Critical role of oxidative stress and sustained JNK activation in aloe-emodin-mediated apoptotic cell death in human hepatoma cells

Aloe-emodin (AE), one of the main bioactive anthraquinones of Rheum palmatum, possesses potent antitumor properties. Our previous proteomic study revealed that AE-induced apoptosis was associated with oxidative stress and oxidation of many redox-sensitive proteins. In this study, we aimed to further...

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Veröffentlicht in:	Carcinogenesis (New York) 2007-09, Vol.28 (9), p.1937-1945
Hauptverfasser:	Lu, Guo Dong, Shen, Han-Ming, Chung, Maxey C.M., Ong, Choon Nam
Format:	Artikel
Sprache:	eng
Schlagworte:	Aloe Apoptosis - drug effects Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carcinoma, Hepatocellular - pathology Cell Death - drug effects Cell Line, Tumor Emodin - pharmacology Gastroenterology. Liver. Pancreas. Abdomen Glutathione - metabolism Glutathione Disulfide - metabolism Humans Liver Neoplasms - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Mitogen-Activated Protein Kinase Kinases - metabolism Oxidative Stress - drug effects Plant Extracts - pharmacology Tumors
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