Obesity is an independent risk factor for plasma lipid peroxidation and depletion of erythrocyte cytoprotectic enzymes in humans
OBJECTIVE: Obesity, defined as a body mass index (BMI) greater than 30 kg/m2, is now recognised as a risk factor for diabetes mellitus, hyperlipidaemia, colon cancer, sudden death and other cardiovascular diseases. In this study, it is hypothesized that obesity is an independent risk factor for lipi...
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description | OBJECTIVE: Obesity, defined as a body mass index (BMI) greater than 30 kg/m2, is now recognised as a risk factor for diabetes mellitus, hyperlipidaemia, colon cancer, sudden death and other cardiovascular diseases. In this study, it is hypothesized that obesity is an independent risk factor for lipid peroxidation and decreased activities of cytoprotective enzymes in humans. SUBJECTS: Fifty normal healthy subjects with healthy BMI (19-25 kg/m2) and 250 subjects with different grades of obesity (30-50 kg/m2) with no history of smoking or biochemical evidence of diabetes mellitus, hypertension, hyperlipidaemia, renal or liver disease or cancer. MEASUREMENTS: To test this hypothesis, we assessed lipid peroxidation and cytoprotection by measuring the concentrations of plasma malondialdehyde (P-MDA) and the activities of erythrocyte copper zinc-superoxide dismutase (CuZn-SOD) and glutathione peroxidase (GPX). RESULTS: The concentration of P-MDA was significantly lower (P |
doi_str_mv | 10.1038/sj.ijo.0802066 |
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In this study, it is hypothesized that obesity is an independent risk factor for lipid peroxidation and decreased activities of cytoprotective enzymes in humans. SUBJECTS: Fifty normal healthy subjects with healthy BMI (19-25 kg/m2) and 250 subjects with different grades of obesity (30-50 kg/m2) with no history of smoking or biochemical evidence of diabetes mellitus, hypertension, hyperlipidaemia, renal or liver disease or cancer. MEASUREMENTS: To test this hypothesis, we assessed lipid peroxidation and cytoprotection by measuring the concentrations of plasma malondialdehyde (P-MDA) and the activities of erythrocyte copper zinc-superoxide dismutase (CuZn-SOD) and glutathione peroxidase (GPX). RESULTS: The concentration of P-MDA was significantly lower (P<0.001) in subjects with healthy BMI (2.53±0.04 μmol/l) than in those with BMI above 40 kg/m2 (4.75±0.05 μmol/l). Furthermore, there was a significantly positive association (r=0.342, P=0.013) between BMI and P-MDA. On the other hand, subjects with healthy BMI had significantly higher (P<0.001) erythrocyte CUZn-SOD (1464±23 units/g Hb) and GPX (98.4±3.3 units/g Hb) than those with BMI above 40 kg/m2 (1005±26 units/g Hb) and (84.3+6.7 units/g Hb) respectively. Furthermore, erythrocyte CuZn-SOD and GPX activities were negatively associated with BMI (r=-0.566, P=0.005 and r=-0.436, P=0.018) respectively. CONCLUSION: It is concluded from these results that obesity in the absence of smoking, diabetes mellitus, hyperlipidaemia, renal or liver disease causes lipid peroxidation and decreased activities of cytoprotective enzymes, and should therefore receive the same attention as obesity with complications.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/sj.ijo.0802066</identifier><identifier>PMID: 12187391</identifier><identifier>CODEN: IJOBDP</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing Group</publisher><subject>Adult ; Analysis of Variance ; Analysis. Health state ; Biological and medical sciences ; Blood Glucose - analysis ; blood lipids ; Body Mass Index ; Cardiovascular diseases ; Cholesterol - blood ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; colorectal neoplasms ; Copper ; Creatinine - blood ; Cytoprotection - physiology ; death ; Diabetes ; diabetes mellitus ; Enzymes ; Epidemiology ; Erythrocytes ; Erythrocytes - enzymology ; Female ; General aspects ; glutathione peroxidase ; Glutathione Peroxidase - blood ; Humans ; hyperlipidemia ; Hypertension ; Hypotheses ; Lipid peroxidation ; Lipid Peroxidation - physiology ; Lipids ; liver ; Liver diseases ; Male ; malondialdehyde ; Malondialdehyde - blood ; Medical sciences ; Metabolic diseases ; Obesity ; Obesity - metabolism ; Overweight ; Peroxidation ; Plasma ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Factors ; Superoxide Dismutase - blood ; Triglycerides - blood</subject><ispartof>International Journal of Obesity, 2002-09, Vol.26 (9), p.1159-1164</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Sep 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-635668660164f554c54f263eee27e37fb0c6dbd5fc9c8421ff70406aa3ee4d933</citedby><cites>FETCH-LOGICAL-c407t-635668660164f554c54f263eee27e37fb0c6dbd5fc9c8421ff70406aa3ee4d933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13899026$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12187391$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Olusi, S.O</creatorcontrib><title>Obesity is an independent risk factor for plasma lipid peroxidation and depletion of erythrocyte cytoprotectic enzymes in humans</title><title>International Journal of Obesity</title><addtitle>Int J Obes Relat Metab Disord</addtitle><description>OBJECTIVE: Obesity, defined as a body mass index (BMI) greater than 30 kg/m2, is now recognised as a risk factor for diabetes mellitus, hyperlipidaemia, colon cancer, sudden death and other cardiovascular diseases. In this study, it is hypothesized that obesity is an independent risk factor for lipid peroxidation and decreased activities of cytoprotective enzymes in humans. SUBJECTS: Fifty normal healthy subjects with healthy BMI (19-25 kg/m2) and 250 subjects with different grades of obesity (30-50 kg/m2) with no history of smoking or biochemical evidence of diabetes mellitus, hypertension, hyperlipidaemia, renal or liver disease or cancer. MEASUREMENTS: To test this hypothesis, we assessed lipid peroxidation and cytoprotection by measuring the concentrations of plasma malondialdehyde (P-MDA) and the activities of erythrocyte copper zinc-superoxide dismutase (CuZn-SOD) and glutathione peroxidase (GPX). RESULTS: The concentration of P-MDA was significantly lower (P<0.001) in subjects with healthy BMI (2.53±0.04 μmol/l) than in those with BMI above 40 kg/m2 (4.75±0.05 μmol/l). Furthermore, there was a significantly positive association (r=0.342, P=0.013) between BMI and P-MDA. On the other hand, subjects with healthy BMI had significantly higher (P<0.001) erythrocyte CUZn-SOD (1464±23 units/g Hb) and GPX (98.4±3.3 units/g Hb) than those with BMI above 40 kg/m2 (1005±26 units/g Hb) and (84.3+6.7 units/g Hb) respectively. Furthermore, erythrocyte CuZn-SOD and GPX activities were negatively associated with BMI (r=-0.566, P=0.005 and r=-0.436, P=0.018) respectively. CONCLUSION: It is concluded from these results that obesity in the absence of smoking, diabetes mellitus, hyperlipidaemia, renal or liver disease causes lipid peroxidation and decreased activities of cytoprotective enzymes, and should therefore receive the same attention as obesity with complications.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Analysis. Health state</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>blood lipids</subject><subject>Body Mass Index</subject><subject>Cardiovascular diseases</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>colorectal neoplasms</subject><subject>Copper</subject><subject>Creatinine - blood</subject><subject>Cytoprotection - physiology</subject><subject>death</subject><subject>Diabetes</subject><subject>diabetes mellitus</subject><subject>Enzymes</subject><subject>Epidemiology</subject><subject>Erythrocytes</subject><subject>Erythrocytes - enzymology</subject><subject>Female</subject><subject>General aspects</subject><subject>glutathione peroxidase</subject><subject>Glutathione Peroxidase - blood</subject><subject>Humans</subject><subject>hyperlipidemia</subject><subject>Hypertension</subject><subject>Hypotheses</subject><subject>Lipid peroxidation</subject><subject>Lipid Peroxidation - physiology</subject><subject>Lipids</subject><subject>liver</subject><subject>Liver diseases</subject><subject>Male</subject><subject>malondialdehyde</subject><subject>Malondialdehyde - blood</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Obesity</subject><subject>Obesity - metabolism</subject><subject>Overweight</subject><subject>Peroxidation</subject><subject>Plasma</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk Factors</subject><subject>Superoxide Dismutase - blood</subject><subject>Triglycerides - blood</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpFkc1r3DAQxUVpabZprz22otCjt6Nv-1hCvyCQQ5Kz0MpSI9e2XEkLcU7506t0DTnMDILfezM8IfSewJ4Aa7_kYR-GuIcWKEj5Au0IV7IRvFMv0Q4YqAaEFGfoTc4DAAgB9DU6I5S0inVkhx6vDi6HsuKQsZlxmHu3uNrmglPIf7A3tsSEfa1lNHkyeAxL6PHiUrwPvSkhzlXY46ob3f9X9NiltdylaNficG1xSbE4W4LFbn5YJ5frInx3nMyc36JX3ozZvdvmObr9_u3m4mdzefXj18XXy8ZyUKWRTEjZSglEci8Et4J7KplzjirHlD-Alf2hF952tuWUeK-AgzSmIrzvGDtHn06-9Za_R5eLHuIxzXWlpqSjinDSVWh_gmyKOSfn9ZLCZNKqCeinvHUedM1bb3lXwYfN9XiYXP-MbwFX4PMGmGzN6JOZbcjPHGu7DuiT0ccT503U5nfNXt9eUyCifppiSlD2D3YelQs</recordid><startdate>20020901</startdate><enddate>20020901</enddate><creator>Olusi, S.O</creator><general>Nature Publishing Group</general><general>Nature Publishing</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20020901</creationdate><title>Obesity is an independent risk factor for plasma lipid peroxidation and depletion of erythrocyte cytoprotectic enzymes in humans</title><author>Olusi, S.O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-635668660164f554c54f263eee27e37fb0c6dbd5fc9c8421ff70406aa3ee4d933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Analysis. Health state</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>blood lipids</topic><topic>Body Mass Index</topic><topic>Cardiovascular diseases</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>colorectal neoplasms</topic><topic>Copper</topic><topic>Creatinine - blood</topic><topic>Cytoprotection - physiology</topic><topic>death</topic><topic>Diabetes</topic><topic>diabetes mellitus</topic><topic>Enzymes</topic><topic>Epidemiology</topic><topic>Erythrocytes</topic><topic>Erythrocytes - enzymology</topic><topic>Female</topic><topic>General aspects</topic><topic>glutathione peroxidase</topic><topic>Glutathione Peroxidase - blood</topic><topic>Humans</topic><topic>hyperlipidemia</topic><topic>Hypertension</topic><topic>Hypotheses</topic><topic>Lipid peroxidation</topic><topic>Lipid Peroxidation - physiology</topic><topic>Lipids</topic><topic>liver</topic><topic>Liver diseases</topic><topic>Male</topic><topic>malondialdehyde</topic><topic>Malondialdehyde - blood</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Obesity</topic><topic>Obesity - metabolism</topic><topic>Overweight</topic><topic>Peroxidation</topic><topic>Plasma</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Risk Factors</topic><topic>Superoxide Dismutase - blood</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Olusi, S.O</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olusi, S.O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obesity is an independent risk factor for plasma lipid peroxidation and depletion of erythrocyte cytoprotectic enzymes in humans</atitle><jtitle>International Journal of Obesity</jtitle><addtitle>Int J Obes Relat Metab Disord</addtitle><date>2002-09-01</date><risdate>2002</risdate><volume>26</volume><issue>9</issue><spage>1159</spage><epage>1164</epage><pages>1159-1164</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><coden>IJOBDP</coden><abstract>OBJECTIVE: Obesity, defined as a body mass index (BMI) greater than 30 kg/m2, is now recognised as a risk factor for diabetes mellitus, hyperlipidaemia, colon cancer, sudden death and other cardiovascular diseases. In this study, it is hypothesized that obesity is an independent risk factor for lipid peroxidation and decreased activities of cytoprotective enzymes in humans. SUBJECTS: Fifty normal healthy subjects with healthy BMI (19-25 kg/m2) and 250 subjects with different grades of obesity (30-50 kg/m2) with no history of smoking or biochemical evidence of diabetes mellitus, hypertension, hyperlipidaemia, renal or liver disease or cancer. MEASUREMENTS: To test this hypothesis, we assessed lipid peroxidation and cytoprotection by measuring the concentrations of plasma malondialdehyde (P-MDA) and the activities of erythrocyte copper zinc-superoxide dismutase (CuZn-SOD) and glutathione peroxidase (GPX). RESULTS: The concentration of P-MDA was significantly lower (P<0.001) in subjects with healthy BMI (2.53±0.04 μmol/l) than in those with BMI above 40 kg/m2 (4.75±0.05 μmol/l). Furthermore, there was a significantly positive association (r=0.342, P=0.013) between BMI and P-MDA. On the other hand, subjects with healthy BMI had significantly higher (P<0.001) erythrocyte CUZn-SOD (1464±23 units/g Hb) and GPX (98.4±3.3 units/g Hb) than those with BMI above 40 kg/m2 (1005±26 units/g Hb) and (84.3+6.7 units/g Hb) respectively. Furthermore, erythrocyte CuZn-SOD and GPX activities were negatively associated with BMI (r=-0.566, P=0.005 and r=-0.436, P=0.018) respectively. CONCLUSION: It is concluded from these results that obesity in the absence of smoking, diabetes mellitus, hyperlipidaemia, renal or liver disease causes lipid peroxidation and decreased activities of cytoprotective enzymes, and should therefore receive the same attention as obesity with complications.</abstract><cop>Basingstoke</cop><pub>Nature Publishing Group</pub><pmid>12187391</pmid><doi>10.1038/sj.ijo.0802066</doi><tpages>6</tpages></addata></record> |
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subjects | Adult Analysis of Variance Analysis. Health state Biological and medical sciences Blood Glucose - analysis blood lipids Body Mass Index Cardiovascular diseases Cholesterol - blood Cholesterol, HDL - blood Cholesterol, LDL - blood colorectal neoplasms Copper Creatinine - blood Cytoprotection - physiology death Diabetes diabetes mellitus Enzymes Epidemiology Erythrocytes Erythrocytes - enzymology Female General aspects glutathione peroxidase Glutathione Peroxidase - blood Humans hyperlipidemia Hypertension Hypotheses Lipid peroxidation Lipid Peroxidation - physiology Lipids liver Liver diseases Male malondialdehyde Malondialdehyde - blood Medical sciences Metabolic diseases Obesity Obesity - metabolism Overweight Peroxidation Plasma Public health. Hygiene Public health. Hygiene-occupational medicine Risk Factors Superoxide Dismutase - blood Triglycerides - blood |
title | Obesity is an independent risk factor for plasma lipid peroxidation and depletion of erythrocyte cytoprotectic enzymes in humans |
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