Improved glucose homeostasis in mice overexpressing human UCP3: a role for AMP-kinase?
OBJECTIVE: An unexplained phenotype of mice overexpressing human UCP3 is their improved glucose homeostasis. Since overexpression of UCP3 might affect the energy charge of the cell, we investigated whether these mice have an increased AMP-activated protein kinase (AMPK) activity. METHODS: Mitochondr...
Gespeichert in:
| Veröffentlicht in: | International Journal of Obesity 2004-06, Vol.28 (6), p.824-828 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 828 |
|---|---|
| container_issue | 6 |
| container_start_page | 824 |
| container_title | International Journal of Obesity |
| container_volume | 28 |
| creator | Schrauwen, P Hardie, D G Roorda, B Clapham, J C Abuin, A Thomason-Hughes, M Green, K Frederik, P M Hesselink, M K C |
| description | OBJECTIVE:
An unexplained phenotype of mice overexpressing human UCP3 is their improved glucose homeostasis. Since overexpression of UCP3 might affect the energy charge of the cell, we investigated whether these mice have an increased AMP-activated protein kinase (AMPK) activity.
METHODS:
Mitochondrial localisation of UCP3 was determined by immunoelectronmicroscopy and AMPK activity was measured in medial gastrocnemius of control mice and mice overexpressing human UCP3.
RESULTS:
Mice overexpressing human UCP3 had 5.8 fold higher levels of UCP3 protein, for which mitochondrial localisation was confirmed by immunoelectronmicroscopy. The ATP/AMP ratio was significantly lower in mice over-expressing UCP3 compared to the wild-type (10.9±1.6
vs
20.4±1.9 AU,
P
=0.03). Over-expression of UCP3 resulted in increased AMPK
α
1 activity (1.23±0.05
vs
1.00±0.06 normalized values,
P
=0.004) and a tendency towards increased AMPK
α
2 activity (1.18±0.08
vs
1.00±0.10 normalized values,
P
=0.08).
CONCLUSION:
Increased AMPK activity provides a plausible explanation for the improved glucose tolerance characteristic for these mice. |
| doi_str_mv | 10.1038/sj.ijo.0802629 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_219312802</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A188448899</galeid><sourcerecordid>A188448899</sourcerecordid><originalsourceid>FETCH-LOGICAL-c561t-24394611abc65346020c148916a6d04bcbc6e06d84f4ae38d574059a6962509b3</originalsourceid><addsrcrecordid>eNp1kU2LFDEQhoMo7uzo1aMEZb31bNL56MSLDIMfCyvuwfUaMun0TMbuZEx1i_57I9OwK6zUoaDqqSrqfRF6QcmKEqYu4bAKh7QiitSy1o_QgvJGVoLr5jFaEEaaiggpztA5wIEQIgSpn6IzWhLnhC3Qt6vhmNNP3-JdP7kEHu_T4BOMFgLgEPEQnMcFyP7XMXuAEHd4Pw024tvNDXuLLc6p97hLGa8_31TfQ7Tg3z1DTzrbg38-5yW6_fD-6-ZTdf3l49VmfV05IelY1ZxpLim1WycF45LUxFGuNJVWtoRvXal7IlvFO249U61oOBHaSi1rQfSWLdGr097yxI_Jw2gOacqxnDQ11YzWRZcCvT5BO9t7E2KXxmzdEMCZNVWKc6W0LtTqAapE64sGKfoulPo_A2_uDey97cc9pH4aQ4rw4GaXE0D2nTnmMNj821Bi_rpo4GCKi2Z2sQy8nL-atoNv7_DZtgJczIAFZ_su2-gC3OOahqkSS3R54qC04s7nO3n-c_oPOuaxOw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>219312802</pqid></control><display><type>article</type><title>Improved glucose homeostasis in mice overexpressing human UCP3: a role for AMP-kinase?</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Nature Journals Online</source><creator>Schrauwen, P ; Hardie, D G ; Roorda, B ; Clapham, J C ; Abuin, A ; Thomason-Hughes, M ; Green, K ; Frederik, P M ; Hesselink, M K C</creator><creatorcontrib>Schrauwen, P ; Hardie, D G ; Roorda, B ; Clapham, J C ; Abuin, A ; Thomason-Hughes, M ; Green, K ; Frederik, P M ; Hesselink, M K C</creatorcontrib><description>OBJECTIVE:
An unexplained phenotype of mice overexpressing human UCP3 is their improved glucose homeostasis. Since overexpression of UCP3 might affect the energy charge of the cell, we investigated whether these mice have an increased AMP-activated protein kinase (AMPK) activity.
METHODS:
Mitochondrial localisation of UCP3 was determined by immunoelectronmicroscopy and AMPK activity was measured in medial gastrocnemius of control mice and mice overexpressing human UCP3.
RESULTS:
Mice overexpressing human UCP3 had 5.8 fold higher levels of UCP3 protein, for which mitochondrial localisation was confirmed by immunoelectronmicroscopy. The ATP/AMP ratio was significantly lower in mice over-expressing UCP3 compared to the wild-type (10.9±1.6
vs
20.4±1.9 AU,
P
=0.03). Over-expression of UCP3 resulted in increased AMPK
α
1 activity (1.23±0.05
vs
1.00±0.06 normalized values,
P
=0.004) and a tendency towards increased AMPK
α
2 activity (1.18±0.08
vs
1.00±0.10 normalized values,
P
=0.08).
CONCLUSION:
Increased AMPK activity provides a plausible explanation for the improved glucose tolerance characteristic for these mice.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/sj.ijo.0802629</identifier><identifier>PMID: 15024403</identifier><identifier>CODEN: IJOBDP</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adenine Nucleotides - metabolism ; Adenylate Kinase - metabolism ; Animal care ; Animals ; Biological and medical sciences ; Biology ; Carrier Proteins - analysis ; Carrier Proteins - genetics ; Diabetes ; Energy Metabolism ; Epidemiology ; Glucose ; Glucose - metabolism ; Health Promotion and Disease Prevention ; Homeostasis ; Homeostasis - physiology ; Internal Medicine ; Ion Channels ; Kinases ; Laboratory animals ; Localization ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Metabolism ; Mice ; Mice, Inbred Strains ; Microscopy, Immunoelectron - methods ; Mitochondrial Proteins ; Musculoskeletal system ; Obesity ; Phenotype ; Proteins ; Public Health ; short-communication ; Uncoupling Agents - analysis ; Uncoupling Protein 3</subject><ispartof>International Journal of Obesity, 2004-06, Vol.28 (6), p.824-828</ispartof><rights>Springer Nature Limited 2004</rights><rights>2004 INIST-CNRS</rights><rights>COPYRIGHT 2004 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jun 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c561t-24394611abc65346020c148916a6d04bcbc6e06d84f4ae38d574059a6962509b3</citedby><cites>FETCH-LOGICAL-c561t-24394611abc65346020c148916a6d04bcbc6e06d84f4ae38d574059a6962509b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.ijo.0802629$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.ijo.0802629$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15773838$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15024403$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schrauwen, P</creatorcontrib><creatorcontrib>Hardie, D G</creatorcontrib><creatorcontrib>Roorda, B</creatorcontrib><creatorcontrib>Clapham, J C</creatorcontrib><creatorcontrib>Abuin, A</creatorcontrib><creatorcontrib>Thomason-Hughes, M</creatorcontrib><creatorcontrib>Green, K</creatorcontrib><creatorcontrib>Frederik, P M</creatorcontrib><creatorcontrib>Hesselink, M K C</creatorcontrib><title>Improved glucose homeostasis in mice overexpressing human UCP3: a role for AMP-kinase?</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes Relat Metab Disord</addtitle><description>OBJECTIVE:
An unexplained phenotype of mice overexpressing human UCP3 is their improved glucose homeostasis. Since overexpression of UCP3 might affect the energy charge of the cell, we investigated whether these mice have an increased AMP-activated protein kinase (AMPK) activity.
METHODS:
Mitochondrial localisation of UCP3 was determined by immunoelectronmicroscopy and AMPK activity was measured in medial gastrocnemius of control mice and mice overexpressing human UCP3.
RESULTS:
Mice overexpressing human UCP3 had 5.8 fold higher levels of UCP3 protein, for which mitochondrial localisation was confirmed by immunoelectronmicroscopy. The ATP/AMP ratio was significantly lower in mice over-expressing UCP3 compared to the wild-type (10.9±1.6
vs
20.4±1.9 AU,
P
=0.03). Over-expression of UCP3 resulted in increased AMPK
α
1 activity (1.23±0.05
vs
1.00±0.06 normalized values,
P
=0.004) and a tendency towards increased AMPK
α
2 activity (1.18±0.08
vs
1.00±0.10 normalized values,
P
=0.08).
CONCLUSION:
Increased AMPK activity provides a plausible explanation for the improved glucose tolerance characteristic for these mice.</description><subject>Adenine Nucleotides - metabolism</subject><subject>Adenylate Kinase - metabolism</subject><subject>Animal care</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biology</subject><subject>Carrier Proteins - analysis</subject><subject>Carrier Proteins - genetics</subject><subject>Diabetes</subject><subject>Energy Metabolism</subject><subject>Epidemiology</subject><subject>Glucose</subject><subject>Glucose - metabolism</subject><subject>Health Promotion and Disease Prevention</subject><subject>Homeostasis</subject><subject>Homeostasis - physiology</subject><subject>Internal Medicine</subject><subject>Ion Channels</subject><subject>Kinases</subject><subject>Laboratory animals</subject><subject>Localization</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Microscopy, Immunoelectron - methods</subject><subject>Mitochondrial Proteins</subject><subject>Musculoskeletal system</subject><subject>Obesity</subject><subject>Phenotype</subject><subject>Proteins</subject><subject>Public Health</subject><subject>short-communication</subject><subject>Uncoupling Agents - analysis</subject><subject>Uncoupling Protein 3</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU2LFDEQhoMo7uzo1aMEZb31bNL56MSLDIMfCyvuwfUaMun0TMbuZEx1i_57I9OwK6zUoaDqqSrqfRF6QcmKEqYu4bAKh7QiitSy1o_QgvJGVoLr5jFaEEaaiggpztA5wIEQIgSpn6IzWhLnhC3Qt6vhmNNP3-JdP7kEHu_T4BOMFgLgEPEQnMcFyP7XMXuAEHd4Pw024tvNDXuLLc6p97hLGa8_31TfQ7Tg3z1DTzrbg38-5yW6_fD-6-ZTdf3l49VmfV05IelY1ZxpLim1WycF45LUxFGuNJVWtoRvXal7IlvFO249U61oOBHaSi1rQfSWLdGr097yxI_Jw2gOacqxnDQ11YzWRZcCvT5BO9t7E2KXxmzdEMCZNVWKc6W0LtTqAapE64sGKfoulPo_A2_uDey97cc9pH4aQ4rw4GaXE0D2nTnmMNj821Bi_rpo4GCKi2Z2sQy8nL-atoNv7_DZtgJczIAFZ_su2-gC3OOahqkSS3R54qC04s7nO3n-c_oPOuaxOw</recordid><startdate>20040601</startdate><enddate>20040601</enddate><creator>Schrauwen, P</creator><creator>Hardie, D G</creator><creator>Roorda, B</creator><creator>Clapham, J C</creator><creator>Abuin, A</creator><creator>Thomason-Hughes, M</creator><creator>Green, K</creator><creator>Frederik, P M</creator><creator>Hesselink, M K C</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20040601</creationdate><title>Improved glucose homeostasis in mice overexpressing human UCP3: a role for AMP-kinase?</title><author>Schrauwen, P ; Hardie, D G ; Roorda, B ; Clapham, J C ; Abuin, A ; Thomason-Hughes, M ; Green, K ; Frederik, P M ; Hesselink, M K C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c561t-24394611abc65346020c148916a6d04bcbc6e06d84f4ae38d574059a6962509b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adenine Nucleotides - metabolism</topic><topic>Adenylate Kinase - metabolism</topic><topic>Animal care</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biology</topic><topic>Carrier Proteins - analysis</topic><topic>Carrier Proteins - genetics</topic><topic>Diabetes</topic><topic>Energy Metabolism</topic><topic>Epidemiology</topic><topic>Glucose</topic><topic>Glucose - metabolism</topic><topic>Health Promotion and Disease Prevention</topic><topic>Homeostasis</topic><topic>Homeostasis - physiology</topic><topic>Internal Medicine</topic><topic>Ion Channels</topic><topic>Kinases</topic><topic>Laboratory animals</topic><topic>Localization</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Metabolism</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Microscopy, Immunoelectron - methods</topic><topic>Mitochondrial Proteins</topic><topic>Musculoskeletal system</topic><topic>Obesity</topic><topic>Phenotype</topic><topic>Proteins</topic><topic>Public Health</topic><topic>short-communication</topic><topic>Uncoupling Agents - analysis</topic><topic>Uncoupling Protein 3</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schrauwen, P</creatorcontrib><creatorcontrib>Hardie, D G</creatorcontrib><creatorcontrib>Roorda, B</creatorcontrib><creatorcontrib>Clapham, J C</creatorcontrib><creatorcontrib>Abuin, A</creatorcontrib><creatorcontrib>Thomason-Hughes, M</creatorcontrib><creatorcontrib>Green, K</creatorcontrib><creatorcontrib>Frederik, P M</creatorcontrib><creatorcontrib>Hesselink, M K C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schrauwen, P</au><au>Hardie, D G</au><au>Roorda, B</au><au>Clapham, J C</au><au>Abuin, A</au><au>Thomason-Hughes, M</au><au>Green, K</au><au>Frederik, P M</au><au>Hesselink, M K C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improved glucose homeostasis in mice overexpressing human UCP3: a role for AMP-kinase?</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes Relat Metab Disord</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>28</volume><issue>6</issue><spage>824</spage><epage>828</epage><pages>824-828</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><coden>IJOBDP</coden><abstract>OBJECTIVE:
An unexplained phenotype of mice overexpressing human UCP3 is their improved glucose homeostasis. Since overexpression of UCP3 might affect the energy charge of the cell, we investigated whether these mice have an increased AMP-activated protein kinase (AMPK) activity.
METHODS:
Mitochondrial localisation of UCP3 was determined by immunoelectronmicroscopy and AMPK activity was measured in medial gastrocnemius of control mice and mice overexpressing human UCP3.
RESULTS:
Mice overexpressing human UCP3 had 5.8 fold higher levels of UCP3 protein, for which mitochondrial localisation was confirmed by immunoelectronmicroscopy. The ATP/AMP ratio was significantly lower in mice over-expressing UCP3 compared to the wild-type (10.9±1.6
vs
20.4±1.9 AU,
P
=0.03). Over-expression of UCP3 resulted in increased AMPK
α
1 activity (1.23±0.05
vs
1.00±0.06 normalized values,
P
=0.004) and a tendency towards increased AMPK
α
2 activity (1.18±0.08
vs
1.00±0.10 normalized values,
P
=0.08).
CONCLUSION:
Increased AMPK activity provides a plausible explanation for the improved glucose tolerance characteristic for these mice.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>15024403</pmid><doi>10.1038/sj.ijo.0802629</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-0565 |
| ispartof | International Journal of Obesity, 2004-06, Vol.28 (6), p.824-828 |
| issn | 0307-0565 1476-5497 |
| language | eng |
| recordid | cdi_proquest_journals_219312802 |
| source | MEDLINE; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Nature Journals Online |
| subjects | Adenine Nucleotides - metabolism Adenylate Kinase - metabolism Animal care Animals Biological and medical sciences Biology Carrier Proteins - analysis Carrier Proteins - genetics Diabetes Energy Metabolism Epidemiology Glucose Glucose - metabolism Health Promotion and Disease Prevention Homeostasis Homeostasis - physiology Internal Medicine Ion Channels Kinases Laboratory animals Localization Medical sciences Medicine Medicine & Public Health Metabolic Diseases Metabolism Mice Mice, Inbred Strains Microscopy, Immunoelectron - methods Mitochondrial Proteins Musculoskeletal system Obesity Phenotype Proteins Public Health short-communication Uncoupling Agents - analysis Uncoupling Protein 3 |
| title | Improved glucose homeostasis in mice overexpressing human UCP3: a role for AMP-kinase? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T06%3A42%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Improved%20glucose%20homeostasis%20in%20mice%20overexpressing%20human%20UCP3:%20a%20role%20for%20AMP-kinase?&rft.jtitle=International%20Journal%20of%20Obesity&rft.au=Schrauwen,%20P&rft.date=2004-06-01&rft.volume=28&rft.issue=6&rft.spage=824&rft.epage=828&rft.pages=824-828&rft.issn=0307-0565&rft.eissn=1476-5497&rft.coden=IJOBDP&rft_id=info:doi/10.1038/sj.ijo.0802629&rft_dat=%3Cgale_proqu%3EA188448899%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=219312802&rft_id=info:pmid/15024403&rft_galeid=A188448899&rfr_iscdi=true |