Levels of uric acid in erectile dysfunction of different aetiology
Erectile dysfunction is a common disease characterized by endothelial dysfunction. The aetiology of ED is often multifactorial but evidence is being accumulated in favor of the proper function of the vascular endothelium that is essential to achieving and maintaining penile erection. Uric acid itsel...
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| Veröffentlicht in: | The aging male 2018-07, Vol.21 (3), p.200-205 |
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| creator | Barassi, Alessandra Corsi Romanelli, Massimiliano Marco Pezzilli, Raffaele Dozio, Elena Damele, Clara Anna Linda Vaccalluzzo, Liborio Di Dario, Marco Goi, Giancarlo Papini, Nadia Massaccesi, Luca Colpi, Giovanni Maria Melzi d'Eril, Gian Vico |
| description | Erectile dysfunction is a common disease characterized by endothelial dysfunction. The aetiology of ED is often multifactorial but evidence is being accumulated in favor of the proper function of the vascular endothelium that is essential to achieving and maintaining penile erection. Uric acid itself causes endothelial dysfunction via decreased nitric oxide production. This study aims to evaluate the serum uric acid (SUA) levels in 180 ED patients, diagnosed with the International Index of Erectile Function-5 (IIEF-5) and 30 non-ED control. Serum uric acid was analyzed with a commercially available kit using ModularEVO (Roche, Monza, Italy). Within-assay and between-assay variations were 3.0% and 6.0%, respectively. Out of the ED patients, 85 were classified as arteriogenic (A-ED) and 95 as non-arteriogenic (NA-ED) with penile-echo-color-Doppler. Uric acid levels (median and range in mg/dL) in A-ED patients (5.8, 4.3-7.5) were significantly higher (p |
| doi_str_mv | 10.1080/13685538.2017.1420158 |
| format | Article |
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The aetiology of ED is often multifactorial but evidence is being accumulated in favor of the proper function of the vascular endothelium that is essential to achieving and maintaining penile erection. Uric acid itself causes endothelial dysfunction via decreased nitric oxide production. This study aims to evaluate the serum uric acid (SUA) levels in 180 ED patients, diagnosed with the International Index of Erectile Function-5 (IIEF-5) and 30 non-ED control. Serum uric acid was analyzed with a commercially available kit using ModularEVO (Roche, Monza, Italy). Within-assay and between-assay variations were 3.0% and 6.0%, respectively. Out of the ED patients, 85 were classified as arteriogenic (A-ED) and 95 as non-arteriogenic (NA-ED) with penile-echo-color-Doppler. Uric acid levels (median and range in mg/dL) in A-ED patients (5.8, 4.3-7.5) were significantly higher (p < .001) than in NA-ED patients (4.4, 2.6-5.9) and in control group (4.6, 3.1-7.2). There was a significant difference (p < .001) between uric acid levels in patients with mild A-ED (IIEF-5 16-20) and severe/complete A-ED (IIEF-5 ≤ 10) that were 5.4 (range 4.3-6.5) mg/dL and 6.8 (range 6.4-7.2) mg/dL, respectively. There was no difference between the levels of uric acid in patients with different degree of NA-ED. Our findings reveal that SUA is a marker of ED but only of ED of arteriogenic aetiology.</description><identifier>ISSN: 1368-5538</identifier><identifier>EISSN: 1473-0790</identifier><identifier>DOI: 10.1080/13685538.2017.1420158</identifier><identifier>PMID: 29327639</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>aging and uric acid ; Endothelial dysfunction ; Erectile dysfunction ; Etiology ; Kidney stones ; Mens health ; Older people ; Reproductive system ; Sexual disorders ; Uric acid</subject><ispartof>The aging male, 2018-07, Vol.21 (3), p.200-205</ispartof><rights>2018 Informa UK Limited, trading as Taylor & Francis Group 2018</rights><rights>2018 Informa UK Limited, trading as Taylor & Francis Group</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-f00c8bc2c6fa58d397e3650f6ad3c94193c0358a129cb26655449a68f615c5b73</citedby><cites>FETCH-LOGICAL-c394t-f00c8bc2c6fa58d397e3650f6ad3c94193c0358a129cb26655449a68f615c5b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29327639$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barassi, Alessandra</creatorcontrib><creatorcontrib>Corsi Romanelli, Massimiliano Marco</creatorcontrib><creatorcontrib>Pezzilli, Raffaele</creatorcontrib><creatorcontrib>Dozio, Elena</creatorcontrib><creatorcontrib>Damele, Clara Anna Linda</creatorcontrib><creatorcontrib>Vaccalluzzo, Liborio</creatorcontrib><creatorcontrib>Di Dario, Marco</creatorcontrib><creatorcontrib>Goi, Giancarlo</creatorcontrib><creatorcontrib>Papini, Nadia</creatorcontrib><creatorcontrib>Massaccesi, Luca</creatorcontrib><creatorcontrib>Colpi, Giovanni Maria</creatorcontrib><creatorcontrib>Melzi d'Eril, Gian Vico</creatorcontrib><title>Levels of uric acid in erectile dysfunction of different aetiology</title><title>The aging male</title><addtitle>Aging Male</addtitle><description>Erectile dysfunction is a common disease characterized by endothelial dysfunction. The aetiology of ED is often multifactorial but evidence is being accumulated in favor of the proper function of the vascular endothelium that is essential to achieving and maintaining penile erection. Uric acid itself causes endothelial dysfunction via decreased nitric oxide production. This study aims to evaluate the serum uric acid (SUA) levels in 180 ED patients, diagnosed with the International Index of Erectile Function-5 (IIEF-5) and 30 non-ED control. Serum uric acid was analyzed with a commercially available kit using ModularEVO (Roche, Monza, Italy). Within-assay and between-assay variations were 3.0% and 6.0%, respectively. Out of the ED patients, 85 were classified as arteriogenic (A-ED) and 95 as non-arteriogenic (NA-ED) with penile-echo-color-Doppler. Uric acid levels (median and range in mg/dL) in A-ED patients (5.8, 4.3-7.5) were significantly higher (p < .001) than in NA-ED patients (4.4, 2.6-5.9) and in control group (4.6, 3.1-7.2). There was a significant difference (p < .001) between uric acid levels in patients with mild A-ED (IIEF-5 16-20) and severe/complete A-ED (IIEF-5 ≤ 10) that were 5.4 (range 4.3-6.5) mg/dL and 6.8 (range 6.4-7.2) mg/dL, respectively. There was no difference between the levels of uric acid in patients with different degree of NA-ED. Our findings reveal that SUA is a marker of ED but only of ED of arteriogenic aetiology.</description><subject>aging and uric acid</subject><subject>Endothelial dysfunction</subject><subject>Erectile dysfunction</subject><subject>Etiology</subject><subject>Kidney stones</subject><subject>Mens health</subject><subject>Older people</subject><subject>Reproductive system</subject><subject>Sexual disorders</subject><subject>Uric acid</subject><issn>1368-5538</issn><issn>1473-0790</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLAzEQgIMoVqs_QVnw4mVr3o-bWnxBwYueQ5pNJGW7qcmu0n9vSlsPHjzNMPPNgw-ACwQnCEp4gwiXjBE5wRCJCaIlMHkAThAVpIZCwcOSF6beQCNwmvMCQoSFEMdghBXBghN1Au5n7su1uYq-GlKwlbGhqUJXueRsH1pXNevsh67ksdtATfC-9Lq-Mq7U2vixPgNH3rTZne_iGLw_PrxNn-vZ69PL9G5WW6JoX3sIrZxbbLk3TDZECUc4g56bhlhFkSIWEiYNwsrOMeeMUaoMl54jZtlckDG43u5dpfg5uNzrZcjWta3pXByyRkoqDjHFvKBXf9BFHFJXvtMYKQoxoxgVim0pm2LOyXm9SmFp0lojqDeS9V6y3kjWO8ll7nK3fZgvXfM7tbdagNstEDof09J8x9Q2ujfrNiafTGdD1uT_Gz_roolp</recordid><startdate>20180703</startdate><enddate>20180703</enddate><creator>Barassi, Alessandra</creator><creator>Corsi Romanelli, Massimiliano Marco</creator><creator>Pezzilli, Raffaele</creator><creator>Dozio, Elena</creator><creator>Damele, Clara Anna Linda</creator><creator>Vaccalluzzo, Liborio</creator><creator>Di Dario, Marco</creator><creator>Goi, Giancarlo</creator><creator>Papini, Nadia</creator><creator>Massaccesi, Luca</creator><creator>Colpi, Giovanni Maria</creator><creator>Melzi d'Eril, Gian Vico</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20180703</creationdate><title>Levels of uric acid in erectile dysfunction of different aetiology</title><author>Barassi, Alessandra ; Corsi Romanelli, Massimiliano Marco ; Pezzilli, Raffaele ; Dozio, Elena ; Damele, Clara Anna Linda ; Vaccalluzzo, Liborio ; Di Dario, Marco ; Goi, Giancarlo ; Papini, Nadia ; Massaccesi, Luca ; Colpi, Giovanni Maria ; Melzi d'Eril, Gian Vico</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-f00c8bc2c6fa58d397e3650f6ad3c94193c0358a129cb26655449a68f615c5b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>aging and uric acid</topic><topic>Endothelial dysfunction</topic><topic>Erectile dysfunction</topic><topic>Etiology</topic><topic>Kidney stones</topic><topic>Mens health</topic><topic>Older people</topic><topic>Reproductive system</topic><topic>Sexual disorders</topic><topic>Uric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barassi, Alessandra</creatorcontrib><creatorcontrib>Corsi Romanelli, Massimiliano Marco</creatorcontrib><creatorcontrib>Pezzilli, Raffaele</creatorcontrib><creatorcontrib>Dozio, Elena</creatorcontrib><creatorcontrib>Damele, Clara Anna Linda</creatorcontrib><creatorcontrib>Vaccalluzzo, Liborio</creatorcontrib><creatorcontrib>Di Dario, Marco</creatorcontrib><creatorcontrib>Goi, Giancarlo</creatorcontrib><creatorcontrib>Papini, Nadia</creatorcontrib><creatorcontrib>Massaccesi, Luca</creatorcontrib><creatorcontrib>Colpi, Giovanni Maria</creatorcontrib><creatorcontrib>Melzi d'Eril, Gian Vico</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The aging male</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barassi, Alessandra</au><au>Corsi Romanelli, Massimiliano Marco</au><au>Pezzilli, Raffaele</au><au>Dozio, Elena</au><au>Damele, Clara Anna Linda</au><au>Vaccalluzzo, Liborio</au><au>Di Dario, Marco</au><au>Goi, Giancarlo</au><au>Papini, Nadia</au><au>Massaccesi, Luca</au><au>Colpi, Giovanni Maria</au><au>Melzi d'Eril, Gian Vico</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Levels of uric acid in erectile dysfunction of different aetiology</atitle><jtitle>The aging male</jtitle><addtitle>Aging Male</addtitle><date>2018-07-03</date><risdate>2018</risdate><volume>21</volume><issue>3</issue><spage>200</spage><epage>205</epage><pages>200-205</pages><issn>1368-5538</issn><eissn>1473-0790</eissn><abstract>Erectile dysfunction is a common disease characterized by endothelial dysfunction. The aetiology of ED is often multifactorial but evidence is being accumulated in favor of the proper function of the vascular endothelium that is essential to achieving and maintaining penile erection. Uric acid itself causes endothelial dysfunction via decreased nitric oxide production. This study aims to evaluate the serum uric acid (SUA) levels in 180 ED patients, diagnosed with the International Index of Erectile Function-5 (IIEF-5) and 30 non-ED control. Serum uric acid was analyzed with a commercially available kit using ModularEVO (Roche, Monza, Italy). Within-assay and between-assay variations were 3.0% and 6.0%, respectively. Out of the ED patients, 85 were classified as arteriogenic (A-ED) and 95 as non-arteriogenic (NA-ED) with penile-echo-color-Doppler. Uric acid levels (median and range in mg/dL) in A-ED patients (5.8, 4.3-7.5) were significantly higher (p < .001) than in NA-ED patients (4.4, 2.6-5.9) and in control group (4.6, 3.1-7.2). There was a significant difference (p < .001) between uric acid levels in patients with mild A-ED (IIEF-5 16-20) and severe/complete A-ED (IIEF-5 ≤ 10) that were 5.4 (range 4.3-6.5) mg/dL and 6.8 (range 6.4-7.2) mg/dL, respectively. There was no difference between the levels of uric acid in patients with different degree of NA-ED. Our findings reveal that SUA is a marker of ED but only of ED of arteriogenic aetiology.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>29327639</pmid><doi>10.1080/13685538.2017.1420158</doi><tpages>6</tpages></addata></record> |
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| subjects | aging and uric acid Endothelial dysfunction Erectile dysfunction Etiology Kidney stones Mens health Older people Reproductive system Sexual disorders Uric acid |
| title | Levels of uric acid in erectile dysfunction of different aetiology |
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