Kemp Eliminases of the AlleyCat Family Possess High Substrate Promiscuity

The front cover artwork for Issue 05/2019 is provided by the Korendoych and the Makhlynets Labs at Syracuse University (USA) in collaboration with the VIB Centre for Structural Biology (Belgium), College of Charleston (USA) and Kyiv National University (Ukraine). The image shows AlleyCat2, a minimalist allosterically regulated Kemp eliminase, efficiently promoting ring opening of leflunomide, an immunosuppresant. Small libraries of designed catalysts provide fertile ground for discovering new reactivities. See the Communication itself at https://doi.org/10.1002/cctc.201801994. “ CATalysts are wonderfull! ” This and more about the story behind the research featured on the front cover can be found in this issue's Cover Profile. Read the full text of the corresponding research at https://doi.org/10.1002/cctc.201801994.