[beta]-Adrenergic regulation of proinflammatory cytokines in humans
Objectives: To investigate the effects of [beta]-adrenergic stimulation on IL-6 secretion in humans, and to determine the potential contribution to this response of adipocytes and peripheral blood cells (PBC). Design: Experimental study in 8 human volunteers, and in vitro studies on murine adipocyte...
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| Veröffentlicht in: | International Journal of Obesity and Related Disorders 2000-06, Vol.24 (S2), p.S154 |
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| container_title | International Journal of Obesity and Related Disorders |
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| creator | Mohamed-Ali, V Bulmer, K Clarke, D Goodrick, S Coppack, S W Pinkney, J H |
| description | Objectives: To investigate the effects of [beta]-adrenergic stimulation on IL-6 secretion in humans, and to determine the potential contribution to this response of adipocytes and peripheral blood cells (PBC). Design: Experimental study in 8 human volunteers, and in vitro studies on murine adipocyte cell-line, 3T3.L1 and 3T3.F442A, and human PBC. Measurements: Plasma IL-6 and TNF[alpha] responses to isoprenaline infusion. Cytokine secretion from differentiated adipocyte cell-lines and PBC in response to isoprenaline. Results: Plasma IL-6 levels increased ninefold (median) by 180 min (baseline median 0.51 [interquartile range 0.47-1.4] vs 180 mins 4.53 [2.58-5.69] pg ml-1 , P=0.01). One hour after infusion, IL-6 levels (2.9 [1.27-3.98]) were lower than at 180 min (P=0.05), but higher than baseline (P=0.01). TNF[alpha] levels were unchanged. Differentiated adipocytes incubated in isoprenaline (0-0.1 μM) released significantly increased amounts of IL-6 whereas no response was elicited from PBC. Conclusions: The induction of IL-6 observed in vivo may be attributed to the [beta]-adrenergic stimulation of IL-6 release specifically from adipocytes, as opposed to circulating blood cells. INTERNATIONAL JOURNAL OF OBESITY: (2000) 24, Suppl 2, S154-S155 |
| doi_str_mv | 10.1038/sj.ijo.0801311 |
| format | Article |
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Design: Experimental study in 8 human volunteers, and in vitro studies on murine adipocyte cell-line, 3T3.L1 and 3T3.F442A, and human PBC. Measurements: Plasma IL-6 and TNF[alpha] responses to isoprenaline infusion. Cytokine secretion from differentiated adipocyte cell-lines and PBC in response to isoprenaline. Results: Plasma IL-6 levels increased ninefold (median) by 180 min (baseline median 0.51 [interquartile range 0.47-1.4] vs 180 mins 4.53 [2.58-5.69] pg ml-1 , P=0.01). One hour after infusion, IL-6 levels (2.9 [1.27-3.98]) were lower than at 180 min (P=0.05), but higher than baseline (P=0.01). TNF[alpha] levels were unchanged. Differentiated adipocytes incubated in isoprenaline (0-0.1 μM) released significantly increased amounts of IL-6 whereas no response was elicited from PBC. Conclusions: The induction of IL-6 observed in vivo may be attributed to the [beta]-adrenergic stimulation of IL-6 release specifically from adipocytes, as opposed to circulating blood cells. INTERNATIONAL JOURNAL OF OBESITY: (2000) 24, Suppl 2, S154-S155</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/sj.ijo.0801311</identifier><language>eng</language><publisher>Hampshire: Nature Publishing Group</publisher><subject>Adipocytes ; Body fat ; Cytokines ; Estrogens ; Heart rate ; Medicine ; Obesity ; Plasma</subject><ispartof>International Journal of Obesity and Related Disorders, 2000-06, Vol.24 (S2), p.S154</ispartof><rights>Copyright Nature Publishing Group Jun 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Mohamed-Ali, V</creatorcontrib><creatorcontrib>Bulmer, K</creatorcontrib><creatorcontrib>Clarke, D</creatorcontrib><creatorcontrib>Goodrick, S</creatorcontrib><creatorcontrib>Coppack, S W</creatorcontrib><creatorcontrib>Pinkney, J H</creatorcontrib><title>[beta]-Adrenergic regulation of proinflammatory cytokines in humans</title><title>International Journal of Obesity and Related Disorders</title><description>Objectives: To investigate the effects of [beta]-adrenergic stimulation on IL-6 secretion in humans, and to determine the potential contribution to this response of adipocytes and peripheral blood cells (PBC). Design: Experimental study in 8 human volunteers, and in vitro studies on murine adipocyte cell-line, 3T3.L1 and 3T3.F442A, and human PBC. Measurements: Plasma IL-6 and TNF[alpha] responses to isoprenaline infusion. Cytokine secretion from differentiated adipocyte cell-lines and PBC in response to isoprenaline. Results: Plasma IL-6 levels increased ninefold (median) by 180 min (baseline median 0.51 [interquartile range 0.47-1.4] vs 180 mins 4.53 [2.58-5.69] pg ml-1 , P=0.01). One hour after infusion, IL-6 levels (2.9 [1.27-3.98]) were lower than at 180 min (P=0.05), but higher than baseline (P=0.01). TNF[alpha] levels were unchanged. Differentiated adipocytes incubated in isoprenaline (0-0.1 μM) released significantly increased amounts of IL-6 whereas no response was elicited from PBC. Conclusions: The induction of IL-6 observed in vivo may be attributed to the [beta]-adrenergic stimulation of IL-6 release specifically from adipocytes, as opposed to circulating blood cells. 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Design: Experimental study in 8 human volunteers, and in vitro studies on murine adipocyte cell-line, 3T3.L1 and 3T3.F442A, and human PBC. Measurements: Plasma IL-6 and TNF[alpha] responses to isoprenaline infusion. Cytokine secretion from differentiated adipocyte cell-lines and PBC in response to isoprenaline. Results: Plasma IL-6 levels increased ninefold (median) by 180 min (baseline median 0.51 [interquartile range 0.47-1.4] vs 180 mins 4.53 [2.58-5.69] pg ml-1 , P=0.01). One hour after infusion, IL-6 levels (2.9 [1.27-3.98]) were lower than at 180 min (P=0.05), but higher than baseline (P=0.01). TNF[alpha] levels were unchanged. Differentiated adipocytes incubated in isoprenaline (0-0.1 μM) released significantly increased amounts of IL-6 whereas no response was elicited from PBC. Conclusions: The induction of IL-6 observed in vivo may be attributed to the [beta]-adrenergic stimulation of IL-6 release specifically from adipocytes, as opposed to circulating blood cells. 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| ispartof | International Journal of Obesity and Related Disorders, 2000-06, Vol.24 (S2), p.S154 |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | Adipocytes Body fat Cytokines Estrogens Heart rate Medicine Obesity Plasma |
| title | [beta]-Adrenergic regulation of proinflammatory cytokines in humans |
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