. In this study, we fabricated porous polymer films from thermoplastic polyurethane (PU) through static BF with CHCl3 as a solvent under 55–80% relative humidity. The porous PU films were prepared within various pore structures and sizes, which were adjustable, depending on the fabrication conditions. The humidity and exposure time were examined as variable parameters affecting the surface morphology, wettability, and cytotoxicity. Atorvastatin calcium, a hyperlipidemic agent, was loaded into the porous films during the casting process, and the drug‐loading and drug‐releasing behaviors of the porous PU membranes were evaluated. Approximately 60–80% of the drug was released in 14 days. The films exhibited sustained drug‐release performances because of the hydrophobicity and nonbiodegradable nature of PU for perivascular drug administration. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47658.</description><subject>Chloroform</subject><subject>Drug delivery systems</subject><subject>Humidity</subject><subject>Hydrophobicity</subject><subject>Materials science</subject><subject>Morphology</subject><subject>Polymer films</subject><subject>Polymers</subject><subject>polyurethane</subject><subject>Polyurethane resins</subject><subject>porous materials</subject><subject>Relative humidity</subject><subject>self‐assembly</subject><subject>Toxicity</subject><subject>Wettability</subject><issn>0021-8995</issn><issn>1097-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kMFOwzAMhiMEEmNw4A0iceLQLW7TpDlOEwykSewARxSlqbN16taStKC9PYFy5WRb_uzfvwm5BTYDxtK56boZlyIvzsgEmJIJF2lxTiaxB0mhVH5JrkLYMwaQMzEh75vWt0OgXducBo_9zhyRuro5UGdKX1vTY0U_a0P7HdLSo-l3sb2NKI1SvjU21q2nYQi9qY8RrvywpR4bNAGvyYUzTcCbvzglb48Pr8unZP2yel4u1onljBVJJkXBbQbcSqVS5SoUZV5hJkwqmeASwOYluCytbHQmJeMxy6RTCCUDW2VTcjfujRd9DBh6vW8Hf4ySOgWVKwAJMlL3I2V9G4JHpztfH4w_aWD653s6WtK_34vsfGS_6gZP_4N6sdmME982SXFP</recordid><startdate>20190705</startdate><enddate>20190705</enddate><creator>Daban, Gizem</creator><creator>Bayram, Cem</creator><creator>Bozdoğan, Betül</creator><creator>Denkbaş, Emir Baki</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0003-1546-3895</orcidid><orcidid>https://orcid.org/0000-0002-2190-774X</orcidid><orcidid>https://orcid.org/0000-0001-9651-8645</orcidid><orcidid>https://orcid.org/0000-0001-8717-4668</orcidid></search><sort><creationdate>20190705</creationdate><title>Porous polyurethane film fabricated via the breath figure approach for sustained drug release</title><author>Daban, Gizem ; Bayram, Cem ; Bozdoğan, Betül ; Denkbaş, Emir Baki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4008-37684c314c79929fde6b5de36a27064711c5b1f32dc65877042dc37f9e1b01cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Chloroform</topic><topic>Drug delivery systems</topic><topic>Humidity</topic><topic>Hydrophobicity</topic><topic>Materials science</topic><topic>Morphology</topic><topic>Polymer films</topic><topic>Polymers</topic><topic>polyurethane</topic><topic>Polyurethane resins</topic><topic>porous materials</topic><topic>Relative humidity</topic><topic>self‐assembly</topic><topic>Toxicity</topic><topic>Wettability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Daban, Gizem</creatorcontrib><creatorcontrib>Bayram, Cem</creatorcontrib><creatorcontrib>Bozdoğan, Betül</creatorcontrib><creatorcontrib>Denkbaş, Emir Baki</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Journal of applied polymer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Daban, Gizem</au><au>Bayram, Cem</au><au>Bozdoğan, Betül</au><au>Denkbaş, Emir Baki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Porous polyurethane film fabricated via the breath figure approach for sustained drug release</atitle><jtitle>Journal of applied polymer science</jtitle><date>2019-07-05</date><risdate>2019</risdate><volume>136</volume><issue>25</issue><epage>n/a</epage><issn>0021-8995</issn><eissn>1097-4628</eissn><abstract>ABSTRACT
The breath figure (BF) method is an effective process for fabricating porous polymeric films. In this study, we fabricated porous polymer films from thermoplastic polyurethane (PU) through static BF with CHCl3 as a solvent under 55–80% relative humidity. The porous PU films were prepared within various pore structures and sizes, which were adjustable, depending on the fabrication conditions. The humidity and exposure time were examined as variable parameters affecting the surface morphology, wettability, and cytotoxicity. Atorvastatin calcium, a hyperlipidemic agent, was loaded into the porous films during the casting process, and the drug‐loading and drug‐releasing behaviors of the porous PU membranes were evaluated. Approximately 60–80% of the drug was released in 14 days. The films exhibited sustained drug‐release performances because of the hydrophobicity and nonbiodegradable nature of PU for perivascular drug administration. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47658.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><doi>10.1002/app.47658</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-1546-3895</orcidid><orcidid>https://orcid.org/0000-0002-2190-774X</orcidid><orcidid>https://orcid.org/0000-0001-9651-8645</orcidid><orcidid>https://orcid.org/0000-0001-8717-4668</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8995 |
| ispartof | Journal of applied polymer science, 2019-07, Vol.136 (25), p.n/a |
| issn | 0021-8995 1097-4628 |
| language | eng |
| recordid | cdi_proquest_journals_2195911717 |
| source | Wiley Online Library All Journals |
| subjects | Chloroform Drug delivery systems Humidity Hydrophobicity Materials science Morphology Polymer films Polymers polyurethane Polyurethane resins porous materials Relative humidity self‐assembly Toxicity Wettability |
| title | Porous polyurethane film fabricated via the breath figure approach for sustained drug release |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T15%3A55%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Porous%20polyurethane%20film%20fabricated%20via%20the%20breath%20figure%20approach%20for%20sustained%20drug%20release&rft.jtitle=Journal%20of%20applied%20polymer%20science&rft.au=Daban,%20Gizem&rft.date=2019-07-05&rft.volume=136&rft.issue=25&rft.epage=n/a&rft.issn=0021-8995&rft.eissn=1097-4628&rft_id=info:doi/10.1002/app.47658&rft_dat=%3Cproquest_cross%3E2195911717%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2195911717&rft_id=info:pmid/&rfr_iscdi=true |