The Role of Nuclear Medicine in the Prediction and Detection of Radiation-Associated Normal Pulmonary and Cardiac Damage
Dose-effect calculations used in the planning of modern radiotherapy (RT) involving normal lung or cardiac tissue rely on structural imaging techniques, such as CT, as the basis for measuring and predicting dose-response. However, more accurate methods for predicting dose-response may result if info...
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| Veröffentlicht in: | The Journal of nuclear medicine (1978) 2003-09, Vol.44 (9), p.1531-1539 |
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| container_title | The Journal of nuclear medicine (1978) |
| container_volume | 44 |
| creator | Goethals, Ingeborg Dierckx, Rudi De Meerleer, Gert De Sutter, Johan De Winter, Olivier De Neve, Wilfried Van de Wiele, Christophe |
| description | Dose-effect calculations used in the planning of modern radiotherapy (RT) involving normal lung or cardiac tissue rely on structural imaging techniques, such as CT, as the basis for measuring and predicting dose-response. However, more accurate methods for predicting dose-response may result if information on the locoregional functional status of the irradiated organ(s) is included in the computational model. For RT cases that involve delivering dose to the lung and heart, this may be achieved by the assessment of tomographic scintigraphies of lung perfusion (Q) and ventilation (V) and scintigraphic imaging of myocardial perfusion and function, respectively. |
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However, more accurate methods for predicting dose-response may result if information on the locoregional functional status of the irradiated organ(s) is included in the computational model. For RT cases that involve delivering dose to the lung and heart, this may be achieved by the assessment of tomographic scintigraphies of lung perfusion (Q) and ventilation (V) and scintigraphic imaging of myocardial perfusion and function, respectively.</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><identifier>PMID: 12960203</identifier><identifier>CODEN: JNMEAQ</identifier><language>eng</language><publisher>Reston, VA: Soc Nuclear Med</publisher><subject>Biological and medical sciences ; Breast Neoplasms - radiotherapy ; Cardiomyopathies - diagnostic imaging ; Cardiomyopathies - etiology ; Cardiomyopathies - mortality ; Cardiomyopathies - prevention & control ; Dose-Response Relationship, Radiation ; Heart - radiation effects ; Hodgkin Disease - radiotherapy ; Humans ; Lung - radiation effects ; Lymphoma - radiotherapy ; Medical sciences ; Radiation Injuries - diagnostic imaging ; Radiation Injuries - etiology ; Radiation Injuries - mortality ; Radiation Injuries - prevention & control ; Radiation Pneumonitis - diagnostic imaging ; Radiation Pneumonitis - etiology ; Radiation Pneumonitis - mortality ; Radiation Pneumonitis - prevention & control ; Radiation Protection - methods ; Radiometry - methods ; Radionuclide Imaging ; Radiotherapy - adverse effects ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted - methods ; Risk Assessment - methods</subject><ispartof>The Journal of nuclear medicine (1978), 2003-09, Vol.44 (9), p.1531-1539</ispartof><rights>2003 INIST-CNRS</rights><rights>Copyright Society of Nuclear Medicine Sep 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15128641$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12960203$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goethals, Ingeborg</creatorcontrib><creatorcontrib>Dierckx, Rudi</creatorcontrib><creatorcontrib>De Meerleer, Gert</creatorcontrib><creatorcontrib>De Sutter, Johan</creatorcontrib><creatorcontrib>De Winter, Olivier</creatorcontrib><creatorcontrib>De Neve, Wilfried</creatorcontrib><creatorcontrib>Van de Wiele, Christophe</creatorcontrib><title>The Role of Nuclear Medicine in the Prediction and Detection of Radiation-Associated Normal Pulmonary and Cardiac Damage</title><title>The Journal of nuclear medicine (1978)</title><addtitle>J Nucl Med</addtitle><description>Dose-effect calculations used in the planning of modern radiotherapy (RT) involving normal lung or cardiac tissue rely on structural imaging techniques, such as CT, as the basis for measuring and predicting dose-response. However, more accurate methods for predicting dose-response may result if information on the locoregional functional status of the irradiated organ(s) is included in the computational model. For RT cases that involve delivering dose to the lung and heart, this may be achieved by the assessment of tomographic scintigraphies of lung perfusion (Q) and ventilation (V) and scintigraphic imaging of myocardial perfusion and function, respectively.</description><subject>Biological and medical sciences</subject><subject>Breast Neoplasms - radiotherapy</subject><subject>Cardiomyopathies - diagnostic imaging</subject><subject>Cardiomyopathies - etiology</subject><subject>Cardiomyopathies - mortality</subject><subject>Cardiomyopathies - prevention & control</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Heart - radiation effects</subject><subject>Hodgkin Disease - radiotherapy</subject><subject>Humans</subject><subject>Lung - radiation effects</subject><subject>Lymphoma - radiotherapy</subject><subject>Medical sciences</subject><subject>Radiation Injuries - diagnostic imaging</subject><subject>Radiation Injuries - etiology</subject><subject>Radiation Injuries - 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However, more accurate methods for predicting dose-response may result if information on the locoregional functional status of the irradiated organ(s) is included in the computational model. For RT cases that involve delivering dose to the lung and heart, this may be achieved by the assessment of tomographic scintigraphies of lung perfusion (Q) and ventilation (V) and scintigraphic imaging of myocardial perfusion and function, respectively.</abstract><cop>Reston, VA</cop><pub>Soc Nuclear Med</pub><pmid>12960203</pmid><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0161-5505 |
| ispartof | The Journal of nuclear medicine (1978), 2003-09, Vol.44 (9), p.1531-1539 |
| issn | 0161-5505 1535-5667 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Biological and medical sciences Breast Neoplasms - radiotherapy Cardiomyopathies - diagnostic imaging Cardiomyopathies - etiology Cardiomyopathies - mortality Cardiomyopathies - prevention & control Dose-Response Relationship, Radiation Heart - radiation effects Hodgkin Disease - radiotherapy Humans Lung - radiation effects Lymphoma - radiotherapy Medical sciences Radiation Injuries - diagnostic imaging Radiation Injuries - etiology Radiation Injuries - mortality Radiation Injuries - prevention & control Radiation Pneumonitis - diagnostic imaging Radiation Pneumonitis - etiology Radiation Pneumonitis - mortality Radiation Pneumonitis - prevention & control Radiation Protection - methods Radiometry - methods Radionuclide Imaging Radiotherapy - adverse effects Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted - methods Risk Assessment - methods |
| title | The Role of Nuclear Medicine in the Prediction and Detection of Radiation-Associated Normal Pulmonary and Cardiac Damage |
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