PI3K/Akt and Nrf2/HO-1 pathways involved in the hepatoprotective effect of verapamil against thioacetamide toxicity in rats

Liver is a precious organ to maintain body life. Hepatotoxicity is a worldwide health problem that is still a challenge for research. Although countless pharmaceutical drugs and herbal compounds were screened for their hepatoprotective effects, the death from hepatotoxicity is increasing. Thus, ther...

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Veröffentlicht in:	Human & experimental toxicology 2019-04, Vol.38 (4), p.381-388
Hauptverfasser:	Mohamed, MZ, Hafez, HM, Hassan, M, Ibrahim, MA
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Antihypertensives Antioxidants Antioxidants - pharmacology Antioxidants - therapeutic use Calcium Calcium channel blockers Calcium Channel Blockers - pharmacology Calcium Channel Blockers - therapeutic use Chemical and Drug Induced Liver Injury - drug therapy Chemical and Drug Induced Liver Injury - genetics Chemical and Drug Induced Liver Injury - pathology Drugs Gene expression Heme Heme oxygenase (decyclizing) Heme Oxygenase (Decyclizing) - genetics Hepatotoxicity Inflammation Kinases Lipid peroxidation Lipids Liver Liver - drug effects Liver - metabolism Liver - pathology Male NF-E2-Related Factor 2 - genetics Oxygenase Peroxidation Phosphatidylinositol 3-Kinases - genetics Protein kinase Proteins Proto-Oncogene Proteins c-akt - genetics Rats Rodents Searching Signal Transduction Thioacetamide Threonine Toxicity Verapamil Verapamil - pharmacology Verapamil - therapeutic use
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