Inhibitory effects of chondroitin sulfate prepared from salmon nasal cartilage on fat storage in mice fed a high-fat diet
OBJECTIVE: Chondroitin sulfate is an acidic polymer consisting of repeating D-glucuronic acid and D-N-acetylgalactosamine units, and the N-acetylgalactosamine is substituted with the sulfate at either the 4' or 6' position, with approximately one sulfate being present per disaccharide unit...
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| Veröffentlicht in: | International Journal of Obesity 2000-09, Vol.24 (9), p.1131-1138 |
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| container_title | International Journal of Obesity |
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| creator | Han, L.K Sumiyoshi, M Takeda, T Chihara, H Nishikiori, T Tsujita, T Kimura, Y Okuda, H |
| description | OBJECTIVE: Chondroitin sulfate is an acidic polymer consisting of repeating D-glucuronic acid and D-N-acetylgalactosamine units, and the N-acetylgalactosamine is substituted with the sulfate at either the 4' or 6' position, with approximately one sulfate being present per disaccharide unit. The present study assessed the effects of chondroitin sulfate on the activity of pancreatic lipase and lipid uptake into brush border membrane vesicles of the rat small intestine in vitro, and on the degree of fat storage induced in mice by the oral administration of a high-fat diet for 8 weeks. DESIGN AND MEASUREMENTS: Experiments were carried out to clarify whether or not chondroitin sulfate inhibited pancreatic lipase activity in assay systems using triolein emulsified with phosphatidylcholine or gum arabic. In addition, the effects of chondroitin sulfate on lipid absorption by brush border membrane vesicles were examined. Moreover, mice were fed a high-fat diet and treated with chondroitin sulfate for 8 weeks. RESULTS: Chondroitin sulfate dose-dependently inhibited the pancreatic lipase activity in an assay system using triolein emulsified with phosphatidylcholine. In addition, chondroitin sulfate inhibited the palmitic acid uptake into the brush border membrane vesicles of the rat jejunum. Chondroitin sulfate caused the reduction of body weight and parametrial adipose tissue weight, and prevention of fatty liver and hyperlipidemia in mice fed a high-fat diet. CONCLUSION: The reduction of fat storage and the antihyperlipidemic action of chondroitin sulfate might be due to the inhibition of small intestinal absorption of dietary fat through the inhibition of pancreatic lipase activity and fatty acid uptake through brush border membrane. |
| doi_str_mv | 10.1038/sj.ijo.0801378 |
| format | Article |
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The present study assessed the effects of chondroitin sulfate on the activity of pancreatic lipase and lipid uptake into brush border membrane vesicles of the rat small intestine in vitro, and on the degree of fat storage induced in mice by the oral administration of a high-fat diet for 8 weeks. DESIGN AND MEASUREMENTS: Experiments were carried out to clarify whether or not chondroitin sulfate inhibited pancreatic lipase activity in assay systems using triolein emulsified with phosphatidylcholine or gum arabic. In addition, the effects of chondroitin sulfate on lipid absorption by brush border membrane vesicles were examined. Moreover, mice were fed a high-fat diet and treated with chondroitin sulfate for 8 weeks. RESULTS: Chondroitin sulfate dose-dependently inhibited the pancreatic lipase activity in an assay system using triolein emulsified with phosphatidylcholine. In addition, chondroitin sulfate inhibited the palmitic acid uptake into the brush border membrane vesicles of the rat jejunum. Chondroitin sulfate caused the reduction of body weight and parametrial adipose tissue weight, and prevention of fatty liver and hyperlipidemia in mice fed a high-fat diet. CONCLUSION: The reduction of fat storage and the antihyperlipidemic action of chondroitin sulfate might be due to the inhibition of small intestinal absorption of dietary fat through the inhibition of pancreatic lipase activity and fatty acid uptake through brush border membrane.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/sj.ijo.0801378</identifier><identifier>PMID: 11033981</identifier><identifier>CODEN: IJOBDP</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing</publisher><subject>Absorption ; Adipose tissue ; Adipose Tissue - metabolism ; Administration, Oral ; Animals ; Biochemistry ; Biological and medical sciences ; Body weight ; brush border membrane vesicles ; Cartilage ; Cartilage - chemistry ; Chondroitin sulfate ; Chondroitin Sulfates - pharmacology ; Diet ; dietary fat ; Dietary Fats - administration & dosage ; Dose-Response Relationship, Drug ; Fatty acids ; fatty liver ; Female ; General and cellular metabolism. Vitamins ; glucuronic acid ; gum arabic ; high fat diet ; hyperlipidemia ; Hypolipidemic Agents - pharmacology ; intestinal absorption ; Intestinal Absorption - drug effects ; jejunum ; Lipase - antagonists & inhibitors ; Lipid Metabolism ; Lipids ; Liver - drug effects ; Liver - metabolism ; Male ; Medical research ; Medical sciences ; Membranes ; Mice ; Mice, Inbred ICR ; microvilli ; nose ; Obesity ; Obesity - metabolism ; Oral administration ; palmitic acid ; Pancreas - enzymology ; Pharmacology. Drug treatments ; phosphatidylcholines ; Polymers ; Rats ; Rats, Wistar ; Salmon ; Small intestine ; Sulfates ; tissue weight ; triacylglycerol lipase ; triolein</subject><ispartof>International Journal of Obesity, 2000-09, Vol.24 (9), p.1131-1138</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Sep 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-c532fff7a1325784d415308247a8efaf4bb75f3ad8656ac628e4b2c6c8eaa65d3</citedby><cites>FETCH-LOGICAL-c406t-c532fff7a1325784d415308247a8efaf4bb75f3ad8656ac628e4b2c6c8eaa65d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1473377$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11033981$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, L.K</creatorcontrib><creatorcontrib>Sumiyoshi, M</creatorcontrib><creatorcontrib>Takeda, T</creatorcontrib><creatorcontrib>Chihara, H</creatorcontrib><creatorcontrib>Nishikiori, T</creatorcontrib><creatorcontrib>Tsujita, T</creatorcontrib><creatorcontrib>Kimura, Y</creatorcontrib><creatorcontrib>Okuda, H</creatorcontrib><title>Inhibitory effects of chondroitin sulfate prepared from salmon nasal cartilage on fat storage in mice fed a high-fat diet</title><title>International Journal of Obesity</title><addtitle>Int J Obes Relat Metab Disord</addtitle><description>OBJECTIVE: Chondroitin sulfate is an acidic polymer consisting of repeating D-glucuronic acid and D-N-acetylgalactosamine units, and the N-acetylgalactosamine is substituted with the sulfate at either the 4' or 6' position, with approximately one sulfate being present per disaccharide unit. The present study assessed the effects of chondroitin sulfate on the activity of pancreatic lipase and lipid uptake into brush border membrane vesicles of the rat small intestine in vitro, and on the degree of fat storage induced in mice by the oral administration of a high-fat diet for 8 weeks. DESIGN AND MEASUREMENTS: Experiments were carried out to clarify whether or not chondroitin sulfate inhibited pancreatic lipase activity in assay systems using triolein emulsified with phosphatidylcholine or gum arabic. In addition, the effects of chondroitin sulfate on lipid absorption by brush border membrane vesicles were examined. Moreover, mice were fed a high-fat diet and treated with chondroitin sulfate for 8 weeks. RESULTS: Chondroitin sulfate dose-dependently inhibited the pancreatic lipase activity in an assay system using triolein emulsified with phosphatidylcholine. In addition, chondroitin sulfate inhibited the palmitic acid uptake into the brush border membrane vesicles of the rat jejunum. Chondroitin sulfate caused the reduction of body weight and parametrial adipose tissue weight, and prevention of fatty liver and hyperlipidemia in mice fed a high-fat diet. CONCLUSION: The reduction of fat storage and the antihyperlipidemic action of chondroitin sulfate might be due to the inhibition of small intestinal absorption of dietary fat through the inhibition of pancreatic lipase activity and fatty acid uptake through brush border membrane.</description><subject>Absorption</subject><subject>Adipose tissue</subject><subject>Adipose Tissue - metabolism</subject><subject>Administration, Oral</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Body weight</subject><subject>brush border membrane vesicles</subject><subject>Cartilage</subject><subject>Cartilage - chemistry</subject><subject>Chondroitin sulfate</subject><subject>Chondroitin Sulfates - pharmacology</subject><subject>Diet</subject><subject>dietary fat</subject><subject>Dietary Fats - administration & dosage</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fatty acids</subject><subject>fatty liver</subject><subject>Female</subject><subject>General and cellular metabolism. Vitamins</subject><subject>glucuronic acid</subject><subject>gum arabic</subject><subject>high fat diet</subject><subject>hyperlipidemia</subject><subject>Hypolipidemic Agents - pharmacology</subject><subject>intestinal absorption</subject><subject>Intestinal Absorption - drug effects</subject><subject>jejunum</subject><subject>Lipase - antagonists & inhibitors</subject><subject>Lipid Metabolism</subject><subject>Lipids</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Membranes</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>microvilli</subject><subject>nose</subject><subject>Obesity</subject><subject>Obesity - metabolism</subject><subject>Oral administration</subject><subject>palmitic acid</subject><subject>Pancreas - enzymology</subject><subject>Pharmacology. Drug treatments</subject><subject>phosphatidylcholines</subject><subject>Polymers</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Salmon</subject><subject>Small intestine</subject><subject>Sulfates</subject><subject>tissue weight</subject><subject>triacylglycerol lipase</subject><subject>triolein</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpFkUtr3DAUhUVoSSaPbZetKNl6qrfkZQl9BAJdtFmLa1makbGtqeRZzL-PhjFkdfX4zjlwLkKfKNlSws23MmzjkLbEEMq1uUIbKrRqpGj1B7QhnOiGSCVv0G0pAyFESsKu0Q2tWt4aukGn53kfu7ikfMI-BO-WglPAbp_mPqe4xBmX4xhg8fiQ_QGy73HIacIFxinNeIZ6wA7yEkfYeVyfKoxLNTxfq3yKzuNQZYD3cbdvzt999Ms9-hhgLP5hnXfo9eePf0-_m5c_v56fvr80ThC1NE5yFkLQQDmT2oheUMmJYUKD8QGC6DotA4feKKnAKWa86JhTzngAJXt-h75efA85_T_6stghHfNcIy2jLW1NS3SFthfI5VRK9sEecpwgnywl9ly0LYOtRdu16Cr4vLoeu8n37_jabAUeVwCKgzFkmF0s75zQnOtz8JcLFiBZ2OWKvP5lhKq6LC0ZIfwN3YORJA</recordid><startdate>20000901</startdate><enddate>20000901</enddate><creator>Han, L.K</creator><creator>Sumiyoshi, M</creator><creator>Takeda, T</creator><creator>Chihara, H</creator><creator>Nishikiori, T</creator><creator>Tsujita, T</creator><creator>Kimura, Y</creator><creator>Okuda, H</creator><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20000901</creationdate><title>Inhibitory effects of chondroitin sulfate prepared from salmon nasal cartilage on fat storage in mice fed a high-fat diet</title><author>Han, L.K ; Sumiyoshi, M ; Takeda, T ; Chihara, H ; Nishikiori, T ; Tsujita, T ; Kimura, Y ; Okuda, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-c532fff7a1325784d415308247a8efaf4bb75f3ad8656ac628e4b2c6c8eaa65d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Absorption</topic><topic>Adipose tissue</topic><topic>Adipose Tissue - metabolism</topic><topic>Administration, Oral</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Body weight</topic><topic>brush border membrane vesicles</topic><topic>Cartilage</topic><topic>Cartilage - chemistry</topic><topic>Chondroitin sulfate</topic><topic>Chondroitin Sulfates - pharmacology</topic><topic>Diet</topic><topic>dietary fat</topic><topic>Dietary Fats - administration & dosage</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fatty acids</topic><topic>fatty liver</topic><topic>Female</topic><topic>General and cellular metabolism. Vitamins</topic><topic>glucuronic acid</topic><topic>gum arabic</topic><topic>high fat diet</topic><topic>hyperlipidemia</topic><topic>Hypolipidemic Agents - pharmacology</topic><topic>intestinal absorption</topic><topic>Intestinal Absorption - drug effects</topic><topic>jejunum</topic><topic>Lipase - antagonists & inhibitors</topic><topic>Lipid Metabolism</topic><topic>Lipids</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Membranes</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>microvilli</topic><topic>nose</topic><topic>Obesity</topic><topic>Obesity - metabolism</topic><topic>Oral administration</topic><topic>palmitic acid</topic><topic>Pancreas - enzymology</topic><topic>Pharmacology. Drug treatments</topic><topic>phosphatidylcholines</topic><topic>Polymers</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Salmon</topic><topic>Small intestine</topic><topic>Sulfates</topic><topic>tissue weight</topic><topic>triacylglycerol lipase</topic><topic>triolein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, L.K</creatorcontrib><creatorcontrib>Sumiyoshi, M</creatorcontrib><creatorcontrib>Takeda, T</creatorcontrib><creatorcontrib>Chihara, H</creatorcontrib><creatorcontrib>Nishikiori, T</creatorcontrib><creatorcontrib>Tsujita, T</creatorcontrib><creatorcontrib>Kimura, Y</creatorcontrib><creatorcontrib>Okuda, H</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, L.K</au><au>Sumiyoshi, M</au><au>Takeda, T</au><au>Chihara, H</au><au>Nishikiori, T</au><au>Tsujita, T</au><au>Kimura, Y</au><au>Okuda, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibitory effects of chondroitin sulfate prepared from salmon nasal cartilage on fat storage in mice fed a high-fat diet</atitle><jtitle>International Journal of Obesity</jtitle><addtitle>Int J Obes Relat Metab Disord</addtitle><date>2000-09-01</date><risdate>2000</risdate><volume>24</volume><issue>9</issue><spage>1131</spage><epage>1138</epage><pages>1131-1138</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><coden>IJOBDP</coden><abstract>OBJECTIVE: Chondroitin sulfate is an acidic polymer consisting of repeating D-glucuronic acid and D-N-acetylgalactosamine units, and the N-acetylgalactosamine is substituted with the sulfate at either the 4' or 6' position, with approximately one sulfate being present per disaccharide unit. The present study assessed the effects of chondroitin sulfate on the activity of pancreatic lipase and lipid uptake into brush border membrane vesicles of the rat small intestine in vitro, and on the degree of fat storage induced in mice by the oral administration of a high-fat diet for 8 weeks. DESIGN AND MEASUREMENTS: Experiments were carried out to clarify whether or not chondroitin sulfate inhibited pancreatic lipase activity in assay systems using triolein emulsified with phosphatidylcholine or gum arabic. In addition, the effects of chondroitin sulfate on lipid absorption by brush border membrane vesicles were examined. Moreover, mice were fed a high-fat diet and treated with chondroitin sulfate for 8 weeks. RESULTS: Chondroitin sulfate dose-dependently inhibited the pancreatic lipase activity in an assay system using triolein emulsified with phosphatidylcholine. In addition, chondroitin sulfate inhibited the palmitic acid uptake into the brush border membrane vesicles of the rat jejunum. Chondroitin sulfate caused the reduction of body weight and parametrial adipose tissue weight, and prevention of fatty liver and hyperlipidemia in mice fed a high-fat diet. CONCLUSION: The reduction of fat storage and the antihyperlipidemic action of chondroitin sulfate might be due to the inhibition of small intestinal absorption of dietary fat through the inhibition of pancreatic lipase activity and fatty acid uptake through brush border membrane.</abstract><cop>Basingstoke</cop><pub>Nature Publishing</pub><pmid>11033981</pmid><doi>10.1038/sj.ijo.0801378</doi><tpages>8</tpages></addata></record> |
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| subjects | Absorption Adipose tissue Adipose Tissue - metabolism Administration, Oral Animals Biochemistry Biological and medical sciences Body weight brush border membrane vesicles Cartilage Cartilage - chemistry Chondroitin sulfate Chondroitin Sulfates - pharmacology Diet dietary fat Dietary Fats - administration & dosage Dose-Response Relationship, Drug Fatty acids fatty liver Female General and cellular metabolism. Vitamins glucuronic acid gum arabic high fat diet hyperlipidemia Hypolipidemic Agents - pharmacology intestinal absorption Intestinal Absorption - drug effects jejunum Lipase - antagonists & inhibitors Lipid Metabolism Lipids Liver - drug effects Liver - metabolism Male Medical research Medical sciences Membranes Mice Mice, Inbred ICR microvilli nose Obesity Obesity - metabolism Oral administration palmitic acid Pancreas - enzymology Pharmacology. Drug treatments phosphatidylcholines Polymers Rats Rats, Wistar Salmon Small intestine Sulfates tissue weight triacylglycerol lipase triolein |
| title | Inhibitory effects of chondroitin sulfate prepared from salmon nasal cartilage on fat storage in mice fed a high-fat diet |
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