Claudin-7 Inhibitors for Colon Cancer: A Computational Approach

The initiation of colon cancer is due to dysregulation of the protein Claudin-7. [...]we use bioinformatic tools to find natural compounds for colon cancer. To determine the top lead compound, we used, least binding energy and high number of hydrogen bonds formed as selection criteria. [...]studies show that sustenance of tumor suppressor role of Claudin-7 in the colon8. [...]homology modeling was achieved for the Claudin-7 of colon cancer alongside the preferred template using I-TASSER11.