Differing Effects of Copper, Zinc Superoxide Dismutase Overexpression on Neurotoxicity Elicited by Nitric Oxide, Reactive Oxygen Species, and Excitotoxins

Overexpression of Cu,Zn superoxide dismutase (SOD1) reduces ischemic injury in some stroke models but exacerbates injury in a neonatal stroke model and in other settings. The current study used a SOD1 transgenic (SOD1-Tg) murine cortical culture system, derived from the same mouse strain previously...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2000-02, Vol.20 (2), p.359-368
Hauptverfasser:	Ying, Weihai, Anderson, Christopher M., Chen, Yongmei, Stein, Becky A., Fahlman, Christian S., Copin, Jean-Christophe, Chan, Pak H., Swanson, Raymond A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - cytology Biological and medical sciences Cell Death - physiology Cells, Cultured Cerebral Cortex - cytology Excitatory Amino Acid Agonists - pharmacology Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Enzymologic - physiology Glutamic Acid - metabolism Glutamic Acid - pharmacology Humans Hydrazines - pharmacology Kainic Acid - pharmacology Medical sciences Mice Mice, Transgenic N-Methylaspartate - pharmacology Neurology Neurons - chemistry Neurons - cytology Neurons - enzymology Neurotoxins - metabolism Nitric Oxide - metabolism Nitric Oxide Donors - pharmacology Nitrogen Oxides Penicillamine - analogs & derivatives Penicillamine - pharmacology Reactive Oxygen Species - metabolism Spermine - analogs & derivatives Spermine - pharmacology Superoxide Dismutase - genetics Tyrosine - analogs & derivatives Tyrosine - analysis Vascular diseases and vascular malformations of the nervous system Vitamin K - pharmacology
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