Type II diabetes mellitus and impaired glucose regulation in Caucasian children and adolescents with obesity living in Germany
BACKGROUND: Recent studies reported an increased prevalence of type II diabetes mellitus in obese children and adolescents, especially in specific ethnic subgroups. The aim of this study was to determine the prevalence of type II diabetes mellitus and impaired glucose regulation in a large group of...
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| Veröffentlicht in: | International Journal of Obesity 2004-02, Vol.28 (2), p.307-313 |
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| creator | Wabitsch, M Hauner, H Hertrampf, M Muche, R Hay, B Mayer, H Kratzer, W Debatin, K-M Heinze, E |
| description | BACKGROUND:
Recent studies reported an increased prevalence of type II diabetes mellitus in obese children and adolescents, especially in specific ethnic subgroups. The aim of this study was to determine the prevalence of type II diabetes mellitus and impaired glucose regulation in a large group of Caucasian children and adolescents with obesity living in Germany.
PATIENTS AND METHODS:
A total of 520 subjects (237 boys, 283 girls) (mean age: 14.0±2.0 y (range 8.9–20.4 y)) with a BMI>97th percentile, BMI-SDS: 2.7±0.5 (range 1.9–4.6), who were consecutively admitted to an in-patient obesity unit participated in the study. A 2-h oral glucose tolerance test (1.75 mg of glucose per kilogram of body weight) was performed before entering a weight-loss program and capillary blood glucose concentrations were measured. Patients were categorized into normal glucose regulation, impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and diabetes. In addition, fasting venous blood was taken to determine the circulating insulin, C-peptide and lipids. Insulin resistance was estimated by homeostatic model assessment.
RESULTS:
Type II diabetes was present in 1.5% (
n
=8) of the patients, two patients were admitted with already diagnosed type II diabetes and six patients were identified with yet unknown diabetes. IFG was detected in 3.7% (
n
=19) and IGT in 2.1% (
n
=11) of the patients. All together, in 6.7% (
n
=35) (95% confidence interval: 4.7–9.2%) of the patients, impaired glucose regulation (IFG, IGT) or diabetes was identified. These patients had a higher BMI-SDS, higher levels of fasting insulin and C-peptide and a higher insulin resistance index than the patients with normal glucose regulation. Risk factors for the occurrence of impaired glucose regulation were a BMI-SDS>2.5 as well as a positive parents' history for diabetes.
CONCLUSIONS:
This is the first report on the prevalence of type II diabetes in a large cohort of Caucasian children and adolescents with obesity living in Europe. Impaired glucose regulation and type II diabetes were present in a substantial proportion of the patients studied. Screening for diabetes in severely obese children and adolescents (BMI-SDS>2.5) is therefore recommended. Patients identified with impaired glucose regulation need specific treatment programs in order to prevent progression to diabetes. |
| doi_str_mv | 10.1038/sj.ijo.0802555 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_219313763</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A188449023</galeid><sourcerecordid>A188449023</sourcerecordid><originalsourceid>FETCH-LOGICAL-c455t-922014f2e9061194e5899130edcd47a00a42f57b2642bdeba456b1c7ae8a1da3</originalsourceid><addsrcrecordid>eNp1kU2P0zAQhiMEYsvClSOyQHBr13bsfBxXFSyVVuLSezSxJ60rxy6eBNQLv52URipIi3ywZD_PjGbeLHsr-ErwvLqjw8od4opXXGqtn2ULocpiqVVdPs8WPOflkutC32SviA6cc625fJndTJBUhdaL7Nf2dES22TDroMUBifXovRtGYhAsc_0RXELLdn40kZAl3I0eBhcDc4GtYTRADgIze-dtwvDHAhs9ksEwEPvphj2LLZIbTsy7Hy7szuYDph7C6XX2ogNP-Ga-b7Ptl8_b9dfl47eHzfr-cWmU1sOylpIL1UmseSFErVBXdS1yjtZYVQLnoGSny1YWSrYWW1C6aIUpASsQFvLb7P2l7DHF7yPS0BzimMLUsZGizkVeFvkEfbhAO_DYuNDFIYHpHZnmXlSVUjWXZ2r1BDUdi70zMWDnpvd_hE9_CXsEP-wp-vG8Q3qyskmRKGHXHJPrIZ0awZtz2A0dminsZg57Et7NU41tj_aKz-lOwMcZADLguwTBOLpyuuS6ruqJu7twNH2FHabrev7T-jd7YcG0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>219313763</pqid></control><display><type>article</type><title>Type II diabetes mellitus and impaired glucose regulation in Caucasian children and adolescents with obesity living in Germany</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>Nature</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Wabitsch, M ; Hauner, H ; Hertrampf, M ; Muche, R ; Hay, B ; Mayer, H ; Kratzer, W ; Debatin, K-M ; Heinze, E</creator><creatorcontrib>Wabitsch, M ; Hauner, H ; Hertrampf, M ; Muche, R ; Hay, B ; Mayer, H ; Kratzer, W ; Debatin, K-M ; Heinze, E</creatorcontrib><description>BACKGROUND:
Recent studies reported an increased prevalence of type II diabetes mellitus in obese children and adolescents, especially in specific ethnic subgroups. The aim of this study was to determine the prevalence of type II diabetes mellitus and impaired glucose regulation in a large group of Caucasian children and adolescents with obesity living in Germany.
PATIENTS AND METHODS:
A total of 520 subjects (237 boys, 283 girls) (mean age: 14.0±2.0 y (range 8.9–20.4 y)) with a BMI>97th percentile, BMI-SDS: 2.7±0.5 (range 1.9–4.6), who were consecutively admitted to an in-patient obesity unit participated in the study. A 2-h oral glucose tolerance test (1.75 mg of glucose per kilogram of body weight) was performed before entering a weight-loss program and capillary blood glucose concentrations were measured. Patients were categorized into normal glucose regulation, impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and diabetes. In addition, fasting venous blood was taken to determine the circulating insulin, C-peptide and lipids. Insulin resistance was estimated by homeostatic model assessment.
RESULTS:
Type II diabetes was present in 1.5% (
n
=8) of the patients, two patients were admitted with already diagnosed type II diabetes and six patients were identified with yet unknown diabetes. IFG was detected in 3.7% (
n
=19) and IGT in 2.1% (
n
=11) of the patients. All together, in 6.7% (
n
=35) (95% confidence interval: 4.7–9.2%) of the patients, impaired glucose regulation (IFG, IGT) or diabetes was identified. These patients had a higher BMI-SDS, higher levels of fasting insulin and C-peptide and a higher insulin resistance index than the patients with normal glucose regulation. Risk factors for the occurrence of impaired glucose regulation were a BMI-SDS>2.5 as well as a positive parents' history for diabetes.
CONCLUSIONS:
This is the first report on the prevalence of type II diabetes in a large cohort of Caucasian children and adolescents with obesity living in Europe. Impaired glucose regulation and type II diabetes were present in a substantial proportion of the patients studied. Screening for diabetes in severely obese children and adolescents (BMI-SDS>2.5) is therefore recommended. Patients identified with impaired glucose regulation need specific treatment programs in order to prevent progression to diabetes.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/sj.ijo.0802555</identifier><identifier>PMID: 14724655</identifier><identifier>CODEN: IJOBDP</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Acanthosis Nigricans - blood ; Adolescent ; Adolescents ; Aged ; Anthropometry ; Autoantibodies - blood ; Biological and medical sciences ; Blood ; Blood Glucose - metabolism ; Body weight ; Cardiovascular Diseases - genetics ; Child ; Children ; Children & youth ; Diabetes ; Diabetes Mellitus, Type 1 - immunology ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - etiology ; Diabetes Mellitus, Type 2 - genetics ; Epidemiology ; Families & family life ; Female ; Genetic Predisposition to Disease ; Germany - epidemiology ; Glucose ; Glucose Intolerance - epidemiology ; Glucose Intolerance - etiology ; Glucose Tolerance Test ; Hair ; Health Promotion and Disease Prevention ; Hospitals ; Humans ; Insulin Resistance ; Internal Medicine ; Lipids ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Obesity ; Obesity - blood ; Obesity - complications ; Obesity - genetics ; Parents & parenting ; Patients ; Pediatrics ; Peptides ; Prevalence ; Public Health ; Risk Factors ; Teenagers ; White people</subject><ispartof>International Journal of Obesity, 2004-02, Vol.28 (2), p.307-313</ispartof><rights>Springer Nature Limited 2004</rights><rights>2004 INIST-CNRS</rights><rights>COPYRIGHT 2004 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Feb 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-922014f2e9061194e5899130edcd47a00a42f57b2642bdeba456b1c7ae8a1da3</citedby><cites>FETCH-LOGICAL-c455t-922014f2e9061194e5899130edcd47a00a42f57b2642bdeba456b1c7ae8a1da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.ijo.0802555$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.ijo.0802555$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15705989$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14724655$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wabitsch, M</creatorcontrib><creatorcontrib>Hauner, H</creatorcontrib><creatorcontrib>Hertrampf, M</creatorcontrib><creatorcontrib>Muche, R</creatorcontrib><creatorcontrib>Hay, B</creatorcontrib><creatorcontrib>Mayer, H</creatorcontrib><creatorcontrib>Kratzer, W</creatorcontrib><creatorcontrib>Debatin, K-M</creatorcontrib><creatorcontrib>Heinze, E</creatorcontrib><title>Type II diabetes mellitus and impaired glucose regulation in Caucasian children and adolescents with obesity living in Germany</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes Relat Metab Disord</addtitle><description>BACKGROUND:
Recent studies reported an increased prevalence of type II diabetes mellitus in obese children and adolescents, especially in specific ethnic subgroups. The aim of this study was to determine the prevalence of type II diabetes mellitus and impaired glucose regulation in a large group of Caucasian children and adolescents with obesity living in Germany.
PATIENTS AND METHODS:
A total of 520 subjects (237 boys, 283 girls) (mean age: 14.0±2.0 y (range 8.9–20.4 y)) with a BMI>97th percentile, BMI-SDS: 2.7±0.5 (range 1.9–4.6), who were consecutively admitted to an in-patient obesity unit participated in the study. A 2-h oral glucose tolerance test (1.75 mg of glucose per kilogram of body weight) was performed before entering a weight-loss program and capillary blood glucose concentrations were measured. Patients were categorized into normal glucose regulation, impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and diabetes. In addition, fasting venous blood was taken to determine the circulating insulin, C-peptide and lipids. Insulin resistance was estimated by homeostatic model assessment.
RESULTS:
Type II diabetes was present in 1.5% (
n
=8) of the patients, two patients were admitted with already diagnosed type II diabetes and six patients were identified with yet unknown diabetes. IFG was detected in 3.7% (
n
=19) and IGT in 2.1% (
n
=11) of the patients. All together, in 6.7% (
n
=35) (95% confidence interval: 4.7–9.2%) of the patients, impaired glucose regulation (IFG, IGT) or diabetes was identified. These patients had a higher BMI-SDS, higher levels of fasting insulin and C-peptide and a higher insulin resistance index than the patients with normal glucose regulation. Risk factors for the occurrence of impaired glucose regulation were a BMI-SDS>2.5 as well as a positive parents' history for diabetes.
CONCLUSIONS:
This is the first report on the prevalence of type II diabetes in a large cohort of Caucasian children and adolescents with obesity living in Europe. Impaired glucose regulation and type II diabetes were present in a substantial proportion of the patients studied. Screening for diabetes in severely obese children and adolescents (BMI-SDS>2.5) is therefore recommended. Patients identified with impaired glucose regulation need specific treatment programs in order to prevent progression to diabetes.</description><subject>Acanthosis Nigricans - blood</subject><subject>Adolescent</subject><subject>Adolescents</subject><subject>Aged</subject><subject>Anthropometry</subject><subject>Autoantibodies - blood</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Blood Glucose - metabolism</subject><subject>Body weight</subject><subject>Cardiovascular Diseases - genetics</subject><subject>Child</subject><subject>Children</subject><subject>Children & youth</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 1 - immunology</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - etiology</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Epidemiology</subject><subject>Families & family life</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Germany - epidemiology</subject><subject>Glucose</subject><subject>Glucose Intolerance - epidemiology</subject><subject>Glucose Intolerance - etiology</subject><subject>Glucose Tolerance Test</subject><subject>Hair</subject><subject>Health Promotion and Disease Prevention</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Insulin Resistance</subject><subject>Internal Medicine</subject><subject>Lipids</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - complications</subject><subject>Obesity - genetics</subject><subject>Parents & parenting</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Peptides</subject><subject>Prevalence</subject><subject>Public Health</subject><subject>Risk Factors</subject><subject>Teenagers</subject><subject>White people</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU2P0zAQhiMEYsvClSOyQHBr13bsfBxXFSyVVuLSezSxJ60rxy6eBNQLv52URipIi3ywZD_PjGbeLHsr-ErwvLqjw8od4opXXGqtn2ULocpiqVVdPs8WPOflkutC32SviA6cc625fJndTJBUhdaL7Nf2dES22TDroMUBifXovRtGYhAsc_0RXELLdn40kZAl3I0eBhcDc4GtYTRADgIze-dtwvDHAhs9ksEwEPvphj2LLZIbTsy7Hy7szuYDph7C6XX2ogNP-Ga-b7Ptl8_b9dfl47eHzfr-cWmU1sOylpIL1UmseSFErVBXdS1yjtZYVQLnoGSny1YWSrYWW1C6aIUpASsQFvLb7P2l7DHF7yPS0BzimMLUsZGizkVeFvkEfbhAO_DYuNDFIYHpHZnmXlSVUjWXZ2r1BDUdi70zMWDnpvd_hE9_CXsEP-wp-vG8Q3qyskmRKGHXHJPrIZ0awZtz2A0dminsZg57Et7NU41tj_aKz-lOwMcZADLguwTBOLpyuuS6ruqJu7twNH2FHabrev7T-jd7YcG0</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>Wabitsch, M</creator><creator>Hauner, H</creator><creator>Hertrampf, M</creator><creator>Muche, R</creator><creator>Hay, B</creator><creator>Mayer, H</creator><creator>Kratzer, W</creator><creator>Debatin, K-M</creator><creator>Heinze, E</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20040201</creationdate><title>Type II diabetes mellitus and impaired glucose regulation in Caucasian children and adolescents with obesity living in Germany</title><author>Wabitsch, M ; Hauner, H ; Hertrampf, M ; Muche, R ; Hay, B ; Mayer, H ; Kratzer, W ; Debatin, K-M ; Heinze, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-922014f2e9061194e5899130edcd47a00a42f57b2642bdeba456b1c7ae8a1da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acanthosis Nigricans - blood</topic><topic>Adolescent</topic><topic>Adolescents</topic><topic>Aged</topic><topic>Anthropometry</topic><topic>Autoantibodies - blood</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Blood Glucose - metabolism</topic><topic>Body weight</topic><topic>Cardiovascular Diseases - genetics</topic><topic>Child</topic><topic>Children</topic><topic>Children & youth</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 1 - immunology</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetes Mellitus, Type 2 - etiology</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Epidemiology</topic><topic>Families & family life</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Germany - epidemiology</topic><topic>Glucose</topic><topic>Glucose Intolerance - epidemiology</topic><topic>Glucose Intolerance - etiology</topic><topic>Glucose Tolerance Test</topic><topic>Hair</topic><topic>Health Promotion and Disease Prevention</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Insulin Resistance</topic><topic>Internal Medicine</topic><topic>Lipids</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Obesity - complications</topic><topic>Obesity - genetics</topic><topic>Parents & parenting</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Peptides</topic><topic>Prevalence</topic><topic>Public Health</topic><topic>Risk Factors</topic><topic>Teenagers</topic><topic>White people</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wabitsch, M</creatorcontrib><creatorcontrib>Hauner, H</creatorcontrib><creatorcontrib>Hertrampf, M</creatorcontrib><creatorcontrib>Muche, R</creatorcontrib><creatorcontrib>Hay, B</creatorcontrib><creatorcontrib>Mayer, H</creatorcontrib><creatorcontrib>Kratzer, W</creatorcontrib><creatorcontrib>Debatin, K-M</creatorcontrib><creatorcontrib>Heinze, E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wabitsch, M</au><au>Hauner, H</au><au>Hertrampf, M</au><au>Muche, R</au><au>Hay, B</au><au>Mayer, H</au><au>Kratzer, W</au><au>Debatin, K-M</au><au>Heinze, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Type II diabetes mellitus and impaired glucose regulation in Caucasian children and adolescents with obesity living in Germany</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes Relat Metab Disord</addtitle><date>2004-02-01</date><risdate>2004</risdate><volume>28</volume><issue>2</issue><spage>307</spage><epage>313</epage><pages>307-313</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><coden>IJOBDP</coden><abstract>BACKGROUND:
Recent studies reported an increased prevalence of type II diabetes mellitus in obese children and adolescents, especially in specific ethnic subgroups. The aim of this study was to determine the prevalence of type II diabetes mellitus and impaired glucose regulation in a large group of Caucasian children and adolescents with obesity living in Germany.
PATIENTS AND METHODS:
A total of 520 subjects (237 boys, 283 girls) (mean age: 14.0±2.0 y (range 8.9–20.4 y)) with a BMI>97th percentile, BMI-SDS: 2.7±0.5 (range 1.9–4.6), who were consecutively admitted to an in-patient obesity unit participated in the study. A 2-h oral glucose tolerance test (1.75 mg of glucose per kilogram of body weight) was performed before entering a weight-loss program and capillary blood glucose concentrations were measured. Patients were categorized into normal glucose regulation, impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and diabetes. In addition, fasting venous blood was taken to determine the circulating insulin, C-peptide and lipids. Insulin resistance was estimated by homeostatic model assessment.
RESULTS:
Type II diabetes was present in 1.5% (
n
=8) of the patients, two patients were admitted with already diagnosed type II diabetes and six patients were identified with yet unknown diabetes. IFG was detected in 3.7% (
n
=19) and IGT in 2.1% (
n
=11) of the patients. All together, in 6.7% (
n
=35) (95% confidence interval: 4.7–9.2%) of the patients, impaired glucose regulation (IFG, IGT) or diabetes was identified. These patients had a higher BMI-SDS, higher levels of fasting insulin and C-peptide and a higher insulin resistance index than the patients with normal glucose regulation. Risk factors for the occurrence of impaired glucose regulation were a BMI-SDS>2.5 as well as a positive parents' history for diabetes.
CONCLUSIONS:
This is the first report on the prevalence of type II diabetes in a large cohort of Caucasian children and adolescents with obesity living in Europe. Impaired glucose regulation and type II diabetes were present in a substantial proportion of the patients studied. Screening for diabetes in severely obese children and adolescents (BMI-SDS>2.5) is therefore recommended. Patients identified with impaired glucose regulation need specific treatment programs in order to prevent progression to diabetes.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>14724655</pmid><doi>10.1038/sj.ijo.0802555</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-0565 |
| ispartof | International Journal of Obesity, 2004-02, Vol.28 (2), p.307-313 |
| issn | 0307-0565 1476-5497 |
| language | eng |
| recordid | cdi_proquest_journals_219313763 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acanthosis Nigricans - blood Adolescent Adolescents Aged Anthropometry Autoantibodies - blood Biological and medical sciences Blood Blood Glucose - metabolism Body weight Cardiovascular Diseases - genetics Child Children Children & youth Diabetes Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - genetics Epidemiology Families & family life Female Genetic Predisposition to Disease Germany - epidemiology Glucose Glucose Intolerance - epidemiology Glucose Intolerance - etiology Glucose Tolerance Test Hair Health Promotion and Disease Prevention Hospitals Humans Insulin Resistance Internal Medicine Lipids Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Obesity Obesity - blood Obesity - complications Obesity - genetics Parents & parenting Patients Pediatrics Peptides Prevalence Public Health Risk Factors Teenagers White people |
| title | Type II diabetes mellitus and impaired glucose regulation in Caucasian children and adolescents with obesity living in Germany |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T22%3A41%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Type%20II%20diabetes%20mellitus%20and%20impaired%20glucose%20regulation%20in%20Caucasian%20children%20and%20adolescents%20with%20obesity%20living%20in%20Germany&rft.jtitle=International%20Journal%20of%20Obesity&rft.au=Wabitsch,%20M&rft.date=2004-02-01&rft.volume=28&rft.issue=2&rft.spage=307&rft.epage=313&rft.pages=307-313&rft.issn=0307-0565&rft.eissn=1476-5497&rft.coden=IJOBDP&rft_id=info:doi/10.1038/sj.ijo.0802555&rft_dat=%3Cgale_proqu%3EA188449023%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=219313763&rft_id=info:pmid/14724655&rft_galeid=A188449023&rfr_iscdi=true |