Loss of endothelium-dependent relaxation in abdominal aorta preserved in a co-storage system
The potentially detrimental influence of parenchymal cells on endothelial function during preservation in UW solution was examined by co-storage of rat abdominal aortic rings with isolated liver cells. Cold storage of rings in UW solution alone for up to 96 h had no effect on the response to acetylc...
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| Veröffentlicht in: | Transplant international 2005-01, Vol.17 (11), p.699-706 |
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| creator | KNES, Jane M HANSEN, Thomas N GILLIGAN, Barbara WOO, Heung MANGINO, Martin HAWORTH, Robert A SOUTHARD, James H |
| description | The potentially detrimental influence of parenchymal cells on endothelial function during preservation in UW solution was examined by co-storage of rat abdominal aortic rings with isolated liver cells. Cold storage of rings in UW solution alone for up to 96 h had no effect on the response to acetylcholine, though constriction was progressively lost. Co-storage of rings with liver cells resulted in no loss of sodium nitroprusside response, but the relaxation response to acetylcholine was reduced. The loss of acetylcholine response could not be attributed to Kupffer cells, the lowering of pH, oxygen depletion, or the loss of constriction. A similar loss of endothelial function was observed in rings stored in pieces of liver, kidney or heart. We conclude that parenchymal cells exude factors during preservation by cold storage which reversibly inhibit vascular NO production. These factors could significantly impair whole organ function on reperfusion. |
| doi_str_mv | 10.1007/s00147-004-0788-2 |
| format | Article |
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Cold storage of rings in UW solution alone for up to 96 h had no effect on the response to acetylcholine, though constriction was progressively lost. Co-storage of rings with liver cells resulted in no loss of sodium nitroprusside response, but the relaxation response to acetylcholine was reduced. The loss of acetylcholine response could not be attributed to Kupffer cells, the lowering of pH, oxygen depletion, or the loss of constriction. A similar loss of endothelial function was observed in rings stored in pieces of liver, kidney or heart. We conclude that parenchymal cells exude factors during preservation by cold storage which reversibly inhibit vascular NO production. These factors could significantly impair whole organ function on reperfusion.</description><identifier>ISSN: 0934-0874</identifier><identifier>EISSN: 1432-2277</identifier><identifier>DOI: 10.1007/s00147-004-0788-2</identifier><identifier>PMID: 15551051</identifier><language>eng</language><publisher>Oxford: Blackwell Publishing</publisher><subject>15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology ; Acetylcholine - pharmacology ; Adenosine - pharmacology ; Allopurinol - pharmacology ; Animals ; Aorta, Abdominal - drug effects ; Aorta, Abdominal - pathology ; Aorta, Abdominal - physiopathology ; Biological and medical sciences ; Cryopreservation ; Drug Synergism ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - physiopathology ; Glutathione - pharmacology ; Hepatocytes ; Hydrogen-Ion Concentration ; In Vitro Techniques ; Insulin - pharmacology ; Kupffer Cells ; Liver - physiopathology ; Male ; Medical sciences ; Nephrology. Urinary tract diseases ; Nitroprusside - pharmacology ; Organ Preservation - adverse effects ; Organ Preservation - methods ; Organ Preservation Solutions - pharmacology ; Pharmacology. 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These factors could significantly impair whole organ function on reperfusion.</description><subject>15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology</subject><subject>Acetylcholine - pharmacology</subject><subject>Adenosine - pharmacology</subject><subject>Allopurinol - pharmacology</subject><subject>Animals</subject><subject>Aorta, Abdominal - drug effects</subject><subject>Aorta, Abdominal - pathology</subject><subject>Aorta, Abdominal - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Cryopreservation</subject><subject>Drug Synergism</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Glutathione - pharmacology</subject><subject>Hepatocytes</subject><subject>Hydrogen-Ion Concentration</subject><subject>In Vitro Techniques</subject><subject>Insulin - pharmacology</subject><subject>Kupffer Cells</subject><subject>Liver - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nitroprusside - pharmacology</subject><subject>Organ Preservation - adverse effects</subject><subject>Organ Preservation - methods</subject><subject>Organ Preservation Solutions - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Raffinose - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Time Factors</subject><subject>Vasodilation</subject><subject>Vasodilator Agents - pharmacology</subject><issn>0934-0874</issn><issn>1432-2277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1rHDEMhk1paLZJf0AvwRR6dCN77LF9DKFfsJBLcgsYeyy3E2bGG3s2JP--TnchJyH0vEJ6CPnM4RsH0JcVgEvNACQDbQwT78iGy04wIbR-TzZguzYxWp6Sj7U-AIAwCj6QU66U4qD4htxvc600J4pLzOtfnMb9zCLuWovLSgtO_tmvY17ouFAfYp7HxU_U57J6uitYsTxh_D-kQ2Z1zcX_QVpf6orzOTlJfqr46VjPyN2P77fXv9j25ufv66stG4TmK8PQSw-d8hqtxRS5kKYPIkQrREgNMTwooaT3EawyIlkTIyZugg3JB96dkS-HvbuSH_dYV_eQ96XdWZ3gVnUAyjaIH6ChtJcLJrcr4-zLi-PgXnW6g07XdLpXnU60zMVx8T7MGN8SR38N-HoEfB38lIpfhrG-cb3spdZ99w_cLX32</recordid><startdate>200501</startdate><enddate>200501</enddate><creator>KNES, Jane M</creator><creator>HANSEN, Thomas N</creator><creator>GILLIGAN, Barbara</creator><creator>WOO, Heung</creator><creator>MANGINO, Martin</creator><creator>HAWORTH, Robert A</creator><creator>SOUTHARD, James H</creator><general>Blackwell Publishing</general><general>Blackwell Publishing Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope></search><sort><creationdate>200501</creationdate><title>Loss of endothelium-dependent relaxation in abdominal aorta preserved in a co-storage system</title><author>KNES, Jane M ; HANSEN, Thomas N ; GILLIGAN, Barbara ; WOO, Heung ; MANGINO, Martin ; HAWORTH, Robert A ; SOUTHARD, James H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c271t-eb64a035a7e99efd12486b2bd922bf27181b5254aad09582f98ddef18b9bfab13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology</topic><topic>Acetylcholine - pharmacology</topic><topic>Adenosine - pharmacology</topic><topic>Allopurinol - pharmacology</topic><topic>Animals</topic><topic>Aorta, Abdominal - drug effects</topic><topic>Aorta, Abdominal - pathology</topic><topic>Aorta, Abdominal - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Cryopreservation</topic><topic>Drug Synergism</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Glutathione - pharmacology</topic><topic>Hepatocytes</topic><topic>Hydrogen-Ion Concentration</topic><topic>In Vitro Techniques</topic><topic>Insulin - pharmacology</topic><topic>Kupffer Cells</topic><topic>Liver - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nitroprusside - pharmacology</topic><topic>Organ Preservation - adverse effects</topic><topic>Organ Preservation - methods</topic><topic>Organ Preservation Solutions - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Raffinose - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Time Factors</topic><topic>Vasodilation</topic><topic>Vasodilator Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KNES, Jane M</creatorcontrib><creatorcontrib>HANSEN, Thomas N</creatorcontrib><creatorcontrib>GILLIGAN, Barbara</creatorcontrib><creatorcontrib>WOO, Heung</creatorcontrib><creatorcontrib>MANGINO, Martin</creatorcontrib><creatorcontrib>HAWORTH, Robert A</creatorcontrib><creatorcontrib>SOUTHARD, James H</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Transplant international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KNES, Jane M</au><au>HANSEN, Thomas N</au><au>GILLIGAN, Barbara</au><au>WOO, Heung</au><au>MANGINO, Martin</au><au>HAWORTH, Robert A</au><au>SOUTHARD, James H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Loss of endothelium-dependent relaxation in abdominal aorta preserved in a co-storage system</atitle><jtitle>Transplant international</jtitle><addtitle>Transpl Int</addtitle><date>2005-01</date><risdate>2005</risdate><volume>17</volume><issue>11</issue><spage>699</spage><epage>706</epage><pages>699-706</pages><issn>0934-0874</issn><eissn>1432-2277</eissn><abstract>The potentially detrimental influence of parenchymal cells on endothelial function during preservation in UW solution was examined by co-storage of rat abdominal aortic rings with isolated liver cells. Cold storage of rings in UW solution alone for up to 96 h had no effect on the response to acetylcholine, though constriction was progressively lost. Co-storage of rings with liver cells resulted in no loss of sodium nitroprusside response, but the relaxation response to acetylcholine was reduced. The loss of acetylcholine response could not be attributed to Kupffer cells, the lowering of pH, oxygen depletion, or the loss of constriction. A similar loss of endothelial function was observed in rings stored in pieces of liver, kidney or heart. We conclude that parenchymal cells exude factors during preservation by cold storage which reversibly inhibit vascular NO production. These factors could significantly impair whole organ function on reperfusion.</abstract><cop>Oxford</cop><pub>Blackwell Publishing</pub><pmid>15551051</pmid><doi>10.1007/s00147-004-0788-2</doi><tpages>8</tpages></addata></record> |
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| subjects | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology Acetylcholine - pharmacology Adenosine - pharmacology Allopurinol - pharmacology Animals Aorta, Abdominal - drug effects Aorta, Abdominal - pathology Aorta, Abdominal - physiopathology Biological and medical sciences Cryopreservation Drug Synergism Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Glutathione - pharmacology Hepatocytes Hydrogen-Ion Concentration In Vitro Techniques Insulin - pharmacology Kupffer Cells Liver - physiopathology Male Medical sciences Nephrology. Urinary tract diseases Nitroprusside - pharmacology Organ Preservation - adverse effects Organ Preservation - methods Organ Preservation Solutions - pharmacology Pharmacology. Drug treatments Raffinose - pharmacology Rats Rats, Sprague-Dawley Time Factors Vasodilation Vasodilator Agents - pharmacology |
| title | Loss of endothelium-dependent relaxation in abdominal aorta preserved in a co-storage system |
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