Histopathological and biochemical studies on the effect of curcumin and taurine against bisphenol A toxicity in male rats
Bisphenol A (BPA) is a chemical found in environmental xenoestrogen. In the present study, olive oil, curcumin, taurine, BPA, curcumin plus BPA, and taurine plus BPA were exposed to rats for 4 weeks via gavage. Content of malondialdehyde and activities of antioxidant enzymes (GPx, GST, SOD, CAT) and...
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| Veröffentlicht in: | Environmental science and pollution research international 2019-04, Vol.26 (12), p.12302-12310 |
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| creator | Apaydin, Fatma Gökçe Aslanturk, Ayşe Uzunhisarcikli, Meltem Bas, Hatice Kalender, Suna Kalender, Yusuf |
| description | Bisphenol A (BPA) is a chemical found in environmental xenoestrogen. In the present study, olive oil, curcumin, taurine, BPA, curcumin plus BPA, and taurine plus BPA were exposed to rats for 4 weeks via gavage. Content of malondialdehyde and activities of antioxidant enzymes (GPx, GST, SOD, CAT) and also histopathological and cytopathological changes of heart were studied. No significant changes in all studied parameters were seen between control, olive oil, curcumin, and taurine-treated groups. However, there were significant differences in levels of malondialdehyde and activities of antioxidant enzymes in BPA-exposed rats and some histo/cytopathological changes determined. In curcumin plus BPA-exposed and taurine plus BPA-exposed groups, we measured the preventive effects on some parameters but not exactly. As a result, curcumin and taurine significantly minimized BPA-induced cardiotoxicity in rats. |
| doi_str_mv | 10.1007/s11356-019-04578-4 |
| format | Article |
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In the present study, olive oil, curcumin, taurine, BPA, curcumin plus BPA, and taurine plus BPA were exposed to rats for 4 weeks via gavage. Content of malondialdehyde and activities of antioxidant enzymes (GPx, GST, SOD, CAT) and also histopathological and cytopathological changes of heart were studied. No significant changes in all studied parameters were seen between control, olive oil, curcumin, and taurine-treated groups. However, there were significant differences in levels of malondialdehyde and activities of antioxidant enzymes in BPA-exposed rats and some histo/cytopathological changes determined. In curcumin plus BPA-exposed and taurine plus BPA-exposed groups, we measured the preventive effects on some parameters but not exactly. 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In the present study, olive oil, curcumin, taurine, BPA, curcumin plus BPA, and taurine plus BPA were exposed to rats for 4 weeks via gavage. Content of malondialdehyde and activities of antioxidant enzymes (GPx, GST, SOD, CAT) and also histopathological and cytopathological changes of heart were studied. No significant changes in all studied parameters were seen between control, olive oil, curcumin, and taurine-treated groups. However, there were significant differences in levels of malondialdehyde and activities of antioxidant enzymes in BPA-exposed rats and some histo/cytopathological changes determined. In curcumin plus BPA-exposed and taurine plus BPA-exposed groups, we measured the preventive effects on some parameters but not exactly. 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| subjects | Antioxidants Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Bisphenol A Cardiotoxicity Curcumin Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Enzymes Exposure Heart histopathology males Malondialdehyde Oils & fats Olive oil Organic chemistry Parameters Research Article Rodents Taurine Toxicity Waste Water Technology Water Management Water Pollution Control |
| title | Histopathological and biochemical studies on the effect of curcumin and taurine against bisphenol A toxicity in male rats |
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