Development and molecular characterization of HCT-116 cell lines resistant to the tumor promoter and multiple stress-inducer, deoxycholate

Evidence from live cell bioassays shows that the flat mucosa from patients with colon cancer exhibits resistance to bile salt-induced apoptosis. Three independent cell lines derived from the colonic epithelial cell line HCT-116 were selected for resistance to bile salt-induced apoptosis. These cell...

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Veröffentlicht in:	Carcinogenesis (New York) 2002-12, Vol.23 (12), p.2063-2080
Hauptverfasser:	Crowley-Weber, Cara L., Payne, Claire M., Gleason-Guzman, Mary, Watts, George S., Futscher, Bernard, Waltmire, Caroline N., Crowley, Cheray, Dvorakova, Katerina, Bernstein, Carol, Craven, Mary, Garewal, Harinder, Bernstein, Harris
Format:	Artikel
Sprache:	eng
Schlagworte:	78 kD-glucose-regulated protein Apoptosis Bcl2/adenovirus EIB 19 kD-interacting protein 3 BH4 Biological and medical sciences BNIP3 calcium/calmodulin-dependent protein kinase II delta CAMK2D Carcinogenesis, carcinogens and anticarcinogens Carrier Proteins - metabolism cGMP-activated protein kinase Chemical agents Colon - metabolism deoxycholate Deoxycholic Acid - pharmacology Detergents - pharmacology DHAP dihydroxyacetone phosphate DNA, Complementary - metabolism DOC Down-Regulation Drug Resistance, Neoplasm EGFR Electrophoresis, Gel, Two-Dimensional endoplasmic reticulum epidermal growth factor receptor Epithelial Cells GAP glyceraldehyde 3-phosphate Grp78 guanylate cyclase Heat-Shock Proteins Humans IAP IEF IKK-β inducible NO synthase inhibitor of apoptosis protein inositol triphosphate IP3 isoelectric focusing IκB-kinase-β Lysosomes - metabolism MALDI-MS MAPK MAPK kinase matrix assisted laser desorption ionization mass spectroscopy Medical sciences MEK MEK kinase MEKK Microscopy, Confocal Microscopy, Electron Microscopy, Fluorescence Mitochondria - metabolism mitogen-activated protein kinase Models, Biological Molecular Chaperones - metabolism NaDOC NF-kappa B - metabolism NF-kappa B p50 Subunit NF-κB-inducing kinase NIK nitric oxide NLS NOS2 nuclear localization signal Oligonucleotide Array Sequence Analysis Oligonucleotides - pharmacology Oligonucleotides, Antisense - pharmacology ONOO Oxidative Stress PDTC peroxynitrite PKCζ PKG PN-1 Promoter Regions, Genetic protease nexin-1 protein kinase C-zeta Proto-Oncogene Proteins c-bcl-2 - metabolism pyrrolidine dithiocarbamate QDPR quinoid dihydropteridine reductase Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism serine protease inhibitor SERPIN sodium deoxycholate Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization TEM tetrahydrobiopterin thenoyl trifluoroacetone thioredoxin TPI TPx TRAF Transcription Factor RelA transmission electron microscopy triose phosphate isomerase Trx Trx peroxidase (peroxiredoxin) Trx reductase TTFA Tumor Cells, Cultured tumor necrosis factor receptor-associated factor Tumors Up-Regulation
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