Hydroxyfasudil, an Active Metabolite of Fasudil Hydrochloride, Relaxes the Rabbit Basilar Artery by Disinhibition of Myosin Light Chain Phosphatase

Fasudil hydrochloride (AT877, hexahydro-1-(5-isoquinolinesulfonyl)-1H-1,4-diazepine hydrochloride, identical to HA1077) inhibits cerebral vasospasm after subarachnoid hemorrhage in experimental animals and humans. In the current study, the vasorelaxing mechanism of hydroxyfasudil, a hydroxylated met...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2001-07, Vol.21 (7), p.876-885
Hauptverfasser:	Nakamura, Kensei, Nishimura, Junji, Hirano, Katsuya, Ibayashi, Setsuro, Fujishima, Masatoshi, Kanaide, Hideo
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - metabolism 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology Adenosine Triphosphate - administration & dosage Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - pharmacology Animals Basilar Artery - drug effects Basilar Artery - physiology Biological and medical sciences Calcium - metabolism Calcium - pharmacology Cardiovascular system Endothelin-1 - pharmacology Enzyme Activation - drug effects Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology Kinetics Male Medical sciences Muscle Contraction - drug effects Muscle Relaxation - drug effects Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology Myosin-Light-Chain Phosphatase Pharmacology. Drug treatments Phorbol 12,13-Dibutyrate - pharmacology Phosphoprotein Phosphatases - metabolism Protein Kinase C - metabolism Rabbits Vasodilator Agents - pharmacology Vasodilator agents. Cerebral vasodilators
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