Prescription Opioid Fatalities: Examining Why the Healer Could be the Culprit

Prescription opioid use has increased rapidly in developed countries, as have fatalities and other related adverse events. This review examines the intrinsic characteristics of opioids, including their mechanisms of action and pharmacokinetic and pharmacodynamic properties, to determine how the use...

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Veröffentlicht in:	Drug safety 2018-11, Vol.41 (11), p.1023-1033
Hauptverfasser:	Adewumi, Adeleke D., Staatz, Christine E., Hollingworth, Samantha A., Connor, Jason P., Alati, Rosa
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia Analgesics, Opioid - pharmacokinetics Analgesics, Opioid - pharmacology Analgesics, Opioid - therapeutic use Biological activity Cytochrome P450 Family 2 - metabolism Cytochrome P450 Family 3 - metabolism Dependence Developed countries Drug Administration Schedule Drug dependence Drug overdose Drug Safety and Pharmacovigilance Drug tolerance Drug Tolerance - physiology Endorphins - metabolism Fatalities Humans Hyperalgesia Hyperalgesia - chemically induced Medicine Medicine & Public Health Metabolites Mortality Narcotics Nociception - drug effects Opioids Pain Pain - drug therapy Pain perception Patient Education as Topic Patients Pharmacodynamics Pharmacology Pharmacology/Toxicology Receptors, G-Protein-Coupled - metabolism Receptors, Opioid - metabolism Respiration Respiration - drug effects Respiratory failure Review Article Systematic review Time Factors
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