Dynamic effect of beta-amyloid 42 on cell mechanics

Aβ1-42, which is highly toxic to neural cells, is commonly present in the brains of people with Alzheimer’s disease. In this study, dynamic changes in cell mechanics were monitored under Aβ-induced toxicity. To investigate the changes in cellular mechanical properties, we used Aβ1-42 oligomer at dif...

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Veröffentlicht in:	Journal of biomechanics 2019-03, Vol.86, p.79-88
Hauptverfasser:	Gao, Qi, Fang, Yuqiang, Zhang, Shiqing, Wong, Ho Sze Hersey, Chan, Yee Edward, Wong, Samantha Sze Man, Yung, Ken K.L., Lai, King W.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin AFM Alzheimer's disease Amyloid beta-Peptides - pharmacology Atomic force microscopes Atomic force microscopy Aβ1-42 oligomer Cell Line, Tumor Cell mechanics Cell Membrane - drug effects Cell Membrane - ultrastructure Cell membranes Cytoplasm Cytotoxicity Dismantling Elastic Modulus - drug effects Humans Mechanical properties Mechanics Mechanics (physics) Microtubules - drug effects Modulus of elasticity Neurodegeneration Neurons - drug effects Neurons - ultrastructure Neurotoxicity Osmosis Osmotic pressure Pathogenesis Peptide Fragments - pharmacology Polymerization Silicon nitride Surface tension Toxicity β-Amyloid
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