Tumor Pretargeting: Role of Avidin/Streptavidin on Monoclonal Antibody Internalization

Radioimmunodetection of tumor can be improved by introducing a two-step system in which radiolabeled streptavidin is administrated after the injection of a biotinylated monoclonal antibody (MAb) (two-step) or radiolabeled biotin is injected after biotinylated MAb and avidin (three-step). The anti-ca...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 1997-09, Vol.38 (9), p.1378-1381
Hauptverfasser:	Casalini, Patrizia, Luison, Elena, Menard, Sylvie, Colnaghi, Maria I, Paganelli, Giovanni, Canevari, Silvana
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal Avidin - administration & dosage Bacterial Proteins - administration & dosage Biological and medical sciences Biotin Carcinoembryonic Antigen - biosynthesis Carrier Proteins - immunology Colonic Neoplasms - immunology Female Folate Receptors, GPI-Anchored Host-tumor relations. Immunology. Biological markers Humans Indium Radioisotopes Investigative techniques, diagnostic techniques (general aspects) Iodine Radioisotopes Medical sciences Miscellaneous. Technology Neoplasm Metastasis Ovarian Neoplasms - pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Radioimmunodetection Receptors, Cell Surface - immunology Streptavidin Tomography, Emission-Computed, Single-Photon Tumor Cells, Cultured Tumors
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