$A phase I study to determine the maximum tolerated dose of trifluridine/tipiracil and oxaliplatin in patients with refractory metastatic colorectal cancer: LUPIN study$

A phase I study to determine the maximum tolerated dose of trifluridine/tipiracil and oxaliplatin in patients with refractory metastatic colorectal cancer: LUPIN study

Summary Background The effectiveness of reintroducing oxaliplatin for metastatic colorectal cancer (mCRC) refractory to both oxaliplatin and irinotecan was previously reported in a phase II study (RE-OPEN). We conducted a phase I study to determine the maximum tolerated dose of oxaliplatin plus trif...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Investigational new drugs 2020-02, Vol.38 (1), p.111-119
Hauptverfasser:	Suenaga, Mitsukuni, Wakatsuki, Takeru, Mashima, Tetsuo, Ogura, Mariko, Ichimura, Takashi, Shinozaki, Eiji, Nakayama, Izuma, Osumi, Hiroki, Ota, Yumiko, Takahari, Daisuke, Chin, Keisho, Seimiya, Hiroyuki, Yamaguchi, Kensei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Anorexia Antineoplastic Combined Chemotherapy Protocols - therapeutic use Antiviral drugs Cancer Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Dosage Drug Resistance, Neoplasm - drug effects Female Follow-Up Studies Frontotemporal dementia Humans Hypersensitivity Intravenous administration Irinotecan Liver Neoplasms - drug therapy Liver Neoplasms - secondary Male Maximum Tolerated Dose Medical treatment Medicine Medicine & Public Health Metastases Metastasis Middle Aged Nausea Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - pathology Neutropenia Oncology Oxaliplatin Oxaliplatin - administration & dosage Patients Peripheral neuropathy Pharmacology/Toxicology Phase I Studies Prognosis Prospective Studies Pyrrolidines - administration & dosage Salvage Therapy Studies Thrombocytopenia Thymine - administration & dosage Tissue Distribution Toxicity Trifluridine - administration & dosage Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!