Olfactory Response in the Temporal Cortex of the Elderly Measured with Near-Infrared Spectroscopy: A Preliminary Feasibility Study
The pathway for the olfactory response may be affected at an early stage of Alzheimer's disease. Measurement of the olfactory response in the elderly is therefore of particular interest. In this feasibility study, near-infrared spectroscopy was used to measure the olfactory response in 21 patie...
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| Veröffentlicht in: | Journal of cerebral blood flow and metabolism 2004-06, Vol.24 (6), p.677-680 |
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| container_title | Journal of cerebral blood flow and metabolism |
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| creator | Fladby, Tormod Bryhn, Grete Halvorsen, Ola Rosé, Isabelle Wahlund, Martin Wiig, Pia Wetterberg, Lennart |
| description | The pathway for the olfactory response may be affected at an early stage of Alzheimer's disease. Measurement of the olfactory response in the elderly is therefore of particular interest. In this feasibility study, near-infrared spectroscopy was used to measure the olfactory response in 21 patients aged 56 to 79 years. Eight subjects had no memory complaints whereas 13 had subjective memory complaints, mild cognitive impairment, or very mild Alzheimer's disease. The optodes were placed over the temporal lobe, with the emitting optode over the pole and the receiving optode over the superior gyrus. The response to vanilla (1% in sterile H2O) in a test tube held immediately beneath the nostrils was compared to the response to sterile H2O only. Four control subjects had a clearly definable response with increased oxyhemoglobin and decreased deoxyhemoglobin bilaterally. The response was measured as the sum of the deviation of oxygenated and deoxygenated hemoglobin from baseline mean. With a cut-off determined after examination of responses to vanilla and sham stimulus, group difference was significant for response to vanilla (χ2 test, P = 0.03). Response amplitudes to vanilla in the patient group were within the range of those to sham stimuli. |
| doi_str_mv | 10.1097/01.WCB.0000119966.74298.5C |
| format | Article |
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Measurement of the olfactory response in the elderly is therefore of particular interest. In this feasibility study, near-infrared spectroscopy was used to measure the olfactory response in 21 patients aged 56 to 79 years. Eight subjects had no memory complaints whereas 13 had subjective memory complaints, mild cognitive impairment, or very mild Alzheimer's disease. The optodes were placed over the temporal lobe, with the emitting optode over the pole and the receiving optode over the superior gyrus. The response to vanilla (1% in sterile H2O) in a test tube held immediately beneath the nostrils was compared to the response to sterile H2O only. Four control subjects had a clearly definable response with increased oxyhemoglobin and decreased deoxyhemoglobin bilaterally. The response was measured as the sum of the deviation of oxygenated and deoxygenated hemoglobin from baseline mean. With a cut-off determined after examination of responses to vanilla and sham stimulus, group difference was significant for response to vanilla (χ2 test, P = 0.03). Response amplitudes to vanilla in the patient group were within the range of those to sham stimuli.</description><identifier>ISSN: 0271-678X</identifier><identifier>EISSN: 1559-7016</identifier><identifier>DOI: 10.1097/01.WCB.0000119966.74298.5C</identifier><identifier>PMID: 15181375</identifier><identifier>CODEN: JCBMDN</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Aged ; Alzheimer Disease - diagnosis ; Alzheimer Disease - physiopathology ; Biological and medical sciences ; Cerebrovascular Circulation ; Cognition Disorders - physiopathology ; Feasibility Studies ; Female ; Hemoglobins - metabolism ; Humans ; Male ; Medical sciences ; Memory Disorders - physiopathology ; Middle Aged ; Neurology ; Neuropsychological Tests ; Odorants ; Oxyhemoglobins - metabolism ; Smell - physiology ; Spectroscopy, Near-Infrared ; Temporal Lobe - metabolism ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Journal of cerebral blood flow and metabolism, 2004-06, Vol.24 (6), p.677-680</ispartof><rights>2004 The International Society of Cerebral Blood Flow and Metabolism</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Jun 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-7b228082d221696df7b6b1959e10f47d3973eb8751b9a10b50215da1b7f683883</citedby><cites>FETCH-LOGICAL-c441t-7b228082d221696df7b6b1959e10f47d3973eb8751b9a10b50215da1b7f683883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1097/01.WCB.0000119966.74298.5C$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1097/01.WCB.0000119966.74298.5C$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15849614$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15181375$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fladby, Tormod</creatorcontrib><creatorcontrib>Bryhn, Grete</creatorcontrib><creatorcontrib>Halvorsen, Ola</creatorcontrib><creatorcontrib>Rosé, Isabelle</creatorcontrib><creatorcontrib>Wahlund, Martin</creatorcontrib><creatorcontrib>Wiig, Pia</creatorcontrib><creatorcontrib>Wetterberg, Lennart</creatorcontrib><title>Olfactory Response in the Temporal Cortex of the Elderly Measured with Near-Infrared Spectroscopy: A Preliminary Feasibility Study</title><title>Journal of cerebral blood flow and metabolism</title><addtitle>J Cereb Blood Flow Metab</addtitle><description>The pathway for the olfactory response may be affected at an early stage of Alzheimer's disease. Measurement of the olfactory response in the elderly is therefore of particular interest. In this feasibility study, near-infrared spectroscopy was used to measure the olfactory response in 21 patients aged 56 to 79 years. Eight subjects had no memory complaints whereas 13 had subjective memory complaints, mild cognitive impairment, or very mild Alzheimer's disease. The optodes were placed over the temporal lobe, with the emitting optode over the pole and the receiving optode over the superior gyrus. The response to vanilla (1% in sterile H2O) in a test tube held immediately beneath the nostrils was compared to the response to sterile H2O only. Four control subjects had a clearly definable response with increased oxyhemoglobin and decreased deoxyhemoglobin bilaterally. The response was measured as the sum of the deviation of oxygenated and deoxygenated hemoglobin from baseline mean. 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Bryhn, Grete ; Halvorsen, Ola ; Rosé, Isabelle ; Wahlund, Martin ; Wiig, Pia ; Wetterberg, Lennart</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-7b228082d221696df7b6b1959e10f47d3973eb8751b9a10b50215da1b7f683883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Aged</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer Disease - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Cerebrovascular Circulation</topic><topic>Cognition Disorders - physiopathology</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Hemoglobins - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory Disorders - physiopathology</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Odorants</topic><topic>Oxyhemoglobins - metabolism</topic><topic>Smell - physiology</topic><topic>Spectroscopy, Near-Infrared</topic><topic>Temporal Lobe - metabolism</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fladby, Tormod</creatorcontrib><creatorcontrib>Bryhn, Grete</creatorcontrib><creatorcontrib>Halvorsen, Ola</creatorcontrib><creatorcontrib>Rosé, Isabelle</creatorcontrib><creatorcontrib>Wahlund, Martin</creatorcontrib><creatorcontrib>Wiig, Pia</creatorcontrib><creatorcontrib>Wetterberg, Lennart</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Journal of cerebral blood flow and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fladby, Tormod</au><au>Bryhn, Grete</au><au>Halvorsen, Ola</au><au>Rosé, Isabelle</au><au>Wahlund, Martin</au><au>Wiig, Pia</au><au>Wetterberg, Lennart</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Olfactory Response in the Temporal Cortex of the Elderly Measured with Near-Infrared Spectroscopy: A Preliminary Feasibility Study</atitle><jtitle>Journal of cerebral blood flow and metabolism</jtitle><addtitle>J Cereb Blood Flow Metab</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>24</volume><issue>6</issue><spage>677</spage><epage>680</epage><pages>677-680</pages><issn>0271-678X</issn><eissn>1559-7016</eissn><coden>JCBMDN</coden><abstract>The pathway for the olfactory response may be affected at an early stage of Alzheimer's disease. Measurement of the olfactory response in the elderly is therefore of particular interest. In this feasibility study, near-infrared spectroscopy was used to measure the olfactory response in 21 patients aged 56 to 79 years. Eight subjects had no memory complaints whereas 13 had subjective memory complaints, mild cognitive impairment, or very mild Alzheimer's disease. The optodes were placed over the temporal lobe, with the emitting optode over the pole and the receiving optode over the superior gyrus. The response to vanilla (1% in sterile H2O) in a test tube held immediately beneath the nostrils was compared to the response to sterile H2O only. Four control subjects had a clearly definable response with increased oxyhemoglobin and decreased deoxyhemoglobin bilaterally. The response was measured as the sum of the deviation of oxygenated and deoxygenated hemoglobin from baseline mean. With a cut-off determined after examination of responses to vanilla and sham stimulus, group difference was significant for response to vanilla (χ2 test, P = 0.03). Response amplitudes to vanilla in the patient group were within the range of those to sham stimuli.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>15181375</pmid><doi>10.1097/01.WCB.0000119966.74298.5C</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Alzheimer Disease - diagnosis Alzheimer Disease - physiopathology Biological and medical sciences Cerebrovascular Circulation Cognition Disorders - physiopathology Feasibility Studies Female Hemoglobins - metabolism Humans Male Medical sciences Memory Disorders - physiopathology Middle Aged Neurology Neuropsychological Tests Odorants Oxyhemoglobins - metabolism Smell - physiology Spectroscopy, Near-Infrared Temporal Lobe - metabolism Vascular diseases and vascular malformations of the nervous system |
| title | Olfactory Response in the Temporal Cortex of the Elderly Measured with Near-Infrared Spectroscopy: A Preliminary Feasibility Study |
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