Catalytic properties of polymorphic human cytochrome P450 1B1 variants

Four polymorphic human cytochrome P450 (CYP) 1B1 allelic variants, namely Arg48,Ala119,Leu432,Asn453, Arg48,Ser119,Leu432,Asn453, Arg48,Ala119,Val432,Asn-453 and Arg48,Ser119,Val432,Asn453, were expressed in Escherichia coli together with human NADPH-P450 reductase and the recombinant proteins (in b...

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Veröffentlicht in:	Carcinogenesis (New York) 1999-08, Vol.20 (8), p.1607-1614
Hauptverfasser:	Shimada, Tsutomu, Watanabe, Junko, Kawajiri, Kaname, Sutter, Thomas R., Guengerich, F. Peter, Gillam, Elizabeth M.J., Inoue, Kiyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	12-dimethylbenz[a]anthracene 2-amino-3 2-amino-3-methylimidazo 3-amino-1 3-b]indole 4-dimethyl5H-pyrido 5-dimethylimidazo 5-f]quinoline 5-f]quinoxaline 8-dimethylimidazo Alleles Analytical, structural and metabolic biochemistry Aryl Hydrocarbon Hydroxylases B[a]P B[b]F B[c]P B[g]C benzo[a]pyrene benzo[b]fluoranthene benzo[c]phenanthrene benzo[g]chrysene Biological and medical sciences Carcinogens - metabolism CYP Cytochrome P-450 CYP1A1 - metabolism Cytochrome P-450 CYP1B1 Cytochrome P-450 CYP2C8 Cytochrome P-450 CYP2C9 Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism cytochrome P450 DB[a dibenzo[a diol DMBA Enzymes and enzyme inhibitors Escherichia coli - enzymology Estradiol - metabolism Estrone - metabolism Fundamental and applied biological sciences. Psychology hNPR human NADPH-P450 reductase Humans Hydroxylation l]P l]pyrene MeIQ MeIQx Oxidoreductases Progesterone - metabolism Steroid 16-alpha-Hydroxylase Testosterone - metabolism Trp-P-1 used in the text to designate the prefix `dihydroxydihydro' for individual polycyclic hydrocarbons
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