Imaging of CTLA4 Blockade-Induced Cell Replication with ^sup 18^F-FLT PET in Patients with Advanced Melanoma Treated with Tremelimumab

Preclinical models predict that blockade of the coinhibitory molecule cytotoxic T lymphocyte-associated antigen 4 (CTLA4) on lymphocytes results in the release of a cell cycle inhibitory checkpoint, allowing lymphocyte proliferation, tumor targeting, and regression. However, there is a paucity of da...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2010-03, Vol.51 (3), p.340
Hauptverfasser:	Rìbas, Antoni, Benz, Matthias R, Allen-Auerbach, Martin S, Radu, Caius, Chmielowski, Bartosz, Seja, Elizabeth, Williams, John L, Gomez-Navarro, Jesus, McCarthy, Timothy, Czernin, Johannes
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Cancer therapies Cell cycle Immune system Lymphocytes Patients Spleen T cell receptors Tumors
Online-Zugang:	Volltext
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