Effects of carbon dioxide pneumoperitoneum on hemodynamics in cirrhotic rats
The aim of our study was to investigate the effect of carbon dioxide pneumoperitoneum on systemic and splanchnic hemodynamics in cirrhotic rats. Sprague-Dawley rats (n = 80) were used in this study. Liver cirrhosis was induced by thioacetamide administration intraperitoneally (200 mg/kg body weight,...
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| Veröffentlicht in: | Surgical endoscopy 2002-08, Vol.16 (8), p.1220-1225 |
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| creator | TSUBOI, S KITANO, S YOSHIDA, T BANDOH, T NINOMIYA, K BAATAR, D |
| description | The aim of our study was to investigate the effect of carbon dioxide pneumoperitoneum on systemic and splanchnic hemodynamics in cirrhotic rats.
Sprague-Dawley rats (n = 80) were used in this study. Liver cirrhosis was induced by thioacetamide administration intraperitoneally (200 mg/kg body weight, twice a week for 16 weeks). The radioactive microsphere method was used to measure systemic and regional hemodynamic parameters before, 1 h after the start, and 1 h after the release of pneumoperitoneum.
Splanchnic blood flow and cardiac index were significantly depressed during pneumoperitoneum in liver cirrhosis and control groups, but no significant differences were seen between the two groups. In both groups, portal venous inflow decreased and hepatic arterial blood flow increased significantly during pneumoperitoneum. However, during pneumoperitoneum, total hepatic blood flow as a percentage of its value before pneumoperitoneum was lower in cirrhotic rats (71.0%) than in control rats (91.9%) (p |
| doi_str_mv | 10.1007/s00464-001-9163-x |
| format | Article |
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Sprague-Dawley rats (n = 80) were used in this study. Liver cirrhosis was induced by thioacetamide administration intraperitoneally (200 mg/kg body weight, twice a week for 16 weeks). The radioactive microsphere method was used to measure systemic and regional hemodynamic parameters before, 1 h after the start, and 1 h after the release of pneumoperitoneum.
Splanchnic blood flow and cardiac index were significantly depressed during pneumoperitoneum in liver cirrhosis and control groups, but no significant differences were seen between the two groups. In both groups, portal venous inflow decreased and hepatic arterial blood flow increased significantly during pneumoperitoneum. However, during pneumoperitoneum, total hepatic blood flow as a percentage of its value before pneumoperitoneum was lower in cirrhotic rats (71.0%) than in control rats (91.9%) (p <0.05, Mann-Whitney U-test).
Carbon dioxide pneumoperitoneum markedly decreases total hepatic blood flow in cirrhotic rats due to the impaired hepatic arterial buffer response. Liver function should be carefully controlled in cirrhotic patients after laparoscopic surgery with pneumoperitoneum.</description><identifier>ISSN: 0930-2794</identifier><identifier>EISSN: 1432-2218</identifier><identifier>DOI: 10.1007/s00464-001-9163-x</identifier><identifier>PMID: 11984669</identifier><identifier>CODEN: SUREEX</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>Animals ; Biological and medical sciences ; Blood Pressure ; Carbon Dioxide ; Catheters ; Gastroenterology. Liver. Pancreas. Abdomen ; Heart Rate ; Hemodynamics ; Laparoscopy ; Laparoscopy - adverse effects ; Liver - blood supply ; Liver cirrhosis ; Liver Cirrhosis - chemically induced ; Liver Cirrhosis - physiopathology ; Liver Cirrhosis - therapy ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Ostomy ; Other diseases. Semiology ; Pneumoperitoneum, Artificial - adverse effects ; Portal Vein - physiopathology ; Rats ; Rats, Inbred Strains ; Rats, Sprague-Dawley ; Regional Blood Flow ; Splanchnic Circulation ; Surgery ; Thioacetamide ; Veins & arteries</subject><ispartof>Surgical endoscopy, 2002-08, Vol.16 (8), p.1220-1225</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright Springer-Verlag 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-4dcd561f48c6214e376279a7f5721cb9dcee0a5118187e8ae73a895e13d329fc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14026403$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11984669$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TSUBOI, S</creatorcontrib><creatorcontrib>KITANO, S</creatorcontrib><creatorcontrib>YOSHIDA, T</creatorcontrib><creatorcontrib>BANDOH, T</creatorcontrib><creatorcontrib>NINOMIYA, K</creatorcontrib><creatorcontrib>BAATAR, D</creatorcontrib><title>Effects of carbon dioxide pneumoperitoneum on hemodynamics in cirrhotic rats</title><title>Surgical endoscopy</title><addtitle>Surg Endosc</addtitle><description>The aim of our study was to investigate the effect of carbon dioxide pneumoperitoneum on systemic and splanchnic hemodynamics in cirrhotic rats.
Sprague-Dawley rats (n = 80) were used in this study. Liver cirrhosis was induced by thioacetamide administration intraperitoneally (200 mg/kg body weight, twice a week for 16 weeks). The radioactive microsphere method was used to measure systemic and regional hemodynamic parameters before, 1 h after the start, and 1 h after the release of pneumoperitoneum.
Splanchnic blood flow and cardiac index were significantly depressed during pneumoperitoneum in liver cirrhosis and control groups, but no significant differences were seen between the two groups. In both groups, portal venous inflow decreased and hepatic arterial blood flow increased significantly during pneumoperitoneum. However, during pneumoperitoneum, total hepatic blood flow as a percentage of its value before pneumoperitoneum was lower in cirrhotic rats (71.0%) than in control rats (91.9%) (p <0.05, Mann-Whitney U-test).
Carbon dioxide pneumoperitoneum markedly decreases total hepatic blood flow in cirrhotic rats due to the impaired hepatic arterial buffer response. Liver function should be carefully controlled in cirrhotic patients after laparoscopic surgery with pneumoperitoneum.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Carbon Dioxide</subject><subject>Catheters</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Heart Rate</subject><subject>Hemodynamics</subject><subject>Laparoscopy</subject><subject>Laparoscopy - adverse effects</subject><subject>Liver - blood supply</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - chemically induced</subject><subject>Liver Cirrhosis - physiopathology</subject><subject>Liver Cirrhosis - therapy</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Ostomy</subject><subject>Other diseases. Semiology</subject><subject>Pneumoperitoneum, Artificial - adverse effects</subject><subject>Portal Vein - physiopathology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Rats, Sprague-Dawley</subject><subject>Regional Blood Flow</subject><subject>Splanchnic Circulation</subject><subject>Surgery</subject><subject>Thioacetamide</subject><subject>Veins & arteries</subject><issn>0930-2794</issn><issn>1432-2218</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpFkE1LAzEQhoMotlZ_gBdZBI-rmSSb3Ryl1A8oeNFzSPNBU7qbNdmF9t-b0gVPMzDPOzM8CN0DfgaM65eEMeOsxBhKAZyWhws0B0ZJSQg0l2iOBcUlqQWboZuUdjjjAqprNAMQDeNczNF65ZzVQyqCK7SKm9AVxoeDN7boOzu2obfRD-HUFnm2tW0wx061XqfCd4X2MW7D4HUR1ZBu0ZVT-2TvprpAP2-r7-VHuf56_1y-rkvNmBhKZrSpODjWaE6AWVrz_KSqXVUT0BthtLVYVQANNLVtlK2pakRlgRpKhNN0gR7Pe_sYfkebBrkLY-zySUlAMMoZNBmCM6RjSClaJ_voWxWPErA86ZNnfTLrkyd98pAzD9PicdNa85-YfGXgaQJU0mrvouq0T_8cw4QzTOkfLmB4Mg</recordid><startdate>20020801</startdate><enddate>20020801</enddate><creator>TSUBOI, S</creator><creator>KITANO, S</creator><creator>YOSHIDA, T</creator><creator>BANDOH, T</creator><creator>NINOMIYA, K</creator><creator>BAATAR, D</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20020801</creationdate><title>Effects of carbon dioxide pneumoperitoneum on hemodynamics in cirrhotic rats</title><author>TSUBOI, S ; KITANO, S ; YOSHIDA, T ; BANDOH, T ; NINOMIYA, K ; BAATAR, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-4dcd561f48c6214e376279a7f5721cb9dcee0a5118187e8ae73a895e13d329fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Carbon Dioxide</topic><topic>Catheters</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Heart Rate</topic><topic>Hemodynamics</topic><topic>Laparoscopy</topic><topic>Laparoscopy - adverse effects</topic><topic>Liver - blood supply</topic><topic>Liver cirrhosis</topic><topic>Liver Cirrhosis - chemically induced</topic><topic>Liver Cirrhosis - physiopathology</topic><topic>Liver Cirrhosis - therapy</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Ostomy</topic><topic>Other diseases. Semiology</topic><topic>Pneumoperitoneum, Artificial - adverse effects</topic><topic>Portal Vein - physiopathology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Rats, Sprague-Dawley</topic><topic>Regional Blood Flow</topic><topic>Splanchnic Circulation</topic><topic>Surgery</topic><topic>Thioacetamide</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TSUBOI, S</creatorcontrib><creatorcontrib>KITANO, S</creatorcontrib><creatorcontrib>YOSHIDA, T</creatorcontrib><creatorcontrib>BANDOH, T</creatorcontrib><creatorcontrib>NINOMIYA, K</creatorcontrib><creatorcontrib>BAATAR, D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Surgical endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TSUBOI, S</au><au>KITANO, S</au><au>YOSHIDA, T</au><au>BANDOH, T</au><au>NINOMIYA, K</au><au>BAATAR, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of carbon dioxide pneumoperitoneum on hemodynamics in cirrhotic rats</atitle><jtitle>Surgical endoscopy</jtitle><addtitle>Surg Endosc</addtitle><date>2002-08-01</date><risdate>2002</risdate><volume>16</volume><issue>8</issue><spage>1220</spage><epage>1225</epage><pages>1220-1225</pages><issn>0930-2794</issn><eissn>1432-2218</eissn><coden>SUREEX</coden><abstract>The aim of our study was to investigate the effect of carbon dioxide pneumoperitoneum on systemic and splanchnic hemodynamics in cirrhotic rats.
Sprague-Dawley rats (n = 80) were used in this study. Liver cirrhosis was induced by thioacetamide administration intraperitoneally (200 mg/kg body weight, twice a week for 16 weeks). The radioactive microsphere method was used to measure systemic and regional hemodynamic parameters before, 1 h after the start, and 1 h after the release of pneumoperitoneum.
Splanchnic blood flow and cardiac index were significantly depressed during pneumoperitoneum in liver cirrhosis and control groups, but no significant differences were seen between the two groups. In both groups, portal venous inflow decreased and hepatic arterial blood flow increased significantly during pneumoperitoneum. However, during pneumoperitoneum, total hepatic blood flow as a percentage of its value before pneumoperitoneum was lower in cirrhotic rats (71.0%) than in control rats (91.9%) (p <0.05, Mann-Whitney U-test).
Carbon dioxide pneumoperitoneum markedly decreases total hepatic blood flow in cirrhotic rats due to the impaired hepatic arterial buffer response. Liver function should be carefully controlled in cirrhotic patients after laparoscopic surgery with pneumoperitoneum.</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>11984669</pmid><doi>10.1007/s00464-001-9163-x</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Blood Pressure Carbon Dioxide Catheters Gastroenterology. Liver. Pancreas. Abdomen Heart Rate Hemodynamics Laparoscopy Laparoscopy - adverse effects Liver - blood supply Liver cirrhosis Liver Cirrhosis - chemically induced Liver Cirrhosis - physiopathology Liver Cirrhosis - therapy Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Ostomy Other diseases. Semiology Pneumoperitoneum, Artificial - adverse effects Portal Vein - physiopathology Rats Rats, Inbred Strains Rats, Sprague-Dawley Regional Blood Flow Splanchnic Circulation Surgery Thioacetamide Veins & arteries |
| title | Effects of carbon dioxide pneumoperitoneum on hemodynamics in cirrhotic rats |
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