Local interstitial chemotherapy with sustained release bucladesine in de novo glioblastoma multiforme: a preliminary study

This clinical study was designed to evaluate the safety and efficacy of the sustained release form of dibutryl adenosine-3',5'-cyclic monophosphate (dB-cAMP, bucladesine) placed in the tumor resection cavity at the time of recurrence of the de novo glioblastoma multiforme (GBM) patients. I...

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Veröffentlicht in:	Journal of neuro-oncology 2002, Vol.56 (2), p.167-174
Hauptverfasser:	DALBASTI, Tayfun, OKTAR, Nezih, CAGLI, Sedat, OZDAMAR, Nurcan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antineoplastic agents Antineoplastic Agents - therapeutic use Biological and medical sciences Bone Marrow - drug effects Bucladesine - administration & dosage Bucladesine - adverse effects Bucladesine - therapeutic use Chemotherapy Delayed-Action Preparations Drug Implants - administration & dosage Drug Implants - adverse effects Drug Implants - therapeutic use Drug Therapy, Combination Female Glioblastoma - drug therapy Glioblastoma - mortality Glioblastoma - pathology Glioblastoma - surgery Humans Male Medical sciences Middle Aged Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - surgery Nitrosourea Compounds - therapeutic use Organophosphorus Compounds - therapeutic use Pharmacology. Drug treatments Prospective Studies Randomized Controlled Trials as Topic Surgical Wound Infection Survival Rate
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