Adipose tissue gene expression in patients with a loss of function mutation in the leptin receptor

BACKGROUND: In order to maintain body weight regulation, leptin directly or indirectly signals nutritional changes to key organs, but little is known about its target genes in human adipose tissue. Leptin receptor loss of function is a unique way to explore the role of leptin in the regulation of ad...

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Veröffentlicht in:	International Journal of Obesity 2002-12, Vol.26 (12), p.1533-1538
Hauptverfasser:	Clément, K, Vega, N, Laville, M, Pelloux, V, Guy-Grand, B, Basdevant, A, Vidal, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipocytes - physiology Adipose tissue Adult Aged Biological and medical sciences Biopsy Body fat body mass index Body weight CCAAT-Enhancer-Binding Proteins - genetics DNA-Binding Proteins - genetics Fatty acids Feedback Female Gene expression Gene Expression Regulation - genetics gene overexpression genes girls Humans leptin leptin receptors Medical sciences messenger RNA Metabolic diseases Metabolism Middle Aged Mutation Mutation - genetics Nutrition Nutritional status Obesity Obesity, Morbid - genetics patients Receptors, Cell Surface - genetics Receptors, Cytoplasmic and Nuclear - genetics Receptors, Leptin reverse transcriptase polymerase chain reaction RNA, Messenger - genetics Sequence Analysis, RNA Sterol Regulatory Element Binding Protein 1 transcription (genetics) Transcription factors Transcription Factors - genetics women
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