Development of a modified lymphocyte transformation test for diagnosing drug-induced liver injury associated with an adaptive immune response

Drug-induced liver injury (DILI) is a growing problem. Diagnostic methods to differentiate DILI caused by an adaptive immune response from liver injury of other causes or to identify the responsible drug in patients receiving multiple drugs, herbals and/or dietary supplements (polypharmacy) have not...

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Veröffentlicht in:	Journal of immunotoxicology 2017-01, Vol.14 (1), p.31-38
Hauptverfasser:	Whritenour, Jessica, Ko, Mira, Zong, Qing, Wang, Jianying, Tartaro, Karrie, Schneider, Patricia, Olson, Ellen, Van Volkenburg, Maria, Serrano, Jose, Hayashi, Paul, Fontana, Robert, Chalasani, Naga, Bonkovsky, Herbert L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adaptive Immunity Allergic reactions Cell Proliferation Cells, Cultured Chemical and Drug Induced Liver Injury - diagnosis Chemical and Drug Induced Liver Injury - immunology Cytokines - metabolism Diagnosis, Differential Dietary supplements Drug Hypersensitivity - diagnosis Drug Hypersensitivity - immunology drug-induced liver injury drugs Feasibility Studies Follow-Up Studies Granzyme B Granzymes - metabolism Hepatitis Hepatitis - diagnosis Hepatitis - immunology Humans Hypersensitivity Immune response immuno-allergic Immunologic Tests - methods Immunosuppressive agents Isoniazid Isoniazid - adverse effects Isoniazid - therapeutic use Leukocytes (mononuclear) Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Liver Lymphocyte Activation Lymphocyte transformation lymphocyte transformation test Lymphocytes Peripheral blood mononuclear cells Thymidine
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