impact of weight change on cardiovascular disease risk factors in young black and white adults: the CARDIA study
OBJECTIVE: To quantify the relation between weight change and change in blood pressure, lipids and insulin levels, and determine if this relation differs by race or initial level of obesity. DESIGN: Longitudinal cohort study. SETTING AND PARTICIPANTS: Community-based sample of 3325 black and white m...
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| Veröffentlicht in: | International Journal of Obesity 2003-03, Vol.27 (3), p.369-376 |
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| creator | Norman, J.E Bild, D Lewis, C.E Liu, K Smith West, D |
| description | OBJECTIVE: To quantify the relation between weight change and change in blood pressure, lipids and insulin levels, and determine if this relation differs by race or initial level of obesity. DESIGN: Longitudinal cohort study. SETTING AND PARTICIPANTS: Community-based sample of 3325 black and white men and women aged 18-30 y from four centers followed for 10 y. Women pregnant at baseline or 10th year exam and persons without a recorded weight at both exams were excluded. Participants whose baseline BMI was >=25 kg/m2 were classified as overweight. Height, weight, HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), fasting triglycerides, fasting insulin, and blood pressure were measured at baseline and Year 10. RESULTS: The mean (s.d.) of weight gained over 10 y was 10.5 (10.0) kg (black men), 11.7 (11.0) (black women), 7.7 (8.0) (white men), and 7.2 (10.0) (white women). An increase in weight was associated with adverse changes in all factors in all race-sex groups. For example, a 9.1 kg (20-lb) weight increase in persons not overweight at baseline predicted an increase in LDL-C ranging from 0.23 mmol/l in black women to 0.28 mmol/l in black men and a decrease in HDL-C from 0.09 mmol/l (white women) to 0.11 mmol/l (white men) (all P |
| doi_str_mv | 10.1038/sj.ijo.0802243 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_219295748</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A188456486</galeid><sourcerecordid>A188456486</sourcerecordid><originalsourceid>FETCH-LOGICAL-c570t-63d99efb0bd5dd229c60f8cff78075b6263de1f6b22ba97e5ee94e150c60cded3</originalsourceid><addsrcrecordid>eNp1kcFv0zAUxiMEYmVw5QZYSHBr5zix43CrugGTJiEBO1uO_dy4S-3Odpj63-MpEYUD8sHSe7_ve37-iuJ1iVclrvhF3K3szq8wx4TU1ZNiUdYNW9K6bZ4WC1zhZokpo2fFixh3GGNKMXlenJWEkTbXF8XB7g9SJeQNegC77RNSvXRbQN4hJYO2_peMahxkQNpGkBFQsPEOmSzyISLr0NGPbou6Qao7JJ1GD71NgKQehxQ_odQD2qy_X16vUUyjPr4snhk5RHg13-fF7eern5uvy5tvX64365ulog1OS1bptgXT4U5TrQlpFcOGK2MajhvaMZIBKA3rCOlk2wAFaGsoKc6c0qCr8-L95HsI_n6EmMTOj8HlkYKUbd6-qXmGVhO0lQMI64xPQap8NOyt8g6MzfV1yXlNWc1ZFnz8S9CDHFIf_TAm6138F5ydVfAxBjDiEOxehqMosXhMTsSdyMmJObkseDu_d-z2oE_4HFUGPsxADkQOJkinbDxxNeOsrB6NLiYu5lZOMpwW_-_oN5PCyTQG-GN56r-b-kZ6Ibc5f3H7g-D82Rg3Fedt9RvD98RD</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>219295748</pqid></control><display><type>article</type><title>impact of weight change on cardiovascular disease risk factors in young black and white adults: the CARDIA study</title><source>MEDLINE</source><source>Nature</source><source>EZB-FREE-00999 freely available EZB journals</source><source>SpringerLink Journals - AutoHoldings</source><creator>Norman, J.E ; Bild, D ; Lewis, C.E ; Liu, K ; Smith West, D</creator><creatorcontrib>Norman, J.E ; Bild, D ; Lewis, C.E ; Liu, K ; Smith West, D ; CARDIA Study</creatorcontrib><description>OBJECTIVE: To quantify the relation between weight change and change in blood pressure, lipids and insulin levels, and determine if this relation differs by race or initial level of obesity. DESIGN: Longitudinal cohort study. SETTING AND PARTICIPANTS: Community-based sample of 3325 black and white men and women aged 18-30 y from four centers followed for 10 y. Women pregnant at baseline or 10th year exam and persons without a recorded weight at both exams were excluded. Participants whose baseline BMI was >=25 kg/m2 were classified as overweight. Height, weight, HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), fasting triglycerides, fasting insulin, and blood pressure were measured at baseline and Year 10. RESULTS: The mean (s.d.) of weight gained over 10 y was 10.5 (10.0) kg (black men), 11.7 (11.0) (black women), 7.7 (8.0) (white men), and 7.2 (10.0) (white women). An increase in weight was associated with adverse changes in all factors in all race-sex groups. For example, a 9.1 kg (20-lb) weight increase in persons not overweight at baseline predicted an increase in LDL-C ranging from 0.23 mmol/l in black women to 0.28 mmol/l in black men and a decrease in HDL-C from 0.09 mmol/l (white women) to 0.11 mmol/l (white men) (all P<0.0001). The estimated change in triglycerides was greater in white than in black participants (P<0.02); no other racial differences were found. Changes in triglycerides (P<0.00001) and fasting insulin (P=0.004) were greater in men than in women. Only for LDL-C was a weight change-associated increase significantly different (greater, P<0.001) for nonoverweight persons than for those overweight at baseline. None of these associations were highly specific. Mean levels of LDL-C, HDL-C, and systolic blood pressure improved among all those who lost or did not gain weight. CONCLUSIONS: A 10 y weight gain in young adults of both races and sexes tends to confer adverse changes in their levels of LDL-C, HDL-C, triglycerides, fasting insulin, and blood pressure. This effect occurs regardless of initial weight, age, race, or gender.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/sj.ijo.0802243</identifier><identifier>PMID: 12629565</identifier><identifier>CODEN: IJOBDP</identifier><language>eng</language><publisher>London: Nature Publishing Group</publisher><subject>Adolescent ; Adult ; Analysis. Health state ; Biological and medical sciences ; Black or African American ; Black People ; Blacks ; Blood Pressure ; Body mass index ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - ethnology ; Cardiovascular Diseases - etiology ; Cholesterol ; Cohort Studies ; Epidemiology ; fasting ; Female ; gender ; General aspects ; Health Promotion and Disease Prevention ; Health risks ; High density lipoprotein ; high density lipoprotein cholesterol ; Humans ; Insulin ; Insulin - blood ; Internal Medicine ; Linear Models ; Lipids ; Lipids - blood ; Longitudinal Studies ; Low density lipoprotein ; low density lipoprotein cholesterol ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; men ; Metabolic Diseases ; Obesity ; Odds Ratio ; Overweight ; pregnant women ; Public Health ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Race ; races ; Risk Factors ; systolic blood pressure ; triacylglycerols ; Triglycerides ; United States - epidemiology ; weight gain ; Weight Gain - physiology ; Weight Loss - physiology ; White People ; Whites ; Women ; Young adults</subject><ispartof>International Journal of Obesity, 2003-03, Vol.27 (3), p.369-376</ispartof><rights>Springer Nature Limited 2003</rights><rights>2003 INIST-CNRS</rights><rights>COPYRIGHT 2003 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c570t-63d99efb0bd5dd229c60f8cff78075b6263de1f6b22ba97e5ee94e150c60cded3</citedby><cites>FETCH-LOGICAL-c570t-63d99efb0bd5dd229c60f8cff78075b6263de1f6b22ba97e5ee94e150c60cded3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.ijo.0802243$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.ijo.0802243$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2725,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14686133$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12629565$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Norman, J.E</creatorcontrib><creatorcontrib>Bild, D</creatorcontrib><creatorcontrib>Lewis, C.E</creatorcontrib><creatorcontrib>Liu, K</creatorcontrib><creatorcontrib>Smith West, D</creatorcontrib><creatorcontrib>CARDIA Study</creatorcontrib><title>impact of weight change on cardiovascular disease risk factors in young black and white adults: the CARDIA study</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes Relat Metab Disord</addtitle><description>OBJECTIVE: To quantify the relation between weight change and change in blood pressure, lipids and insulin levels, and determine if this relation differs by race or initial level of obesity. DESIGN: Longitudinal cohort study. SETTING AND PARTICIPANTS: Community-based sample of 3325 black and white men and women aged 18-30 y from four centers followed for 10 y. Women pregnant at baseline or 10th year exam and persons without a recorded weight at both exams were excluded. Participants whose baseline BMI was >=25 kg/m2 were classified as overweight. Height, weight, HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), fasting triglycerides, fasting insulin, and blood pressure were measured at baseline and Year 10. RESULTS: The mean (s.d.) of weight gained over 10 y was 10.5 (10.0) kg (black men), 11.7 (11.0) (black women), 7.7 (8.0) (white men), and 7.2 (10.0) (white women). An increase in weight was associated with adverse changes in all factors in all race-sex groups. For example, a 9.1 kg (20-lb) weight increase in persons not overweight at baseline predicted an increase in LDL-C ranging from 0.23 mmol/l in black women to 0.28 mmol/l in black men and a decrease in HDL-C from 0.09 mmol/l (white women) to 0.11 mmol/l (white men) (all P<0.0001). The estimated change in triglycerides was greater in white than in black participants (P<0.02); no other racial differences were found. Changes in triglycerides (P<0.00001) and fasting insulin (P=0.004) were greater in men than in women. Only for LDL-C was a weight change-associated increase significantly different (greater, P<0.001) for nonoverweight persons than for those overweight at baseline. None of these associations were highly specific. Mean levels of LDL-C, HDL-C, and systolic blood pressure improved among all those who lost or did not gain weight. CONCLUSIONS: A 10 y weight gain in young adults of both races and sexes tends to confer adverse changes in their levels of LDL-C, HDL-C, triglycerides, fasting insulin, and blood pressure. This effect occurs regardless of initial weight, age, race, or gender.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Analysis. Health state</subject><subject>Biological and medical sciences</subject><subject>Black or African American</subject><subject>Black People</subject><subject>Blacks</subject><subject>Blood Pressure</subject><subject>Body mass index</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - ethnology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cholesterol</subject><subject>Cohort Studies</subject><subject>Epidemiology</subject><subject>fasting</subject><subject>Female</subject><subject>gender</subject><subject>General aspects</subject><subject>Health Promotion and Disease Prevention</subject><subject>Health risks</subject><subject>High density lipoprotein</subject><subject>high density lipoprotein cholesterol</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin - blood</subject><subject>Internal Medicine</subject><subject>Linear Models</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Longitudinal Studies</subject><subject>Low density lipoprotein</subject><subject>low density lipoprotein cholesterol</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>men</subject><subject>Metabolic Diseases</subject><subject>Obesity</subject><subject>Odds Ratio</subject><subject>Overweight</subject><subject>pregnant women</subject><subject>Public Health</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Race</subject><subject>races</subject><subject>Risk Factors</subject><subject>systolic blood pressure</subject><subject>triacylglycerols</subject><subject>Triglycerides</subject><subject>United States - epidemiology</subject><subject>weight gain</subject><subject>Weight Gain - physiology</subject><subject>Weight Loss - physiology</subject><subject>White People</subject><subject>Whites</subject><subject>Women</subject><subject>Young adults</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kcFv0zAUxiMEYmVw5QZYSHBr5zix43CrugGTJiEBO1uO_dy4S-3Odpj63-MpEYUD8sHSe7_ve37-iuJ1iVclrvhF3K3szq8wx4TU1ZNiUdYNW9K6bZ4WC1zhZokpo2fFixh3GGNKMXlenJWEkTbXF8XB7g9SJeQNegC77RNSvXRbQN4hJYO2_peMahxkQNpGkBFQsPEOmSzyISLr0NGPbou6Qao7JJ1GD71NgKQehxQ_odQD2qy_X16vUUyjPr4snhk5RHg13-fF7eern5uvy5tvX64365ulog1OS1bptgXT4U5TrQlpFcOGK2MajhvaMZIBKA3rCOlk2wAFaGsoKc6c0qCr8-L95HsI_n6EmMTOj8HlkYKUbd6-qXmGVhO0lQMI64xPQap8NOyt8g6MzfV1yXlNWc1ZFnz8S9CDHFIf_TAm6138F5ydVfAxBjDiEOxehqMosXhMTsSdyMmJObkseDu_d-z2oE_4HFUGPsxADkQOJkinbDxxNeOsrB6NLiYu5lZOMpwW_-_oN5PCyTQG-GN56r-b-kZ6Ibc5f3H7g-D82Rg3Fedt9RvD98RD</recordid><startdate>20030301</startdate><enddate>20030301</enddate><creator>Norman, J.E</creator><creator>Bild, D</creator><creator>Lewis, C.E</creator><creator>Liu, K</creator><creator>Smith West, D</creator><general>Nature Publishing Group</general><general>Nature Publishing Group UK</general><general>Nature Publishing</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20030301</creationdate><title>impact of weight change on cardiovascular disease risk factors in young black and white adults: the CARDIA study</title><author>Norman, J.E ; Bild, D ; Lewis, C.E ; Liu, K ; Smith West, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c570t-63d99efb0bd5dd229c60f8cff78075b6263de1f6b22ba97e5ee94e150c60cded3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Analysis. Health state</topic><topic>Biological and medical sciences</topic><topic>Black or African American</topic><topic>Black People</topic><topic>Blacks</topic><topic>Blood Pressure</topic><topic>Body mass index</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - ethnology</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cholesterol</topic><topic>Cohort Studies</topic><topic>Epidemiology</topic><topic>fasting</topic><topic>Female</topic><topic>gender</topic><topic>General aspects</topic><topic>Health Promotion and Disease Prevention</topic><topic>Health risks</topic><topic>High density lipoprotein</topic><topic>high density lipoprotein cholesterol</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin - blood</topic><topic>Internal Medicine</topic><topic>Linear Models</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>Longitudinal Studies</topic><topic>Low density lipoprotein</topic><topic>low density lipoprotein cholesterol</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>men</topic><topic>Metabolic Diseases</topic><topic>Obesity</topic><topic>Odds Ratio</topic><topic>Overweight</topic><topic>pregnant women</topic><topic>Public Health</topic><topic>Public health. 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Hygiene-occupational medicine</topic><topic>Race</topic><topic>races</topic><topic>Risk Factors</topic><topic>systolic blood pressure</topic><topic>triacylglycerols</topic><topic>Triglycerides</topic><topic>United States - epidemiology</topic><topic>weight gain</topic><topic>Weight Gain - physiology</topic><topic>Weight Loss - physiology</topic><topic>White People</topic><topic>Whites</topic><topic>Women</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Norman, J.E</creatorcontrib><creatorcontrib>Bild, D</creatorcontrib><creatorcontrib>Lewis, C.E</creatorcontrib><creatorcontrib>Liu, K</creatorcontrib><creatorcontrib>Smith West, D</creatorcontrib><creatorcontrib>CARDIA Study</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Norman, J.E</au><au>Bild, D</au><au>Lewis, C.E</au><au>Liu, K</au><au>Smith West, D</au><aucorp>CARDIA Study</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>impact of weight change on cardiovascular disease risk factors in young black and white adults: the CARDIA study</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes Relat Metab Disord</addtitle><date>2003-03-01</date><risdate>2003</risdate><volume>27</volume><issue>3</issue><spage>369</spage><epage>376</epage><pages>369-376</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><coden>IJOBDP</coden><abstract>OBJECTIVE: To quantify the relation between weight change and change in blood pressure, lipids and insulin levels, and determine if this relation differs by race or initial level of obesity. DESIGN: Longitudinal cohort study. SETTING AND PARTICIPANTS: Community-based sample of 3325 black and white men and women aged 18-30 y from four centers followed for 10 y. Women pregnant at baseline or 10th year exam and persons without a recorded weight at both exams were excluded. Participants whose baseline BMI was >=25 kg/m2 were classified as overweight. Height, weight, HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), fasting triglycerides, fasting insulin, and blood pressure were measured at baseline and Year 10. RESULTS: The mean (s.d.) of weight gained over 10 y was 10.5 (10.0) kg (black men), 11.7 (11.0) (black women), 7.7 (8.0) (white men), and 7.2 (10.0) (white women). An increase in weight was associated with adverse changes in all factors in all race-sex groups. For example, a 9.1 kg (20-lb) weight increase in persons not overweight at baseline predicted an increase in LDL-C ranging from 0.23 mmol/l in black women to 0.28 mmol/l in black men and a decrease in HDL-C from 0.09 mmol/l (white women) to 0.11 mmol/l (white men) (all P<0.0001). The estimated change in triglycerides was greater in white than in black participants (P<0.02); no other racial differences were found. Changes in triglycerides (P<0.00001) and fasting insulin (P=0.004) were greater in men than in women. Only for LDL-C was a weight change-associated increase significantly different (greater, P<0.001) for nonoverweight persons than for those overweight at baseline. None of these associations were highly specific. Mean levels of LDL-C, HDL-C, and systolic blood pressure improved among all those who lost or did not gain weight. CONCLUSIONS: A 10 y weight gain in young adults of both races and sexes tends to confer adverse changes in their levels of LDL-C, HDL-C, triglycerides, fasting insulin, and blood pressure. This effect occurs regardless of initial weight, age, race, or gender.</abstract><cop>London</cop><pub>Nature Publishing Group</pub><pmid>12629565</pmid><doi>10.1038/sj.ijo.0802243</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Analysis. Health state Biological and medical sciences Black or African American Black People Blacks Blood Pressure Body mass index Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - ethnology Cardiovascular Diseases - etiology Cholesterol Cohort Studies Epidemiology fasting Female gender General aspects Health Promotion and Disease Prevention Health risks High density lipoprotein high density lipoprotein cholesterol Humans Insulin Insulin - blood Internal Medicine Linear Models Lipids Lipids - blood Longitudinal Studies Low density lipoprotein low density lipoprotein cholesterol Male Medical sciences Medicine Medicine & Public Health men Metabolic Diseases Obesity Odds Ratio Overweight pregnant women Public Health Public health. Hygiene Public health. Hygiene-occupational medicine Race races Risk Factors systolic blood pressure triacylglycerols Triglycerides United States - epidemiology weight gain Weight Gain - physiology Weight Loss - physiology White People Whites Women Young adults |
| title | impact of weight change on cardiovascular disease risk factors in young black and white adults: the CARDIA study |
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