Obesity is an independent risk factor for plasma lipid peroxidation and depletion of erythrocyte cytoprotectic enzymes in humans

OBJECTIVE: Obesity, defined as a body mass index (BMI) greater than 30 kg/m2, is now recognised as a risk factor for diabetes mellitus, hyperlipidaemia, colon cancer, sudden death and other cardiovascular diseases. In this study, it is hypothesized that obesity is an independent risk factor for lipi...

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Veröffentlicht in:International Journal of Obesity 2002-09, Vol.26 (9), p.1159-1164
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description OBJECTIVE: Obesity, defined as a body mass index (BMI) greater than 30 kg/m2, is now recognised as a risk factor for diabetes mellitus, hyperlipidaemia, colon cancer, sudden death and other cardiovascular diseases. In this study, it is hypothesized that obesity is an independent risk factor for lipid peroxidation and decreased activities of cytoprotective enzymes in humans. SUBJECTS: Fifty normal healthy subjects with healthy BMI (19-25 kg/m2) and 250 subjects with different grades of obesity (30-50 kg/m2) with no history of smoking or biochemical evidence of diabetes mellitus, hypertension, hyperlipidaemia, renal or liver disease or cancer. MEASUREMENTS: To test this hypothesis, we assessed lipid peroxidation and cytoprotection by measuring the concentrations of plasma malondialdehyde (P-MDA) and the activities of erythrocyte copper zinc-superoxide dismutase (CuZn-SOD) and glutathione peroxidase (GPX). RESULTS: The concentration of P-MDA was significantly lower (P
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In this study, it is hypothesized that obesity is an independent risk factor for lipid peroxidation and decreased activities of cytoprotective enzymes in humans. SUBJECTS: Fifty normal healthy subjects with healthy BMI (19-25 kg/m2) and 250 subjects with different grades of obesity (30-50 kg/m2) with no history of smoking or biochemical evidence of diabetes mellitus, hypertension, hyperlipidaemia, renal or liver disease or cancer. MEASUREMENTS: To test this hypothesis, we assessed lipid peroxidation and cytoprotection by measuring the concentrations of plasma malondialdehyde (P-MDA) and the activities of erythrocyte copper zinc-superoxide dismutase (CuZn-SOD) and glutathione peroxidase (GPX). RESULTS: The concentration of P-MDA was significantly lower (P&lt;0.001) in subjects with healthy BMI (2.53±0.04 μmol/l) than in those with BMI above 40 kg/m2 (4.75±0.05 μmol/l). Furthermore, there was a significantly positive association (r=0.342, P=0.013) between BMI and P-MDA. On the other hand, subjects with healthy BMI had significantly higher (P&lt;0.001) erythrocyte CUZn-SOD (1464±23 units/g Hb) and GPX (98.4±3.3 units/g Hb) than those with BMI above 40 kg/m2 (1005±26 units/g Hb) and (84.3+6.7 units/g Hb) respectively. Furthermore, erythrocyte CuZn-SOD and GPX activities were negatively associated with BMI (r=-0.566, P=0.005 and r=-0.436, P=0.018) respectively. CONCLUSION: It is concluded from these results that obesity in the absence of smoking, diabetes mellitus, hyperlipidaemia, renal or liver disease causes lipid peroxidation and decreased activities of cytoprotective enzymes, and should therefore receive the same attention as obesity with complications.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/sj.ijo.0802066</identifier><identifier>PMID: 12187391</identifier><identifier>CODEN: IJOBDP</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing Group</publisher><subject>Adult ; Analysis of Variance ; Analysis. Health state ; Biological and medical sciences ; Blood Glucose - analysis ; blood lipids ; Body Mass Index ; Cardiovascular diseases ; Cholesterol - blood ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; colorectal neoplasms ; Copper ; Creatinine - blood ; Cytoprotection - physiology ; death ; Diabetes ; diabetes mellitus ; Enzymes ; Epidemiology ; Erythrocytes ; Erythrocytes - enzymology ; Female ; General aspects ; glutathione peroxidase ; Glutathione Peroxidase - blood ; Humans ; hyperlipidemia ; Hypertension ; Hypotheses ; Lipid peroxidation ; Lipid Peroxidation - physiology ; Lipids ; liver ; Liver diseases ; Male ; malondialdehyde ; Malondialdehyde - blood ; Medical sciences ; Metabolic diseases ; Obesity ; Obesity - metabolism ; Overweight ; Peroxidation ; Plasma ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Factors ; Superoxide Dismutase - blood ; Triglycerides - blood</subject><ispartof>International Journal of Obesity, 2002-09, Vol.26 (9), p.1159-1164</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Sep 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-635668660164f554c54f263eee27e37fb0c6dbd5fc9c8421ff70406aa3ee4d933</citedby><cites>FETCH-LOGICAL-c407t-635668660164f554c54f263eee27e37fb0c6dbd5fc9c8421ff70406aa3ee4d933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=13899026$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12187391$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Olusi, S.O</creatorcontrib><title>Obesity is an independent risk factor for plasma lipid peroxidation and depletion of erythrocyte cytoprotectic enzymes in humans</title><title>International Journal of Obesity</title><addtitle>Int J Obes Relat Metab Disord</addtitle><description>OBJECTIVE: Obesity, defined as a body mass index (BMI) greater than 30 kg/m2, is now recognised as a risk factor for diabetes mellitus, hyperlipidaemia, colon cancer, sudden death and other cardiovascular diseases. In this study, it is hypothesized that obesity is an independent risk factor for lipid peroxidation and decreased activities of cytoprotective enzymes in humans. SUBJECTS: Fifty normal healthy subjects with healthy BMI (19-25 kg/m2) and 250 subjects with different grades of obesity (30-50 kg/m2) with no history of smoking or biochemical evidence of diabetes mellitus, hypertension, hyperlipidaemia, renal or liver disease or cancer. MEASUREMENTS: To test this hypothesis, we assessed lipid peroxidation and cytoprotection by measuring the concentrations of plasma malondialdehyde (P-MDA) and the activities of erythrocyte copper zinc-superoxide dismutase (CuZn-SOD) and glutathione peroxidase (GPX). RESULTS: The concentration of P-MDA was significantly lower (P&lt;0.001) in subjects with healthy BMI (2.53±0.04 μmol/l) than in those with BMI above 40 kg/m2 (4.75±0.05 μmol/l). Furthermore, there was a significantly positive association (r=0.342, P=0.013) between BMI and P-MDA. On the other hand, subjects with healthy BMI had significantly higher (P&lt;0.001) erythrocyte CUZn-SOD (1464±23 units/g Hb) and GPX (98.4±3.3 units/g Hb) than those with BMI above 40 kg/m2 (1005±26 units/g Hb) and (84.3+6.7 units/g Hb) respectively. Furthermore, erythrocyte CuZn-SOD and GPX activities were negatively associated with BMI (r=-0.566, P=0.005 and r=-0.436, P=0.018) respectively. CONCLUSION: It is concluded from these results that obesity in the absence of smoking, diabetes mellitus, hyperlipidaemia, renal or liver disease causes lipid peroxidation and decreased activities of cytoprotective enzymes, and should therefore receive the same attention as obesity with complications.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Analysis. Health state</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>blood lipids</subject><subject>Body Mass Index</subject><subject>Cardiovascular diseases</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>colorectal neoplasms</subject><subject>Copper</subject><subject>Creatinine - blood</subject><subject>Cytoprotection - physiology</subject><subject>death</subject><subject>Diabetes</subject><subject>diabetes mellitus</subject><subject>Enzymes</subject><subject>Epidemiology</subject><subject>Erythrocytes</subject><subject>Erythrocytes - enzymology</subject><subject>Female</subject><subject>General aspects</subject><subject>glutathione peroxidase</subject><subject>Glutathione Peroxidase - blood</subject><subject>Humans</subject><subject>hyperlipidemia</subject><subject>Hypertension</subject><subject>Hypotheses</subject><subject>Lipid peroxidation</subject><subject>Lipid Peroxidation - physiology</subject><subject>Lipids</subject><subject>liver</subject><subject>Liver diseases</subject><subject>Male</subject><subject>malondialdehyde</subject><subject>Malondialdehyde - blood</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Obesity</subject><subject>Obesity - metabolism</subject><subject>Overweight</subject><subject>Peroxidation</subject><subject>Plasma</subject><subject>Public health. Hygiene</subject><subject>Public health. 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Health state</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>blood lipids</topic><topic>Body Mass Index</topic><topic>Cardiovascular diseases</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>colorectal neoplasms</topic><topic>Copper</topic><topic>Creatinine - blood</topic><topic>Cytoprotection - physiology</topic><topic>death</topic><topic>Diabetes</topic><topic>diabetes mellitus</topic><topic>Enzymes</topic><topic>Epidemiology</topic><topic>Erythrocytes</topic><topic>Erythrocytes - enzymology</topic><topic>Female</topic><topic>General aspects</topic><topic>glutathione peroxidase</topic><topic>Glutathione Peroxidase - blood</topic><topic>Humans</topic><topic>hyperlipidemia</topic><topic>Hypertension</topic><topic>Hypotheses</topic><topic>Lipid peroxidation</topic><topic>Lipid Peroxidation - physiology</topic><topic>Lipids</topic><topic>liver</topic><topic>Liver diseases</topic><topic>Male</topic><topic>malondialdehyde</topic><topic>Malondialdehyde - blood</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Obesity</topic><topic>Obesity - metabolism</topic><topic>Overweight</topic><topic>Peroxidation</topic><topic>Plasma</topic><topic>Public health. 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Hygiene-occupational medicine</topic><topic>Risk Factors</topic><topic>Superoxide Dismutase - blood</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Olusi, S.O</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olusi, S.O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obesity is an independent risk factor for plasma lipid peroxidation and depletion of erythrocyte cytoprotectic enzymes in humans</atitle><jtitle>International Journal of Obesity</jtitle><addtitle>Int J Obes Relat Metab Disord</addtitle><date>2002-09-01</date><risdate>2002</risdate><volume>26</volume><issue>9</issue><spage>1159</spage><epage>1164</epage><pages>1159-1164</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><coden>IJOBDP</coden><abstract>OBJECTIVE: Obesity, defined as a body mass index (BMI) greater than 30 kg/m2, is now recognised as a risk factor for diabetes mellitus, hyperlipidaemia, colon cancer, sudden death and other cardiovascular diseases. In this study, it is hypothesized that obesity is an independent risk factor for lipid peroxidation and decreased activities of cytoprotective enzymes in humans. SUBJECTS: Fifty normal healthy subjects with healthy BMI (19-25 kg/m2) and 250 subjects with different grades of obesity (30-50 kg/m2) with no history of smoking or biochemical evidence of diabetes mellitus, hypertension, hyperlipidaemia, renal or liver disease or cancer. MEASUREMENTS: To test this hypothesis, we assessed lipid peroxidation and cytoprotection by measuring the concentrations of plasma malondialdehyde (P-MDA) and the activities of erythrocyte copper zinc-superoxide dismutase (CuZn-SOD) and glutathione peroxidase (GPX). RESULTS: The concentration of P-MDA was significantly lower (P&lt;0.001) in subjects with healthy BMI (2.53±0.04 μmol/l) than in those with BMI above 40 kg/m2 (4.75±0.05 μmol/l). Furthermore, there was a significantly positive association (r=0.342, P=0.013) between BMI and P-MDA. On the other hand, subjects with healthy BMI had significantly higher (P&lt;0.001) erythrocyte CUZn-SOD (1464±23 units/g Hb) and GPX (98.4±3.3 units/g Hb) than those with BMI above 40 kg/m2 (1005±26 units/g Hb) and (84.3+6.7 units/g Hb) respectively. Furthermore, erythrocyte CuZn-SOD and GPX activities were negatively associated with BMI (r=-0.566, P=0.005 and r=-0.436, P=0.018) respectively. CONCLUSION: It is concluded from these results that obesity in the absence of smoking, diabetes mellitus, hyperlipidaemia, renal or liver disease causes lipid peroxidation and decreased activities of cytoprotective enzymes, and should therefore receive the same attention as obesity with complications.</abstract><cop>Basingstoke</cop><pub>Nature Publishing Group</pub><pmid>12187391</pmid><doi>10.1038/sj.ijo.0802066</doi><tpages>6</tpages></addata></record>
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source MEDLINE; Nature; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerLink Journals - AutoHoldings
subjects Adult
Analysis of Variance
Analysis. Health state
Biological and medical sciences
Blood Glucose - analysis
blood lipids
Body Mass Index
Cardiovascular diseases
Cholesterol - blood
Cholesterol, HDL - blood
Cholesterol, LDL - blood
colorectal neoplasms
Copper
Creatinine - blood
Cytoprotection - physiology
death
Diabetes
diabetes mellitus
Enzymes
Epidemiology
Erythrocytes
Erythrocytes - enzymology
Female
General aspects
glutathione peroxidase
Glutathione Peroxidase - blood
Humans
hyperlipidemia
Hypertension
Hypotheses
Lipid peroxidation
Lipid Peroxidation - physiology
Lipids
liver
Liver diseases
Male
malondialdehyde
Malondialdehyde - blood
Medical sciences
Metabolic diseases
Obesity
Obesity - metabolism
Overweight
Peroxidation
Plasma
Public health. Hygiene
Public health. Hygiene-occupational medicine
Risk Factors
Superoxide Dismutase - blood
Triglycerides - blood
title Obesity is an independent risk factor for plasma lipid peroxidation and depletion of erythrocyte cytoprotectic enzymes in humans
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