COVA4231, a potent CD3/CD33 bispecific FynomAb with IgG-like pharmacokinetics for the treatment of acute myeloid leukemia

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Veröffentlicht in:Leukemia 2019-03, Vol.33 (3), p.805-808
Hauptverfasser: Klupsch, Kristina, Baeriswyl, Vanessa, Scholz, Roland, Dannenberg, Joana, Santimaria, Roger, Senn, David, Kage, Elena, Zumsteg, Adrian, Attinger-Toller, Isabella, von der Bey, Ulrike, König-Friedrich, Susann, Dupuy, Fanny, Lembke, Wibke, Albani, Clara, Wendelspiess, Severin, Dinkel, Lucijana, Saro, Dorina, Hepler, Robert W., Laszlo, George S., Gudgeon, Chelsea J., Bertschinger, Julian, Brack, Simon, Walter, Roland B.
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container_end_page 808
container_issue 3
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container_title Leukemia
container_volume 33
creator Klupsch, Kristina
Baeriswyl, Vanessa
Scholz, Roland
Dannenberg, Joana
Santimaria, Roger
Senn, David
Kage, Elena
Zumsteg, Adrian
Attinger-Toller, Isabella
von der Bey, Ulrike
König-Friedrich, Susann
Dupuy, Fanny
Lembke, Wibke
Albani, Clara
Wendelspiess, Severin
Dinkel, Lucijana
Saro, Dorina
Hepler, Robert W.
Laszlo, George S.
Gudgeon, Chelsea J.
Bertschinger, Julian
Brack, Simon
Walter, Roland B.
description
doi_str_mv 10.1038/s41375-018-0249-z
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identifier ISSN: 0887-6924
ispartof Leukemia, 2019-03, Vol.33 (3), p.805-808
issn 0887-6924
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language eng
recordid cdi_proquest_journals_2188583398
source MEDLINE; SpringerLink Journals (MCLS)
subjects 13
13/1
13/2
631/67/1059/2325
631/67/1990/283/1897
82
Acute myelocytic leukemia
Acute myeloid leukemia
Analysis
Animals
Antibodies, Bispecific - pharmacokinetics
Antibodies, Bispecific - pharmacology
Binding proteins
Brief Communication
Cancer Research
Cancer treatment
CD3 antigen
CD3 Complex - metabolism
Cell Line, Tumor
CHO Cells
Cricetulus
Critical Care Medicine
Dosage and administration
Drug therapy
Female
Gemtuzumab ozogamicin
Hematology
HL-60 Cells
Humans
Immunoglobulin G
Immunoglobulin G - metabolism
Intensive
Internal Medicine
Leukemia
Leukemia, Myeloid, Acute - drug therapy
Leukemia, Myeloid, Acute - metabolism
Medicine
Medicine & Public Health
Mice
Mice, Inbred C57BL
Mice, Inbred NOD
Mice, SCID
Myeloid leukemia
Oncology
Pharmacokinetics
Pharmacology
Sialic Acid Binding Ig-like Lectin 3 - metabolism
Treatment outcome
title COVA4231, a potent CD3/CD33 bispecific FynomAb with IgG-like pharmacokinetics for the treatment of acute myeloid leukemia
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