Long‐Term Prevention of Bacterial Infection and Enhanced Osteoinductivity of a Hybrid Coating with Selective Silver Toxicity

Antibacterial and osteogenic design is required for ideal orthopedic implants. The excellent antimicrobial performance of silver nanoparticles (AgNPs) has attracted interest for the treatment of implant‐related infections. However, the dose‐dependent cytotoxicity of silver and its negative impact on...

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Veröffentlicht in:	Advanced healthcare materials 2019-03, Vol.8 (5), p.e1801465-n/a
Hauptverfasser:	Xie, Kai, Zhou, Ziao, Guo, Yu, Wang, Lei, Li, Guoyuan, Zhao, Shuang, Liu, Xiangmei, Li, Jun, Jiang, Wenbo, Wu, Shuilin, Hao, Yongqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - chemistry antibacterial Bacteria - drug effects Bacterial Infections - drug therapy Bacterial Infections - prevention & control Biocompatibility Biofilms Biomedical materials biosafety Bone implants Cell Differentiation - drug effects Cell Line Chelating agents Chelation Chitosan Chitosan - administration & dosage Chitosan - chemistry Coated Materials, Biocompatible - administration & dosage Coated Materials, Biocompatible - chemistry Coating effects Coatings Cytotoxicity Differentiation (biology) Durapatite - administration & dosage Durapatite - chemistry E coli Female Hydroxyapatite In vivo methods and tests Indoles - administration & dosage Indoles - chemistry Infections Metal Nanoparticles - administration & dosage Metal Nanoparticles - chemistry Mice Nanoparticles Orthopaedic implants Orthopedics Osseointegration Osteogenesis - drug effects Polymers - administration & dosage Polymers - chemistry Rats Rats, Sprague-Dawley Silver Silver - administration & dosage Silver - chemistry silver nanoparticles Surgical implants titanium implants Toxicity Transplants & implants
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