Impact of American Joint Committee on Cancer Eighth Edition clinical stage and smoking history on oncologic outcomes in human papillomavirus‐associated oropharyngeal squamous cell carcinoma
Background The purpose of this study was to evaluate the AJCC eighth edition clinical staging system for human papillomavirus (HPV)‐associated oropharyngeal squamous cell carcinoma and to further understand how clinical stage and smoking history affect oncologic outcomes. The purpose of this study w...
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| Veröffentlicht in: | Head & neck 2019-04, Vol.41 (4), p.857-864 |
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| creator | Hawkins, Peter G. Mierzwa, Michelle L. Bellile, Emily Jackson, William C. Malloy, Kelly M. Chinn, Steven B. Spector, Matthew E. Shuman, Andrew G. Stucken, Chaz L. McLean, Scott A. Bradford, Carol R. Prince, Mark E. Carey, Thomas E. Worden, Francis P. Swiecicki, Paul L. Taylor, Jeremy M. G. Wolf, Gregory T. Eisbruch, Avraham Casper, Keith A. |
| description | Background
The purpose of this study was to evaluate the AJCC eighth edition clinical staging system for human papillomavirus (HPV)‐associated oropharyngeal squamous cell carcinoma and to further understand how clinical stage and smoking history affect oncologic outcomes. The purpose of this study was to present the understanding of how clinical stage and smoking history affect oncologic outcomes in human papillomavirus (HPV)‐associated oropharyngeal squamous cell carcinoma (SCC) is critical for selecting patients for treatment deintensification.
Methods
Kaplan‐Meier and Cox regression were used to evaluate overall survival (OS), locoregional recurrence‐free survival (LRFS), and distant recurrence‐free survival (DRFS). Concordance statistics (C‐indices) were used to compare discriminating ability.
Results
The OS and DRFS but not LRFS were significantly distributed using the American Joint Committee on Cancer (AJCC) seventh and eighth editions criteria. The C‐indices for OS, LRFS, and DRFS were 0.57, 0.54, and 0.60, respectively, using the AJCC seventh edition, and 0.63, 0.53, and 0.65, respectively, using the AJCC eighth edition. On multivariate analysis, 1 + pack‐year smoking history correlated with OS (hazard ratio [HR] 1.96; 95% confidence interval [CI] 1.2‐3.1; P |
| doi_str_mv | 10.1002/hed.25336 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2191358101</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2191358101</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3886-d1689552f1598aa66dd4d23ca65adf9466107d9db15e8f9e65a49cc43ea6a5033</originalsourceid><addsrcrecordid>eNp1kUFu1DAYhSNERUthwQWQJVYs0tpx7CTLahjaokpsYB39tZ3EJfaf2g5odhyBG3GXngQP0y67svX0vff06xXFO0bPGKXV-WT0WSU4ly-KE0a7pqS8bl7u_zUvOW3q4-J1jHeUUi7r6lVxnLVGtJU8Kf5euwVUIjiQC2eCVeDJF7Q-kQ06Z1MyhqAnG_DKBLK145QmstU22ayq2frsmElMMBoCXpPo8If1I5lsTBh2ey96hTOOVhFck0JnIrGeTKvLVQssdp7RwU8b1vjw-w_EiMpCMppgwGWCsPOj2Vfcr-BwjUSZeSYKgrI--94URwPM0bx9fE-L75-33zZX5c3Xy-vNxU2peNvKUjPZdkJUAxNdCyCl1rWuuAIpQA9dLSWjje70LROmHTqT5bpTquYGJAjK-Wnx4ZC7BLxfTUz9Ha7B58q-Yh3jomWUZerjgVIBYwxm6JdgXb6hZ7TfT9Xnqfr_U2X2_WPieuuy-kQ-bZOB8wPwy85m93xSf7X9dIj8B-BPox0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2191358101</pqid></control><display><type>article</type><title>Impact of American Joint Committee on Cancer Eighth Edition clinical stage and smoking history on oncologic outcomes in human papillomavirus‐associated oropharyngeal squamous cell carcinoma</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Hawkins, Peter G. ; Mierzwa, Michelle L. ; Bellile, Emily ; Jackson, William C. ; Malloy, Kelly M. ; Chinn, Steven B. ; Spector, Matthew E. ; Shuman, Andrew G. ; Stucken, Chaz L. ; McLean, Scott A. ; Bradford, Carol R. ; Prince, Mark E. ; Carey, Thomas E. ; Worden, Francis P. ; Swiecicki, Paul L. ; Taylor, Jeremy M. G. ; Wolf, Gregory T. ; Eisbruch, Avraham ; Casper, Keith A.</creator><creatorcontrib>Hawkins, Peter G. ; Mierzwa, Michelle L. ; Bellile, Emily ; Jackson, William C. ; Malloy, Kelly M. ; Chinn, Steven B. ; Spector, Matthew E. ; Shuman, Andrew G. ; Stucken, Chaz L. ; McLean, Scott A. ; Bradford, Carol R. ; Prince, Mark E. ; Carey, Thomas E. ; Worden, Francis P. ; Swiecicki, Paul L. ; Taylor, Jeremy M. G. ; Wolf, Gregory T. ; Eisbruch, Avraham ; Casper, Keith A.</creatorcontrib><description>Background
The purpose of this study was to evaluate the AJCC eighth edition clinical staging system for human papillomavirus (HPV)‐associated oropharyngeal squamous cell carcinoma and to further understand how clinical stage and smoking history affect oncologic outcomes. The purpose of this study was to present the understanding of how clinical stage and smoking history affect oncologic outcomes in human papillomavirus (HPV)‐associated oropharyngeal squamous cell carcinoma (SCC) is critical for selecting patients for treatment deintensification.
Methods
Kaplan‐Meier and Cox regression were used to evaluate overall survival (OS), locoregional recurrence‐free survival (LRFS), and distant recurrence‐free survival (DRFS). Concordance statistics (C‐indices) were used to compare discriminating ability.
Results
The OS and DRFS but not LRFS were significantly distributed using the American Joint Committee on Cancer (AJCC) seventh and eighth editions criteria. The C‐indices for OS, LRFS, and DRFS were 0.57, 0.54, and 0.60, respectively, using the AJCC seventh edition, and 0.63, 0.53, and 0.65, respectively, using the AJCC eighth edition. On multivariate analysis, 1 + pack‐year smoking history correlated with OS (hazard ratio [HR] 1.96; 95% confidence interval [CI] 1.2‐3.1; P < .01) but not LRFS or DRFS.
Conclusion
These results support implementation of the AJCC eighth edition for HPV‐associated oropharyngeal SCC. Clinical stage may be more important than smoking history in selection for deintensification.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.25336</identifier><identifier>PMID: 30775826</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>American Joint Committee on Cancer ; clinical staging ; Fish ; Head & neck cancer ; Head and neck ; Human papillomavirus ; human papillomavirus (HPV) ; Multivariate analysis ; oropharyngeal squamous cell carcinoma ; Smoking ; Squamous cell carcinoma ; Statistical analysis ; Throat cancer</subject><ispartof>Head & neck, 2019-04, Vol.41 (4), p.857-864</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3886-d1689552f1598aa66dd4d23ca65adf9466107d9db15e8f9e65a49cc43ea6a5033</citedby><cites>FETCH-LOGICAL-c3886-d1689552f1598aa66dd4d23ca65adf9466107d9db15e8f9e65a49cc43ea6a5033</cites><orcidid>0000-0003-1100-9388 ; 0000-0001-7646-6075</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.25336$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.25336$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30775826$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hawkins, Peter G.</creatorcontrib><creatorcontrib>Mierzwa, Michelle L.</creatorcontrib><creatorcontrib>Bellile, Emily</creatorcontrib><creatorcontrib>Jackson, William C.</creatorcontrib><creatorcontrib>Malloy, Kelly M.</creatorcontrib><creatorcontrib>Chinn, Steven B.</creatorcontrib><creatorcontrib>Spector, Matthew E.</creatorcontrib><creatorcontrib>Shuman, Andrew G.</creatorcontrib><creatorcontrib>Stucken, Chaz L.</creatorcontrib><creatorcontrib>McLean, Scott A.</creatorcontrib><creatorcontrib>Bradford, Carol R.</creatorcontrib><creatorcontrib>Prince, Mark E.</creatorcontrib><creatorcontrib>Carey, Thomas E.</creatorcontrib><creatorcontrib>Worden, Francis P.</creatorcontrib><creatorcontrib>Swiecicki, Paul L.</creatorcontrib><creatorcontrib>Taylor, Jeremy M. G.</creatorcontrib><creatorcontrib>Wolf, Gregory T.</creatorcontrib><creatorcontrib>Eisbruch, Avraham</creatorcontrib><creatorcontrib>Casper, Keith A.</creatorcontrib><title>Impact of American Joint Committee on Cancer Eighth Edition clinical stage and smoking history on oncologic outcomes in human papillomavirus‐associated oropharyngeal squamous cell carcinoma</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
The purpose of this study was to evaluate the AJCC eighth edition clinical staging system for human papillomavirus (HPV)‐associated oropharyngeal squamous cell carcinoma and to further understand how clinical stage and smoking history affect oncologic outcomes. The purpose of this study was to present the understanding of how clinical stage and smoking history affect oncologic outcomes in human papillomavirus (HPV)‐associated oropharyngeal squamous cell carcinoma (SCC) is critical for selecting patients for treatment deintensification.
Methods
Kaplan‐Meier and Cox regression were used to evaluate overall survival (OS), locoregional recurrence‐free survival (LRFS), and distant recurrence‐free survival (DRFS). Concordance statistics (C‐indices) were used to compare discriminating ability.
Results
The OS and DRFS but not LRFS were significantly distributed using the American Joint Committee on Cancer (AJCC) seventh and eighth editions criteria. The C‐indices for OS, LRFS, and DRFS were 0.57, 0.54, and 0.60, respectively, using the AJCC seventh edition, and 0.63, 0.53, and 0.65, respectively, using the AJCC eighth edition. On multivariate analysis, 1 + pack‐year smoking history correlated with OS (hazard ratio [HR] 1.96; 95% confidence interval [CI] 1.2‐3.1; P < .01) but not LRFS or DRFS.
Conclusion
These results support implementation of the AJCC eighth edition for HPV‐associated oropharyngeal SCC. Clinical stage may be more important than smoking history in selection for deintensification.</description><subject>American Joint Committee on Cancer</subject><subject>clinical staging</subject><subject>Fish</subject><subject>Head & neck cancer</subject><subject>Head and neck</subject><subject>Human papillomavirus</subject><subject>human papillomavirus (HPV)</subject><subject>Multivariate analysis</subject><subject>oropharyngeal squamous cell carcinoma</subject><subject>Smoking</subject><subject>Squamous cell carcinoma</subject><subject>Statistical analysis</subject><subject>Throat cancer</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kUFu1DAYhSNERUthwQWQJVYs0tpx7CTLahjaokpsYB39tZ3EJfaf2g5odhyBG3GXngQP0y67svX0vff06xXFO0bPGKXV-WT0WSU4ly-KE0a7pqS8bl7u_zUvOW3q4-J1jHeUUi7r6lVxnLVGtJU8Kf5euwVUIjiQC2eCVeDJF7Q-kQ06Z1MyhqAnG_DKBLK145QmstU22ayq2frsmElMMBoCXpPo8If1I5lsTBh2ey96hTOOVhFck0JnIrGeTKvLVQssdp7RwU8b1vjw-w_EiMpCMppgwGWCsPOj2Vfcr-BwjUSZeSYKgrI--94URwPM0bx9fE-L75-33zZX5c3Xy-vNxU2peNvKUjPZdkJUAxNdCyCl1rWuuAIpQA9dLSWjje70LROmHTqT5bpTquYGJAjK-Wnx4ZC7BLxfTUz9Ha7B58q-Yh3jomWUZerjgVIBYwxm6JdgXb6hZ7TfT9Xnqfr_U2X2_WPieuuy-kQ-bZOB8wPwy85m93xSf7X9dIj8B-BPox0</recordid><startdate>201904</startdate><enddate>201904</enddate><creator>Hawkins, Peter G.</creator><creator>Mierzwa, Michelle L.</creator><creator>Bellile, Emily</creator><creator>Jackson, William C.</creator><creator>Malloy, Kelly M.</creator><creator>Chinn, Steven B.</creator><creator>Spector, Matthew E.</creator><creator>Shuman, Andrew G.</creator><creator>Stucken, Chaz L.</creator><creator>McLean, Scott A.</creator><creator>Bradford, Carol R.</creator><creator>Prince, Mark E.</creator><creator>Carey, Thomas E.</creator><creator>Worden, Francis P.</creator><creator>Swiecicki, Paul L.</creator><creator>Taylor, Jeremy M. G.</creator><creator>Wolf, Gregory T.</creator><creator>Eisbruch, Avraham</creator><creator>Casper, Keith A.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0003-1100-9388</orcidid><orcidid>https://orcid.org/0000-0001-7646-6075</orcidid></search><sort><creationdate>201904</creationdate><title>Impact of American Joint Committee on Cancer Eighth Edition clinical stage and smoking history on oncologic outcomes in human papillomavirus‐associated oropharyngeal squamous cell carcinoma</title><author>Hawkins, Peter G. ; Mierzwa, Michelle L. ; Bellile, Emily ; Jackson, William C. ; Malloy, Kelly M. ; Chinn, Steven B. ; Spector, Matthew E. ; Shuman, Andrew G. ; Stucken, Chaz L. ; McLean, Scott A. ; Bradford, Carol R. ; Prince, Mark E. ; Carey, Thomas E. ; Worden, Francis P. ; Swiecicki, Paul L. ; Taylor, Jeremy M. G. ; Wolf, Gregory T. ; Eisbruch, Avraham ; Casper, Keith A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3886-d1689552f1598aa66dd4d23ca65adf9466107d9db15e8f9e65a49cc43ea6a5033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>American Joint Committee on Cancer</topic><topic>clinical staging</topic><topic>Fish</topic><topic>Head & neck cancer</topic><topic>Head and neck</topic><topic>Human papillomavirus</topic><topic>human papillomavirus (HPV)</topic><topic>Multivariate analysis</topic><topic>oropharyngeal squamous cell carcinoma</topic><topic>Smoking</topic><topic>Squamous cell carcinoma</topic><topic>Statistical analysis</topic><topic>Throat cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hawkins, Peter G.</creatorcontrib><creatorcontrib>Mierzwa, Michelle L.</creatorcontrib><creatorcontrib>Bellile, Emily</creatorcontrib><creatorcontrib>Jackson, William C.</creatorcontrib><creatorcontrib>Malloy, Kelly M.</creatorcontrib><creatorcontrib>Chinn, Steven B.</creatorcontrib><creatorcontrib>Spector, Matthew E.</creatorcontrib><creatorcontrib>Shuman, Andrew G.</creatorcontrib><creatorcontrib>Stucken, Chaz L.</creatorcontrib><creatorcontrib>McLean, Scott A.</creatorcontrib><creatorcontrib>Bradford, Carol R.</creatorcontrib><creatorcontrib>Prince, Mark E.</creatorcontrib><creatorcontrib>Carey, Thomas E.</creatorcontrib><creatorcontrib>Worden, Francis P.</creatorcontrib><creatorcontrib>Swiecicki, Paul L.</creatorcontrib><creatorcontrib>Taylor, Jeremy M. G.</creatorcontrib><creatorcontrib>Wolf, Gregory T.</creatorcontrib><creatorcontrib>Eisbruch, Avraham</creatorcontrib><creatorcontrib>Casper, Keith A.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hawkins, Peter G.</au><au>Mierzwa, Michelle L.</au><au>Bellile, Emily</au><au>Jackson, William C.</au><au>Malloy, Kelly M.</au><au>Chinn, Steven B.</au><au>Spector, Matthew E.</au><au>Shuman, Andrew G.</au><au>Stucken, Chaz L.</au><au>McLean, Scott A.</au><au>Bradford, Carol R.</au><au>Prince, Mark E.</au><au>Carey, Thomas E.</au><au>Worden, Francis P.</au><au>Swiecicki, Paul L.</au><au>Taylor, Jeremy M. G.</au><au>Wolf, Gregory T.</au><au>Eisbruch, Avraham</au><au>Casper, Keith A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of American Joint Committee on Cancer Eighth Edition clinical stage and smoking history on oncologic outcomes in human papillomavirus‐associated oropharyngeal squamous cell carcinoma</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2019-04</date><risdate>2019</risdate><volume>41</volume><issue>4</issue><spage>857</spage><epage>864</epage><pages>857-864</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
The purpose of this study was to evaluate the AJCC eighth edition clinical staging system for human papillomavirus (HPV)‐associated oropharyngeal squamous cell carcinoma and to further understand how clinical stage and smoking history affect oncologic outcomes. The purpose of this study was to present the understanding of how clinical stage and smoking history affect oncologic outcomes in human papillomavirus (HPV)‐associated oropharyngeal squamous cell carcinoma (SCC) is critical for selecting patients for treatment deintensification.
Methods
Kaplan‐Meier and Cox regression were used to evaluate overall survival (OS), locoregional recurrence‐free survival (LRFS), and distant recurrence‐free survival (DRFS). Concordance statistics (C‐indices) were used to compare discriminating ability.
Results
The OS and DRFS but not LRFS were significantly distributed using the American Joint Committee on Cancer (AJCC) seventh and eighth editions criteria. The C‐indices for OS, LRFS, and DRFS were 0.57, 0.54, and 0.60, respectively, using the AJCC seventh edition, and 0.63, 0.53, and 0.65, respectively, using the AJCC eighth edition. On multivariate analysis, 1 + pack‐year smoking history correlated with OS (hazard ratio [HR] 1.96; 95% confidence interval [CI] 1.2‐3.1; P < .01) but not LRFS or DRFS.
Conclusion
These results support implementation of the AJCC eighth edition for HPV‐associated oropharyngeal SCC. Clinical stage may be more important than smoking history in selection for deintensification.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>30775826</pmid><doi>10.1002/hed.25336</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-1100-9388</orcidid><orcidid>https://orcid.org/0000-0001-7646-6075</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | American Joint Committee on Cancer clinical staging Fish Head & neck cancer Head and neck Human papillomavirus human papillomavirus (HPV) Multivariate analysis oropharyngeal squamous cell carcinoma Smoking Squamous cell carcinoma Statistical analysis Throat cancer |
| title | Impact of American Joint Committee on Cancer Eighth Edition clinical stage and smoking history on oncologic outcomes in human papillomavirus‐associated oropharyngeal squamous cell carcinoma |
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