Interactions between sulforaphane and apigenin in the induction of UGT1A1 and GSTA1 in CaCo-2 cells

The isothiocyanate, sulforaphane and the flavonoid, apigenin modulate gene expression including phase II detoxifying enzymes, such as glutathione S-transferases (GST) and UDP-glucuronosyltransferases (UGT). Using undifferentiated CaCo-2 cells, we have examined the interactions between sulforaphane a...

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Veröffentlicht in:	Carcinogenesis (New York) 2004-09, Vol.25 (9), p.1629-1637
Hauptverfasser:	Švehlíková, Vanda, Wang, Shuran, Jakubíková, Jana, Williamson, Gary, Mithen, Richard, Bao, Yongping
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - enzymology Adenocarcinoma - genetics Anticarcinogenic Agents - pharmacology antioxidant responsive element Apigenin ARE Bacterial Proteins Biological and medical sciences Caco-2 Cells Carcinogenesis, carcinogens and anticarcinogens Carrier Proteins - metabolism Chemical agents Colonic Neoplasms - enzymology Colonic Neoplasms - genetics dimethyl sulfoxide DMSO Drug Interactions Drug Synergism Enzyme Inhibitors - pharmacology ERK extracellular signal-regulated kinase Flavonoids - pharmacology Glucuronosyltransferase - metabolism glutathione S-transferase Glutathione Transferase GST Humans Intracellular Signaling Peptides and Proteins Isothiocyanates ITCs MAPK MAPK/extracellular signal-regulated kinase kinase Medical sciences MEK1 mitogen-activated protein kinase Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors NF-E2-related factor 2 NF-kappa B - metabolism NF-κB Nrf2 nuclear factor kappa B phosphatidylinositol 3-kinase Phosphatidylinositol 3-Kinases - metabolism PI3-kinase reverse transcription polymerase chain reaction RT–PCR SFN Signal Transduction SP1 Sp1 Transcription Factor - metabolism special protein 1 sulforaphane Thiocyanates - pharmacology Transcription, Genetic - drug effects Tumor Cells, Cultured Tumors UDP-glucuronosyltransferase UGT
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