Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells

Malignant pleural mesothelioma (MPM) is an aggressive neoplasm associated with asbestos exposure. Although expression and activation of receptor tyrosine kinases (RTKs), including MET, have been reported in most MPM, specific RTK inhibitors showed less than the expected response in MPM cells. To det...

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Veröffentlicht in:	Carcinogenesis (New York) 2009-07, Vol.30 (7), p.1097-1105
Hauptverfasser:	Kawaguchi, Koji, Murakami, Hideki, Taniguchi, Tetsuo, Fujii, Makiko, Kawata, Shigehisa, Fukui, Takayuki, Kondo, Yutaka, Osada, Hirotaka, Usami, Noriyasu, Yokoi, Kohei, Ueda, Yuichi, Yatabe, Yasushi, Ito, Masafumi, Horio, Yoshitsugu, Hida, Toyoaki, Sekido, Yoshitaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Cell Line, Tumor Cell Proliferation - drug effects Humans Medical sciences Mesothelioma - metabolism Mesothelioma - pathology Neoplasm Invasiveness Phosphorylation Pleural Neoplasms - metabolism Pleural Neoplasms - pathology Proto-Oncogene Proteins c-met - antagonists & inhibitors Proto-Oncogene Proteins c-met - metabolism Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - metabolism Receptor, ErbB-2 - antagonists & inhibitors Receptor, ErbB-2 - metabolism Receptor, Platelet-Derived Growth Factor beta - antagonists & inhibitors Receptor, Platelet-Derived Growth Factor beta - metabolism Signal Transduction - drug effects Signal Transduction - physiology Tumors Up-Regulation
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