Relation of waist circumference and glycemic status to C-reactive protein in the Sandy Lake Oji-Cree
OBJECTIVE: To determine the prevalence of elevated C-reactive protein (CRP) in the Sandy Lake Oji-Cree, an aboriginal community residing in the Sioux Lookout zone of Northwestern Ontario, Canada, and to determine the associations of obesity and diabetes with CRP in a community with a very high preva...
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| Veröffentlicht in: | International Journal of Obesity 2003-03, Vol.27 (3), p.347-354 |
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| container_title | International Journal of Obesity |
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| creator | Connelly, P.W Hanley, A.J Harris, S.B Hegele, R.A Zinman, B |
| description | OBJECTIVE: To determine the prevalence of elevated C-reactive protein (CRP) in the Sandy Lake Oji-Cree, an aboriginal community residing in the Sioux Lookout zone of Northwestern Ontario, Canada, and to determine the associations of obesity and diabetes with CRP in a community with a very high prevalence of type II diabetes. DESIGN: We surveyed 512 community members aged 18 y and older to determine the prevalence and the determinants of elevated CRP in Sandy Lake. MEASUREMENTS:Clinical variables, indices of obesity and serum concentrations of CRP, insulin, serum amyloid A (SAA) and interleukin-6 (IL-6). RESULTS: The prevalence of CRP 3.8 mg/l was significantly higher in women than in men (51% vs. 32%, P |
| doi_str_mv | 10.1038/sj.ijo.0802239 |
| format | Article |
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DESIGN: We surveyed 512 community members aged 18 y and older to determine the prevalence and the determinants of elevated CRP in Sandy Lake. MEASUREMENTS:Clinical variables, indices of obesity and serum concentrations of CRP, insulin, serum amyloid A (SAA) and interleukin-6 (IL-6). RESULTS: The prevalence of CRP 3.8 mg/l was significantly higher in women than in men (51% vs. 32%, P<0.0001). Regression analysis determined that body mass index and IL-6 were independent determinants of CRP concentration in women and waist circumference and IL-6 were independent determinants of CRP concentration in men. Diabetes was associated with elevated CRP in both sexes, but was only a moderate strong determinant in CRP concentration in multivariate regression analysis. CONCLUSIONS: The prevalence of elevated CRP in this aboriginal community is remarkably high. These data further demonstrate that the association between CRP and specific indices of obesity and metabolism vary according to gender and glycemic status.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/sj.ijo.0802239</identifier><identifier>PMID: 12629562</identifier><identifier>CODEN: IJOBDP</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing Group</publisher><subject>Adolescent ; Adult ; Aged ; amyloid ; Analysis. Health state ; Biological and medical sciences ; Biomarkers - blood ; Blood Glucose - analysis ; blood serum ; Body Constitution ; Body Mass Index ; C-reactive protein ; C-Reactive Protein - analysis ; Cardiovascular disease ; Child ; Community ; Cross-Sectional Studies ; Cytokines ; Diabetes ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - ethnology ; Diabetes Mellitus, Type 2 - physiopathology ; Epidemiology ; Female ; gender ; General aspects ; Glucose ; Humans ; Immunoassay ; Insulin ; interleukin-6 ; Interleukin-6 - blood ; Lakes ; Lipids ; Male ; Medical sciences ; men ; metabolism ; Middle Aged ; Native North Americans ; noninsulin-dependent diabetes mellitus ; Obesity ; Obesity - blood ; Obesity - ethnology ; Obesity - physiopathology ; Ontario - epidemiology ; Proteins ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Regression Analysis ; Sex Factors ; waist circumference ; Women</subject><ispartof>International Journal of Obesity, 2003-03, Vol.27 (3), p.347-354</ispartof><rights>2003 INIST-CNRS</rights><rights>COPYRIGHT 2003 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c501t-a84b178b40f820febf5607618ae3dd4a0a5a2d02521eaff9653a63668f8301053</citedby><cites>FETCH-LOGICAL-c501t-a84b178b40f820febf5607618ae3dd4a0a5a2d02521eaff9653a63668f8301053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,2728,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14686130$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12629562$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Connelly, P.W</creatorcontrib><creatorcontrib>Hanley, A.J</creatorcontrib><creatorcontrib>Harris, S.B</creatorcontrib><creatorcontrib>Hegele, R.A</creatorcontrib><creatorcontrib>Zinman, B</creatorcontrib><title>Relation of waist circumference and glycemic status to C-reactive protein in the Sandy Lake Oji-Cree</title><title>International Journal of Obesity</title><addtitle>Int J Obes Relat Metab Disord</addtitle><description>OBJECTIVE: To determine the prevalence of elevated C-reactive protein (CRP) in the Sandy Lake Oji-Cree, an aboriginal community residing in the Sioux Lookout zone of Northwestern Ontario, Canada, and to determine the associations of obesity and diabetes with CRP in a community with a very high prevalence of type II diabetes. DESIGN: We surveyed 512 community members aged 18 y and older to determine the prevalence and the determinants of elevated CRP in Sandy Lake. MEASUREMENTS:Clinical variables, indices of obesity and serum concentrations of CRP, insulin, serum amyloid A (SAA) and interleukin-6 (IL-6). RESULTS: The prevalence of CRP 3.8 mg/l was significantly higher in women than in men (51% vs. 32%, P<0.0001). Regression analysis determined that body mass index and IL-6 were independent determinants of CRP concentration in women and waist circumference and IL-6 were independent determinants of CRP concentration in men. Diabetes was associated with elevated CRP in both sexes, but was only a moderate strong determinant in CRP concentration in multivariate regression analysis. CONCLUSIONS: The prevalence of elevated CRP in this aboriginal community is remarkably high. These data further demonstrate that the association between CRP and specific indices of obesity and metabolism vary according to gender and glycemic status.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>amyloid</subject><subject>Analysis. Health state</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood Glucose - analysis</subject><subject>blood serum</subject><subject>Body Constitution</subject><subject>Body Mass Index</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>Cardiovascular disease</subject><subject>Child</subject><subject>Community</subject><subject>Cross-Sectional Studies</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - ethnology</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>gender</subject><subject>General aspects</subject><subject>Glucose</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Insulin</subject><subject>interleukin-6</subject><subject>Interleukin-6 - blood</subject><subject>Lakes</subject><subject>Lipids</subject><subject>Male</subject><subject>Medical sciences</subject><subject>men</subject><subject>metabolism</subject><subject>Middle Aged</subject><subject>Native North Americans</subject><subject>noninsulin-dependent diabetes mellitus</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - ethnology</subject><subject>Obesity - physiopathology</subject><subject>Ontario - epidemiology</subject><subject>Proteins</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Regression Analysis</subject><subject>Sex Factors</subject><subject>waist circumference</subject><subject>Women</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkt-L1DAQx4so3nr66psaFH3rmh9Nmj4ei79g4cDznstsOtlN7TZ3Sarsf2-WLa7CkUBg8vnOZOabonjJ6JJRoT_Gful6v6Saci6aR8WCVbUqZdXUj4sFFbQuqVTyongWY08plZLyp8UF44o3UvFF0X3HAZLzI_GW_AYXEzEumGlvMeBokMDYke1wMLh3hsQEaYokebIqA4JJ7heSu-ATupHknXZIbrLiQNbwE8l178pVQHxePLEwRHwxn5fF7edPP1Zfy_X1l2-rq3VpJGWpBF1tWK03FbWaU4sbKxWtFdOAousqoCCBd5RLzhCsbZQUoIRS2mpBGZXisnh7ypufdD9hTG3vpzDmki1nzbFj1WTo3QnawoCtG61PAczeRdNeMa0rqSotMrV8gMqrOw7Cj2hdjv8n-PCPYIcwpF30w3ScbXwwswk-xoC2vQtuD-HQMtoePW1j32ZP29nTLHg9dzVt9tid8dnEDLyfAYgGBhtgNC6euUppxQTN3KsTN2YXA_4FzoXenO4t-Ba2Iee4veGUyfxxaqG1En8AeaG6Fg</recordid><startdate>20030301</startdate><enddate>20030301</enddate><creator>Connelly, P.W</creator><creator>Hanley, A.J</creator><creator>Harris, S.B</creator><creator>Hegele, R.A</creator><creator>Zinman, B</creator><general>Nature Publishing Group</general><general>Nature Publishing</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20030301</creationdate><title>Relation of waist circumference and glycemic status to C-reactive protein in the Sandy Lake Oji-Cree</title><author>Connelly, P.W ; Hanley, A.J ; Harris, S.B ; Hegele, R.A ; Zinman, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c501t-a84b178b40f820febf5607618ae3dd4a0a5a2d02521eaff9653a63668f8301053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>amyloid</topic><topic>Analysis. Health state</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood Glucose - analysis</topic><topic>blood serum</topic><topic>Body Constitution</topic><topic>Body Mass Index</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>Cardiovascular disease</topic><topic>Child</topic><topic>Community</topic><topic>Cross-Sectional Studies</topic><topic>Cytokines</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - ethnology</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Epidemiology</topic><topic>Female</topic><topic>gender</topic><topic>General aspects</topic><topic>Glucose</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Insulin</topic><topic>interleukin-6</topic><topic>Interleukin-6 - blood</topic><topic>Lakes</topic><topic>Lipids</topic><topic>Male</topic><topic>Medical sciences</topic><topic>men</topic><topic>metabolism</topic><topic>Middle Aged</topic><topic>Native North Americans</topic><topic>noninsulin-dependent diabetes mellitus</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Obesity - ethnology</topic><topic>Obesity - physiopathology</topic><topic>Ontario - epidemiology</topic><topic>Proteins</topic><topic>Public health. 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DESIGN: We surveyed 512 community members aged 18 y and older to determine the prevalence and the determinants of elevated CRP in Sandy Lake. MEASUREMENTS:Clinical variables, indices of obesity and serum concentrations of CRP, insulin, serum amyloid A (SAA) and interleukin-6 (IL-6). RESULTS: The prevalence of CRP 3.8 mg/l was significantly higher in women than in men (51% vs. 32%, P<0.0001). Regression analysis determined that body mass index and IL-6 were independent determinants of CRP concentration in women and waist circumference and IL-6 were independent determinants of CRP concentration in men. Diabetes was associated with elevated CRP in both sexes, but was only a moderate strong determinant in CRP concentration in multivariate regression analysis. CONCLUSIONS: The prevalence of elevated CRP in this aboriginal community is remarkably high. These data further demonstrate that the association between CRP and specific indices of obesity and metabolism vary according to gender and glycemic status.</abstract><cop>Basingstoke</cop><pub>Nature Publishing Group</pub><pmid>12629562</pmid><doi>10.1038/sj.ijo.0802239</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged amyloid Analysis. Health state Biological and medical sciences Biomarkers - blood Blood Glucose - analysis blood serum Body Constitution Body Mass Index C-reactive protein C-Reactive Protein - analysis Cardiovascular disease Child Community Cross-Sectional Studies Cytokines Diabetes Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - ethnology Diabetes Mellitus, Type 2 - physiopathology Epidemiology Female gender General aspects Glucose Humans Immunoassay Insulin interleukin-6 Interleukin-6 - blood Lakes Lipids Male Medical sciences men metabolism Middle Aged Native North Americans noninsulin-dependent diabetes mellitus Obesity Obesity - blood Obesity - ethnology Obesity - physiopathology Ontario - epidemiology Proteins Public health. Hygiene Public health. Hygiene-occupational medicine Regression Analysis Sex Factors waist circumference Women |
| title | Relation of waist circumference and glycemic status to C-reactive protein in the Sandy Lake Oji-Cree |
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