A novel strategy to achieve effective drug delivery: exploit cells as carrier combined with nanoparticles
Cell-mediated drug delivery systems employ specific cells as drug vehicles to deliver drugs to targeted sites. Therapeutics or imaging agents are loaded into these cells and then released in diseased sites. These specific cells mainly include red blood cells, leukocytes, stem cells and so on. The ce...
Gespeichert in:
| Veröffentlicht in: | Drug delivery 2017-01, Vol.24 (1), p.83-91 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 91 |
|---|---|
| container_issue | 1 |
| container_start_page | 83 |
| container_title | Drug delivery |
| container_volume | 24 |
| creator | Pang, Liang Zhang, Chun Qin, Jing Han, Limei Li, Ruixiang Hong, Chao He, Huining Wang, Jianxin |
| description | Cell-mediated drug delivery systems employ specific cells as drug vehicles to deliver drugs to targeted sites. Therapeutics or imaging agents are loaded into these cells and then released in diseased sites. These specific cells mainly include red blood cells, leukocytes, stem cells and so on. The cell acts as a Trojan horse to transfer the drug from circulating blood to the diseased tissue. In such a system, these cells keep their original properties, which allow them to mimic the migration behavior of specific cells to carry drug to the targeted site after in vivo administration. This strategy elegantly combines the advantages of both carriers, i.e. the adjustability of nanoparticles (NPs) and the natural functions of active cells, which therefore provides a new perspective to challenge current obstacles in drug delivery. This review will describe a fundamental understanding of these cell-based drug delivery systems, and discuss the great potential of combinational application of cell carrier and NPs. |
| doi_str_mv | 10.1080/10717544.2016.1230903 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_journals_2195232001</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_c9e8d181c0114ba4ac19bb5cfa2548ad</doaj_id><sourcerecordid>2195232001</sourcerecordid><originalsourceid>FETCH-LOGICAL-c562t-da2c945948e1c4ee17e00f5dcbaf83a06dd3a49725f0be0233d591c025f48d4d3</originalsourceid><addsrcrecordid>eNp9kU9vEzEQxVcIREvhI4AscU7q8Z_EywFRVUArVeICZ2vWHieONutgb9Lm2-OQtKIXTn62f_Nm7Nc074FPgRt-CXwOc63UVHCYTUFI3nL5ojkHLWDC1Uy9rLoykwN01rwpZcU5NyD06-ZMGNBaS3PexCs2pB31rIwZR1rs2ZgYumWkHTEKgdwYq_J5u2Ce-qrz_hOjh02f4sgc9X1hWJjDnCNl5tK6iwN5dh_HJRtwSBvMY3Q9lbfNq4B9oXen9aL59e3rz-ubyd2P77fXV3cTp2dinHgUrlW6VYbAKSKYE-dBe9dhMBL5zHuJqp0LHXhHXEjpdQuO170yXnl50dwefX3Cld3kuMa8twmj_XuQ8sKeRrKuJePB1GoA1aFCB23XaRdQaGXw4PX56LXZdmvyjob6S_0z0-c3Q1zaRdpZIxSAbqvBx5NBTr-3VEa7Sts81PdbAa0WUnAOldJHyuVUSqbw1AG4PaRtH9O2h7TtKe1a9-Hf8Z6qHuOtwJcjEIeQ8hrvU-69HXHfpxwyDi4WK__f4w9D67ue</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2195232001</pqid></control><display><type>article</type><title>A novel strategy to achieve effective drug delivery: exploit cells as carrier combined with nanoparticles</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Access via Taylor & Francis (Open Access Collection)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Pang, Liang ; Zhang, Chun ; Qin, Jing ; Han, Limei ; Li, Ruixiang ; Hong, Chao ; He, Huining ; Wang, Jianxin</creator><creatorcontrib>Pang, Liang ; Zhang, Chun ; Qin, Jing ; Han, Limei ; Li, Ruixiang ; Hong, Chao ; He, Huining ; Wang, Jianxin</creatorcontrib><description>Cell-mediated drug delivery systems employ specific cells as drug vehicles to deliver drugs to targeted sites. Therapeutics or imaging agents are loaded into these cells and then released in diseased sites. These specific cells mainly include red blood cells, leukocytes, stem cells and so on. The cell acts as a Trojan horse to transfer the drug from circulating blood to the diseased tissue. In such a system, these cells keep their original properties, which allow them to mimic the migration behavior of specific cells to carry drug to the targeted site after in vivo administration. This strategy elegantly combines the advantages of both carriers, i.e. the adjustability of nanoparticles (NPs) and the natural functions of active cells, which therefore provides a new perspective to challenge current obstacles in drug delivery. This review will describe a fundamental understanding of these cell-based drug delivery systems, and discuss the great potential of combinational application of cell carrier and NPs.</description><identifier>ISSN: 1071-7544</identifier><identifier>EISSN: 1521-0464</identifier><identifier>DOI: 10.1080/10717544.2016.1230903</identifier><identifier>PMID: 28155538</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Animals ; carrier ; Drug Carriers ; Drug Compounding ; Drug delivery systems ; Drug Delivery Systems - methods ; Erythrocyte Transfusion ; Erythrocytes - metabolism ; Humans ; leukocyte ; Leukocyte Transfusion ; Leukocytes - metabolism ; Nanomedicine ; nanoparticle ; Nanoparticles ; Pharmaceutical Preparations - administration & dosage ; Pharmaceutical Preparations - chemistry ; Pharmaceutical Preparations - metabolism ; Red blood cell ; Review ; stem cell ; Stem Cell Transplantation ; Stem Cells - metabolism ; Technology, Pharmaceutical - methods ; Time Factors ; Tissue Distribution ; Transdermal medication</subject><ispartof>Drug delivery, 2017-01, Vol.24 (1), p.83-91</ispartof><rights>2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2017</rights><rights>2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/Licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2017 The Author(s).</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c562t-da2c945948e1c4ee17e00f5dcbaf83a06dd3a49725f0be0233d591c025f48d4d3</citedby><cites>FETCH-LOGICAL-c562t-da2c945948e1c4ee17e00f5dcbaf83a06dd3a49725f0be0233d591c025f48d4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241159/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241159/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,27502,27924,27925,53791,53793,59143,59144</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28155538$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pang, Liang</creatorcontrib><creatorcontrib>Zhang, Chun</creatorcontrib><creatorcontrib>Qin, Jing</creatorcontrib><creatorcontrib>Han, Limei</creatorcontrib><creatorcontrib>Li, Ruixiang</creatorcontrib><creatorcontrib>Hong, Chao</creatorcontrib><creatorcontrib>He, Huining</creatorcontrib><creatorcontrib>Wang, Jianxin</creatorcontrib><title>A novel strategy to achieve effective drug delivery: exploit cells as carrier combined with nanoparticles</title><title>Drug delivery</title><addtitle>Drug Deliv</addtitle><description>Cell-mediated drug delivery systems employ specific cells as drug vehicles to deliver drugs to targeted sites. Therapeutics or imaging agents are loaded into these cells and then released in diseased sites. These specific cells mainly include red blood cells, leukocytes, stem cells and so on. The cell acts as a Trojan horse to transfer the drug from circulating blood to the diseased tissue. In such a system, these cells keep their original properties, which allow them to mimic the migration behavior of specific cells to carry drug to the targeted site after in vivo administration. This strategy elegantly combines the advantages of both carriers, i.e. the adjustability of nanoparticles (NPs) and the natural functions of active cells, which therefore provides a new perspective to challenge current obstacles in drug delivery. This review will describe a fundamental understanding of these cell-based drug delivery systems, and discuss the great potential of combinational application of cell carrier and NPs.</description><subject>Animals</subject><subject>carrier</subject><subject>Drug Carriers</subject><subject>Drug Compounding</subject><subject>Drug delivery systems</subject><subject>Drug Delivery Systems - methods</subject><subject>Erythrocyte Transfusion</subject><subject>Erythrocytes - metabolism</subject><subject>Humans</subject><subject>leukocyte</subject><subject>Leukocyte Transfusion</subject><subject>Leukocytes - metabolism</subject><subject>Nanomedicine</subject><subject>nanoparticle</subject><subject>Nanoparticles</subject><subject>Pharmaceutical Preparations - administration & dosage</subject><subject>Pharmaceutical Preparations - chemistry</subject><subject>Pharmaceutical Preparations - metabolism</subject><subject>Red blood cell</subject><subject>Review</subject><subject>stem cell</subject><subject>Stem Cell Transplantation</subject><subject>Stem Cells - metabolism</subject><subject>Technology, Pharmaceutical - methods</subject><subject>Time Factors</subject><subject>Tissue Distribution</subject><subject>Transdermal medication</subject><issn>1071-7544</issn><issn>1521-0464</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNp9kU9vEzEQxVcIREvhI4AscU7q8Z_EywFRVUArVeICZ2vWHieONutgb9Lm2-OQtKIXTn62f_Nm7Nc074FPgRt-CXwOc63UVHCYTUFI3nL5ojkHLWDC1Uy9rLoykwN01rwpZcU5NyD06-ZMGNBaS3PexCs2pB31rIwZR1rs2ZgYumWkHTEKgdwYq_J5u2Ce-qrz_hOjh02f4sgc9X1hWJjDnCNl5tK6iwN5dh_HJRtwSBvMY3Q9lbfNq4B9oXen9aL59e3rz-ubyd2P77fXV3cTp2dinHgUrlW6VYbAKSKYE-dBe9dhMBL5zHuJqp0LHXhHXEjpdQuO170yXnl50dwefX3Cld3kuMa8twmj_XuQ8sKeRrKuJePB1GoA1aFCB23XaRdQaGXw4PX56LXZdmvyjob6S_0z0-c3Q1zaRdpZIxSAbqvBx5NBTr-3VEa7Sts81PdbAa0WUnAOldJHyuVUSqbw1AG4PaRtH9O2h7TtKe1a9-Hf8Z6qHuOtwJcjEIeQ8hrvU-69HXHfpxwyDi4WK__f4w9D67ue</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Pang, Liang</creator><creator>Zhang, Chun</creator><creator>Qin, Jing</creator><creator>Han, Limei</creator><creator>Li, Ruixiang</creator><creator>Hong, Chao</creator><creator>He, Huining</creator><creator>Wang, Jianxin</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88I</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M2P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20170101</creationdate><title>A novel strategy to achieve effective drug delivery: exploit cells as carrier combined with nanoparticles</title><author>Pang, Liang ; Zhang, Chun ; Qin, Jing ; Han, Limei ; Li, Ruixiang ; Hong, Chao ; He, Huining ; Wang, Jianxin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c562t-da2c945948e1c4ee17e00f5dcbaf83a06dd3a49725f0be0233d591c025f48d4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>carrier</topic><topic>Drug Carriers</topic><topic>Drug Compounding</topic><topic>Drug delivery systems</topic><topic>Drug Delivery Systems - methods</topic><topic>Erythrocyte Transfusion</topic><topic>Erythrocytes - metabolism</topic><topic>Humans</topic><topic>leukocyte</topic><topic>Leukocyte Transfusion</topic><topic>Leukocytes - metabolism</topic><topic>Nanomedicine</topic><topic>nanoparticle</topic><topic>Nanoparticles</topic><topic>Pharmaceutical Preparations - administration & dosage</topic><topic>Pharmaceutical Preparations - chemistry</topic><topic>Pharmaceutical Preparations - metabolism</topic><topic>Red blood cell</topic><topic>Review</topic><topic>stem cell</topic><topic>Stem Cell Transplantation</topic><topic>Stem Cells - metabolism</topic><topic>Technology, Pharmaceutical - methods</topic><topic>Time Factors</topic><topic>Tissue Distribution</topic><topic>Transdermal medication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pang, Liang</creatorcontrib><creatorcontrib>Zhang, Chun</creatorcontrib><creatorcontrib>Qin, Jing</creatorcontrib><creatorcontrib>Han, Limei</creatorcontrib><creatorcontrib>Li, Ruixiang</creatorcontrib><creatorcontrib>Hong, Chao</creatorcontrib><creatorcontrib>He, Huining</creatorcontrib><creatorcontrib>Wang, Jianxin</creatorcontrib><collection>Access via Taylor & Francis (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Drug delivery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pang, Liang</au><au>Zhang, Chun</au><au>Qin, Jing</au><au>Han, Limei</au><au>Li, Ruixiang</au><au>Hong, Chao</au><au>He, Huining</au><au>Wang, Jianxin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel strategy to achieve effective drug delivery: exploit cells as carrier combined with nanoparticles</atitle><jtitle>Drug delivery</jtitle><addtitle>Drug Deliv</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>24</volume><issue>1</issue><spage>83</spage><epage>91</epage><pages>83-91</pages><issn>1071-7544</issn><eissn>1521-0464</eissn><abstract>Cell-mediated drug delivery systems employ specific cells as drug vehicles to deliver drugs to targeted sites. Therapeutics or imaging agents are loaded into these cells and then released in diseased sites. These specific cells mainly include red blood cells, leukocytes, stem cells and so on. The cell acts as a Trojan horse to transfer the drug from circulating blood to the diseased tissue. In such a system, these cells keep their original properties, which allow them to mimic the migration behavior of specific cells to carry drug to the targeted site after in vivo administration. This strategy elegantly combines the advantages of both carriers, i.e. the adjustability of nanoparticles (NPs) and the natural functions of active cells, which therefore provides a new perspective to challenge current obstacles in drug delivery. This review will describe a fundamental understanding of these cell-based drug delivery systems, and discuss the great potential of combinational application of cell carrier and NPs.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>28155538</pmid><doi>10.1080/10717544.2016.1230903</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1071-7544 |
| ispartof | Drug delivery, 2017-01, Vol.24 (1), p.83-91 |
| issn | 1071-7544 1521-0464 |
| language | eng |
| recordid | cdi_proquest_journals_2195232001 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Access via Taylor & Francis (Open Access Collection); EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals carrier Drug Carriers Drug Compounding Drug delivery systems Drug Delivery Systems - methods Erythrocyte Transfusion Erythrocytes - metabolism Humans leukocyte Leukocyte Transfusion Leukocytes - metabolism Nanomedicine nanoparticle Nanoparticles Pharmaceutical Preparations - administration & dosage Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - metabolism Red blood cell Review stem cell Stem Cell Transplantation Stem Cells - metabolism Technology, Pharmaceutical - methods Time Factors Tissue Distribution Transdermal medication |
| title | A novel strategy to achieve effective drug delivery: exploit cells as carrier combined with nanoparticles |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T00%3A10%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20novel%20strategy%20to%20achieve%20effective%20drug%20delivery:%20exploit%20cells%20as%20carrier%20combined%20with%20nanoparticles&rft.jtitle=Drug%20delivery&rft.au=Pang,%20Liang&rft.date=2017-01-01&rft.volume=24&rft.issue=1&rft.spage=83&rft.epage=91&rft.pages=83-91&rft.issn=1071-7544&rft.eissn=1521-0464&rft_id=info:doi/10.1080/10717544.2016.1230903&rft_dat=%3Cproquest_pubme%3E2195232001%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2195232001&rft_id=info:pmid/28155538&rft_doaj_id=oai_doaj_org_article_c9e8d181c0114ba4ac19bb5cfa2548ad&rfr_iscdi=true |