COVA4231, a potent CD3/CD33 bispecific FynomAb with IgG-like pharmacokinetics for the treatment of acute myeloid leukemia
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Veröffentlicht in: | Leukemia 2019-03, Vol.33 (3), p.805-808 |
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creator | Klupsch, Kristina Baeriswyl, Vanessa Scholz, Roland Dannenberg, Joana Santimaria, Roger Senn, David Kage, Elena Zumsteg, Adrian Attinger-Toller, Isabella von der Bey, Ulrike König-Friedrich, Susann Dupuy, Fanny Lembke, Wibke Albani, Clara Wendelspiess, Severin Dinkel, Lucijana Saro, Dorina Hepler, Robert W. Laszlo, George S. Gudgeon, Chelsea J. Bertschinger, Julian Brack, Simon Walter, Roland B. |
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doi_str_mv | 10.1038/s41375-018-0249-z |
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Ulrike ; König-Friedrich, Susann ; Dupuy, Fanny ; Lembke, Wibke ; Albani, Clara ; Wendelspiess, Severin ; Dinkel, Lucijana ; Saro, Dorina ; Hepler, Robert W. ; Laszlo, George S. ; Gudgeon, Chelsea J. ; Bertschinger, Julian ; Brack, Simon ; Walter, Roland B.</creatorcontrib><identifier>ISSN: 0887-6924</identifier><identifier>EISSN: 1476-5551</identifier><identifier>DOI: 10.1038/s41375-018-0249-z</identifier><identifier>PMID: 30206306</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13 ; 13/1 ; 13/2 ; 631/67/1059/2325 ; 631/67/1990/283/1897 ; 82 ; Acute myelocytic leukemia ; Acute myeloid leukemia ; Analysis ; Animals ; Antibodies, Bispecific - pharmacokinetics ; Antibodies, Bispecific - pharmacology ; Binding proteins ; Brief Communication ; Cancer Research ; Cancer treatment ; CD3 antigen ; CD3 Complex - metabolism ; Cell Line, Tumor ; CHO Cells ; Cricetulus ; Critical Care Medicine ; Dosage and administration ; Drug therapy ; Female 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Julian</creatorcontrib><creatorcontrib>Brack, Simon</creatorcontrib><creatorcontrib>Walter, Roland B.</creatorcontrib><title>COVA4231, a potent CD3/CD33 bispecific FynomAb with IgG-like pharmacokinetics for the treatment of acute myeloid leukemia</title><title>Leukemia</title><addtitle>Leukemia</addtitle><addtitle>Leukemia</addtitle><subject>13</subject><subject>13/1</subject><subject>13/2</subject><subject>631/67/1059/2325</subject><subject>631/67/1990/283/1897</subject><subject>82</subject><subject>Acute myelocytic leukemia</subject><subject>Acute myeloid leukemia</subject><subject>Analysis</subject><subject>Animals</subject><subject>Antibodies, Bispecific - pharmacokinetics</subject><subject>Antibodies, Bispecific - pharmacology</subject><subject>Binding proteins</subject><subject>Brief Communication</subject><subject>Cancer Research</subject><subject>Cancer treatment</subject><subject>CD3 antigen</subject><subject>CD3 Complex - metabolism</subject><subject>Cell Line, Tumor</subject><subject>CHO Cells</subject><subject>Cricetulus</subject><subject>Critical Care Medicine</subject><subject>Dosage and administration</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Gemtuzumab ozogamicin</subject><subject>Hematology</subject><subject>HL-60 Cells</subject><subject>Humans</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin G - metabolism</subject><subject>Intensive</subject><subject>Internal Medicine</subject><subject>Leukemia</subject><subject>Leukemia, Myeloid, Acute - drug therapy</subject><subject>Leukemia, Myeloid, Acute - metabolism</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred NOD</subject><subject>Mice, SCID</subject><subject>Myeloid leukemia</subject><subject>Oncology</subject><subject>Pharmacokinetics</subject><subject>Pharmacology</subject><subject>Sialic Acid Binding Ig-like Lectin 3 - 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a potent CD3/CD33 bispecific FynomAb with IgG-like pharmacokinetics for the treatment of acute myeloid leukemia</title><author>Klupsch, Kristina ; Baeriswyl, Vanessa ; Scholz, Roland ; Dannenberg, Joana ; Santimaria, Roger ; Senn, David ; Kage, Elena ; Zumsteg, Adrian ; Attinger-Toller, Isabella ; von der Bey, Ulrike ; König-Friedrich, Susann ; Dupuy, Fanny ; Lembke, Wibke ; Albani, Clara ; Wendelspiess, Severin ; Dinkel, Lucijana ; Saro, Dorina ; Hepler, Robert W. ; Laszlo, George S. ; Gudgeon, Chelsea J. ; Bertschinger, Julian ; Brack, Simon ; Walter, Roland B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-3a9708ffc77f0383621a273e5662f9dd9cccfaaf1a7824d947f10aec2ab53d793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>13</topic><topic>13/1</topic><topic>13/2</topic><topic>631/67/1059/2325</topic><topic>631/67/1990/283/1897</topic><topic>82</topic><topic>Acute 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metabolism</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred NOD</topic><topic>Mice, SCID</topic><topic>Myeloid leukemia</topic><topic>Oncology</topic><topic>Pharmacokinetics</topic><topic>Pharmacology</topic><topic>Sialic Acid Binding Ig-like Lectin 3 - metabolism</topic><topic>Treatment outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klupsch, Kristina</creatorcontrib><creatorcontrib>Baeriswyl, Vanessa</creatorcontrib><creatorcontrib>Scholz, Roland</creatorcontrib><creatorcontrib>Dannenberg, Joana</creatorcontrib><creatorcontrib>Santimaria, Roger</creatorcontrib><creatorcontrib>Senn, David</creatorcontrib><creatorcontrib>Kage, Elena</creatorcontrib><creatorcontrib>Zumsteg, Adrian</creatorcontrib><creatorcontrib>Attinger-Toller, Isabella</creatorcontrib><creatorcontrib>von der Bey, Ulrike</creatorcontrib><creatorcontrib>König-Friedrich, 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subjects | 13 13/1 13/2 631/67/1059/2325 631/67/1990/283/1897 82 Acute myelocytic leukemia Acute myeloid leukemia Analysis Animals Antibodies, Bispecific - pharmacokinetics Antibodies, Bispecific - pharmacology Binding proteins Brief Communication Cancer Research Cancer treatment CD3 antigen CD3 Complex - metabolism Cell Line, Tumor CHO Cells Cricetulus Critical Care Medicine Dosage and administration Drug therapy Female Gemtuzumab ozogamicin Hematology HL-60 Cells Humans Immunoglobulin G Immunoglobulin G - metabolism Intensive Internal Medicine Leukemia Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - metabolism Medicine Medicine & Public Health Mice Mice, Inbred C57BL Mice, Inbred NOD Mice, SCID Myeloid leukemia Oncology Pharmacokinetics Pharmacology Sialic Acid Binding Ig-like Lectin 3 - metabolism Treatment outcome |
title | COVA4231, a potent CD3/CD33 bispecific FynomAb with IgG-like pharmacokinetics for the treatment of acute myeloid leukemia |
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