SULT1A1 catalyzes 2-methoxyestradiol sulfonation in MCF-7 breast cancer cells

In a previous study of nine human breast-derived cell lines, rates of metabolism of 17β-estradiol (E2) were greatly enhanced when cultures were exposed to the aromatic hydrocarbon receptor agonist, 2,3,7,8-tetrachlorodibenzo-p-dioxin. Elevated rates of E2 hydroxylation at the C-2, -4, -6α and -15α p...

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Veröffentlicht in:	Carcinogenesis (New York) 2000-11, Vol.21 (11), p.1947-1957
Hauptverfasser:	Spink, Barbara C., Katz, Barbara H., Hussain, Mirza M., Pang, Shaokun, Connor, Steven P., Aldous, Kenneth M., Gierthy, John F., Spink, David C.
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-estradiol 2-MeOE2-3S 2-Methoxyestradiol 2-methoxyestradiol-3-sulfate 4-lactone 8-tetrachlorodibenzo-p-dioxin Animals Arylsulfotransferase Baculoviridae - genetics Biological and medical sciences Breast - enzymology Breast - metabolism Breast Neoplasms - enzymology Breast Neoplasms - metabolism Catalysis Cell metabolism, cell oxidation Cell physiology Cells, Cultured Cloning, Molecular CYP cytochrome P450 cytosolic sulfotransferase d-saccharic acid 1 DNA, Complementary - genetics DNA, Complementary - metabolism Epithelial Cells - enzymology Epithelial Cells - metabolism Estradiol - analogs & derivatives Estradiol - metabolism estrogen receptor estrone Fundamental and applied biological sciences. Psychology G/S GAPDH gas chromatography Gene Amplification glyceraldehyde-3-phosphate dehydrogenase Gynecology. Andrology. Obstetrics Humans hydroxyestradiol Isoenzymes - biosynthesis Isoenzymes - genetics Isoenzymes - metabolism Kinetics Mammary gland diseases mass spectrometry Medical sciences MeOE1 MeOE2 methoxyestradiol methoxyestrone Molecular and cellular biology OHE2 Reverse Transcriptase Polymerase Chain Reaction reverse transcription–polymerase chain reaction RNA, Messenger - biosynthesis RNA, Messenger - genetics RT–PCR SAL Spodoptera - enzymology Spodoptera - virology Sulfates - metabolism Sulfotransferases - biosynthesis Sulfotransferases - genetics Sulfotransferases - metabolism SULT TCDD Tumor Cells, Cultured Tumors β-glucuronidase/sulfatase
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