Formulation and evaluation of immediate release tablet of risperidone

Risperidone immediate tablets were prepared by directs compression technique as per the formula given in the Table 1 The superdisintegrants such as kollidon and citric acid were used in different proportions2'3 Procedure: All the ingredients were passed through sieve #40 and were subjected for drying to remove moisture content . Experimental Data: Preparation of hydrochloric acid (0.1N) solution: A volume of 8.5 ml of concentration HCL was accurately measured using 10ml pipette and transferred into clean 100ml volumetric flask diluted with water solution prepared and shaken thoroughly Preparation of risperdione standard stock solution with (0.1N )Hcl solution: The absorbance of each solution was measured at 236nm using UV spectrophotometer photometric mode.6-8 Calibration curve of Risperidone in 0.1 N hydrochloric acid solution: [...]it should follow first order kinetics profile, if it claims to release the drug initially very quickly.