Evaluation of GABAergic neuroactive steroid 3[alpha]-hydroxy-5[alpha]-pregnane-20-one as a neurobiological substrate for the anti-anxiety effect of ethanol in rats

Acute systemic ethanol administration is known to elevate plasma and cerebral levels of neuroactive steroid 3alpha-hydroxy-5alpha-pregnane-20-one (3alpha, 5alpha-THP; allopregnanolone) to a concentration sufficient to potentiate GABA(A) receptors. We have earlier demonstrated that 3alpha, 5alpha-THP...

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Veröffentlicht in:	Psychopharmacology 2005-07, Vol.180 (2), p.267
Hauptverfasser:	Hirani, Khemraj, Sharma, Ajay N, Jain, Nishant S, Ugale, Rajesh R, Chopde, Chandrabhan T
Format:	Artikel
Sprache:	eng
Schlagworte:	Anxiety
Online-Zugang:	Volltext
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