Valproate is Neuroprotective against Malonate Toxicity in Rat Striatum: An Association with Augmentation of High-Affinity Glutamate Uptake

The antiepileptic drug valproate (VPA) may be neuroprotective. We treated rats with VPA for 14 days (300 mg/kg twice daily) before intrastriatal injection of 1.5 μmol (1 M) of the succinate dehydrogenase inhibitor malonate. VPA-treated animals developed smaller lesions than control animals: 10 ± 2 m...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2004-11, Vol.24 (11), p.1226-1234
Hauptverfasser:	Morland, Cecilie, Boldingh, Karen Astrid, Iversen, Evy Grini, Hassel, Bjørnar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Biological and medical sciences Biological Transport - drug effects Blood and lymphatic vessels Carbon Radioisotopes Cardiology. Vascular system Cell Death - drug effects Deoxyglucose - chemistry Deoxyglucose - metabolism Diseases of the aorta Dopamine - pharmacology Glutamic Acid - metabolism Histones - metabolism HSP70 Heat-Shock Proteins - metabolism Male Malonates - antagonists & inhibitors Malonates - chemistry Malonates - toxicity Medical sciences Mitogen-Activated Protein Kinases - metabolism Neostriatum - drug effects Neostriatum - pathology Neurology Neurons - drug effects Neurons - metabolism Neurons - pathology Neuropharmacology Neuroprotective agent Neuroprotective Agents - pharmacology Pharmacology. Drug treatments Phosphorylation - drug effects Proto-Oncogene Proteins c-bcl-2 - metabolism Proto-Oncogene Proteins c-fos - metabolism Rats Rats, Wistar Valproic Acid - pharmacology Vascular diseases and vascular malformations of the nervous system Weight Gain - drug effects
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